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    spe-9 Sperm transmembrane protein 9 [ Caenorhabditis elegans ]

    Gene ID: 173042, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spe-9
    Official Full Name
    Sperm transmembrane protein 9
    Primary source
    WormBase:WBGene00004963
    Locus tag
    CELE_C17D12.6
    See related
    AllianceGenome:WB:WBGene00004963
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable signaling receptor binding activity. Involved in single fertilization. Located in cell surface; cytoplasm; and pseudopodium. Is expressed in sperm and spermatid. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and limb ischemia. Orthologous to human DLL1 (delta like canonical Notch ligand 1) and DLL4 (delta like canonical Notch ligand 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See spe-9 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    16
    Sequence:
    Chromosome: I; NC_003279.8 (11582743..11586069, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene tRNA-Lys Neighboring gene Protein containing ALS2cr12 (ALS2CR12) signature Neighboring gene ncRNA Neighboring gene tRNA-Lys Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene UBC core domain-containing protein Neighboring gene ncRNA Neighboring gene RRM domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assessing Collagen Deposition During Aging in Mammalian Tissue and in Caenorhabditis elegans. Teuscher AC, et al. Methods Mol Biol, 2019. PMID 30840243, Free PMC Article
    2. A role for sperm in regulation of egg-laying in the nematode C. elegans. McGovern M, et al. BMC Dev Biol, 2007 May 1. PMID 17472754, Free PMC Article
    3. Visualization of the biphasic calcium wave during fertilization in Caenorhabditis elegans using a genetically encoded calcium indicator. Toperzer KM, et al. Biol Open, 2023 Sep 15. PMID 37602653, Free PMC Article
    4. The mechanism of ran import into the nucleus by nuclear transport factor 2. Quimby BB, et al. J Biol Chem, 2000 Sep 15. PMID 10889207
    5. Heating stress patterns in Caenorhabditis elegans longevity and survivorship. Michalski AI, et al. Biogerontology, 2001. PMID 11708615

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The EGF repeats and the transmembrane domain are required for fertilization. In contrast, the cytoplasmic region of SPE-9 is not essential for fertilization.
      Title: Functional domains and temperature-sensitive mutations in SPE-9, an EGF repeat-containing protein required for fertility in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in pseudopodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sperm transmembrane protein 9
    NP_001129750.1
    • Confirmed by transcript evidence
    NP_492955.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      11582743..11586069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060554.5 → NP_492955.1  Sperm transmembrane protein 9 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492955.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3WFX0, O61537, Q8MLX3, Q8MM25, Q8MV49, Q8MV50, Q8MV51, Q8MV52, Q8MV53, Q8MV54, Q9TVY6

    2. NM_001136278.3 → NP_001129750.1  Sperm transmembrane protein 9 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129750.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9TVY6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TVY6.2

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