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    vha-14 V-type proton ATPase subunit D [ Caenorhabditis elegans ]

    Gene ID: 176338, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vha-14
    Official Full Name
    V-type proton ATPase subunit D
    Primary source
    WormBase:WBGene00010130
    Locus tag
    CELE_F55H2.2
    See related
    AllianceGenome:WB:WBGene00010130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to contribute to P-type proton-exporting transporter activity. Predicted to be involved in regulation of intracellular pH. Predicted to be part of proton-transporting V-type ATPase complex. Orthologous to human ATP6V1D (ATPase H+ transporting V1 subunit D). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vha-14 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (9508100..9509757)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene RNA polymerase-associated protein CTR9 Neighboring gene Extracellular superoxide dismutase [Cu-Zn];Superoxide dismutase [Cu-Zn] Neighboring gene pseudo Neighboring gene Putative transmembrane ascorbate-dependent reductase CYB561 homolog Neighboring gene Uncharacterized protein Neighboring gene FIP (Fungus-Induced Protein) Related

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An RNAi screen for genes that affect nuclear morphology in Caenorhabditis elegans reveals the involvement of unexpected processes. Maheshwari R, et al. G3 (Bethesda), 2021 Oct 19. PMID 34849797, Free PMC Article
    2. Vacuolar (H+)-ATPases in Caenorhabditis elegans: what can we learn about giant H+ pumps from tiny worms? Lee SK, et al. Biochim Biophys Acta, 2010 Oct. PMID 20637717
    3. Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity. Yu Y, et al. Elife, 2024 Jan 19. PMID 38240316, Free PMC Article
    4. An ECM-to-Nucleus Signaling Pathway Activates Lysosomes for C. elegans Larval Development. Miao R, et al. Dev Cell, 2020 Jan 6. PMID 31735670
    5. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to P-type proton-exporting transporter activity IC
    Inferred by Curator
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular pH IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    part_of proton-transporting V-type ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting V-type ATPase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    V-type proton ATPase subunit D
    NP_499094.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9508100..9509757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066693.7 → NP_499094.1  V-type proton ATPase subunit D [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499094.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34462
      Conserved Domains (1) summary
      pfam01813
      Location:19 → 208
      ATP-synt_D; ATP synthase subunit D
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34462.1

    Gene LinkOut

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