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    rnp-3 RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177182, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rnp-3
    Official Full Name
    RRM domain-containing protein
    Primary source
    WormBase:WBGene00004386
    Locus tag
    CELE_K08D10.3
    See related
    AllianceGenome:WB:WBGene00004386
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable U1 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U1 snRNP. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA (small nuclear ribonucleoprotein polypeptide A) and SNRPB2 (small nuclear ribonucleoprotein polypeptide B2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rnp-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (4174089..4176279)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ShKT domain-containing protein Neighboring gene RRM domain-containing protein Neighboring gene J domain-containing protein Neighboring gene tRNA-intron lyase;tRNA_int_endo domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional redundancy of worm spliceosomal proteins U1A and U2B''. Saldi T, et al. Proc Natl Acad Sci U S A, 2007 Jun 5. PMID 17535930, Free PMC Article
    2. Spatial and temporal translational control of germ cell mRNAs mediated by the eIF4E isoform IFE-1. Friday AJ, et al. J Cell Sci, 2015 Dec 15. PMID 26542024
    3. Role of the C. elegans U2 snRNP protein MOG-2 in sex determination, meiosis, and splice site selection. Zanetti S, et al. Dev Biol, 2011 Jun 15. PMID 21504747
    4. Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons. Antonacci S, et al. G3 (Bethesda), 2015 Feb 10. PMID 25673135, Free PMC Article
    5. PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability. Cordeiro Rodrigues RJ, et al. Genes Dev, 2019 Jul 1. PMID 31147388, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U1 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RRM domain-containing protein
    NP_001294565.1
    • Confirmed by transcript evidence
    NP_500505.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      4174089..4176279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068104.6 → NP_500505.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500505.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21323
      Conserved Domains (3) summary
      COG0724
      Location:6 → 177
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12246
      Location:9 → 86
      RRM1_U1A_like; RNA recognition motif 1 in the U1A/U2B"/SNF protein family
      cd12247
      Location:141 → 212
      RRM2_U1A_like; RNA recognition motif 2 in the U1A/U2B"/SNF protein family

    2. NM_001307636.3 → NP_001294565.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294565.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBX2
      Conserved Domains (3) summary
      COG0724
      Location:1 → 148
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12246
      Location:1 → 57
      RRM1_U1A_like; RNA recognition motif 1 in the U1A/U2B"/SNF protein family
      cd12247
      Location:112 → 183
      RRM2_U1A_like; RNA recognition motif 2 in the U1A/U2B"/SNF protein family
    Nucleotide Protein
    Heading Accession and Version

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