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    eif-2Bdelta Translation initiation factor eIF2B subunit delta [ Caenorhabditis elegans ]

    Gene ID: 179331, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eif-2Bdelta
    Official Full Name
    Translation initiation factor eIF2B subunit delta
    Primary source
    WormBase:WBGene00008670
    Locus tag
    CELE_F11A3.2
    See related
    AllianceGenome:WB:WBGene00008670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable translation initiation factor activity. Involved in several processes, including determination of adult lifespan; lipid storage; and response to heat. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 4. Orthologous to human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eif-2Bdelta in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (9513824..9517649)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene CPG4 domain-containing protein Neighboring gene pseudo Neighboring gene Cocaine- and amphetamine-regulated transcript protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibition of a eukaryotic initiation factor (eIF2Bdelta/F11A3.2) during adulthood extends lifespan in Caenorhabditis elegans. Tohyama D, et al. FASEB J, 2008 Dec. PMID 18728216
    2. SKIP and BIR-1/Survivin have potential to integrate proteome status with gene expression. Kostrouch D, et al. J Proteomics, 2014 Oct 14. PMID 25088050
    3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Translation initiation factor eIF2B subunit delta
    NP_001023784.1
    • Confirmed by transcript evidence
    NP_001023785.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9513824..9517649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028613.3 → NP_001023784.1  Translation initiation factor eIF2B subunit delta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023784.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFF9
      Conserved Domains (1) summary
      cl00348
      Location:227 → 521
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]

    2. NM_001028614.6 → NP_001023785.1  Translation initiation factor eIF2B subunit delta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023785.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG28
      Conserved Domains (1) summary
      cl00348
      Location:195 → 489
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version

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