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    pcyt-1 Putative choline-phosphate cytidylyltransferase;choline-phosphate cytidylyltransferase [ Caenorhabditis elegans ]

    Gene ID: 181021, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pcyt-1
    Official Full Name
    Putative choline-phosphate cytidylyltransferase;choline-phosphate cytidylyltransferase
    Primary source
    WormBase:WBGene00017241
    Locus tag
    CELE_F08C6.2
    See related
    AllianceGenome:WB:WBGene00017241
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables choline-phosphate cytidylyltransferase activity. Involved in phosphatidylcholine biosynthetic process. Is expressed in head and nervous system. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy and spondylometaphyseal dysplasia with cone-rod dystrophy. Orthologous to human PCYT1A (phosphate cytidylyltransferase 1A, choline) and PCYT1B (phosphate cytidylyltransferase 1B, choline). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pcyt-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (7572357..7581055)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Band 7 domain-containing protein;Stomatin-1 Neighboring gene Vacuolar protein sorting-associated protein 52 homolog Neighboring gene Apyrase apy-1 Neighboring gene Zinc finger protein unc-98 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of hydrophobic amino acids required for lipid activation of C. elegans CTP:phosphocholine cytidylyltransferase. Braker JD, et al. Arch Biochem Biophys, 2009 Dec. PMID 19836342, Free PMC Article
    2. Gene inactivation confirms the identity of enzymes involved in nematode phosphorylcholine-N-glycan synthesis. Houston KM, et al. Mol Biochem Parasitol, 2008 Jan. PMID 17920136
    3. Overactive EGF signaling promotes uv1 cell survival via increased phosphatidylcholine levels and suppression of SBP-1. Crook M, et al. MicroPubl Biol, 2020 Jun 29. PMID 32666045, Free PMC Article
    4. Caenorhabditis elegans numb inhibits endocytic recycling by binding TAT-1 aminophospholipid translocase. Nilsson L, et al. Traffic, 2011 Dec. PMID 21917090
    5. Epidermal Growth Factor Receptor Cell Survival Signaling Requires Phosphatidylcholine Biosynthesis. Crook M, et al. G3 (Bethesda), 2016 Nov 8. PMID 27605519, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables choline-phosphate cytidylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables choline-phosphate cytidylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables choline-phosphate cytidylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-choline pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylcholine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Putative choline-phosphate cytidylyltransferase;choline-phosphate cytidylyltransferase
    NP_001033539.1
    • Confirmed by transcript evidence
    NP_001033540.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7572357..7581055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038450.5 → NP_001033539.1  Putative choline-phosphate cytidylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001033539.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49583
      Conserved Domains (1) summary
      cd02174
      Location:79 → 228
      CCT; CTP:phosphocholine cytidylyltransferase

    2. NM_001038451.3 → NP_001033540.1  choline-phosphate cytidylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001033540.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q3HKC4
      Conserved Domains (1) summary
      cd02174
      Location:71 → 220
      CCT; CTP:phosphocholine cytidylyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49583.2

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