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    pph-4.2 Serine/threonine-protein phosphatase 4 catalytic subunit 2 [ Caenorhabditis elegans ]

    Gene ID: 176663, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pph-4.2
    Official Full Name
    Serine/threonine-protein phosphatase 4 catalytic subunit 2
    Primary source
    WormBase:WBGene00004086
    Locus tag
    CELE_Y49E10.3
    See related
    AllianceGenome:WB:WBGene00004086
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to be active in cytoplasm and nucleus. Orthologous to human PPP4C (protein phosphatase 4 catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pph-4.2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (12374173..12377248, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Histone H3.3 type 2 Neighboring gene ncRNA Neighboring gene 26S proteasome regulatory subunit 8 Neighboring gene Glutaredoxin domain-containing protein Neighboring gene pseudo Neighboring gene Thioredoxin domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis in C. elegans. Sumiyoshi E, et al. J Cell Sci, 2002 Apr 1. PMID 11896188
    2. The role of protein phosphatase 4 in regulating microtubule severing in the Caenorhabditis elegans embryo. Han X, et al. Genetics, 2009 Mar. PMID 19087961, Free PMC Article
    3. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Serine/threonine-protein phosphatase 4 catalytic subunit 2
    NP_001022898.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12374173..12377248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027727.6 → NP_001022898.1  Serine/threonine-protein phosphatase 4 catalytic subunit 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022898.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q966Q3, Q9XTT8
      Conserved Domains (2) summary
      PTZ00239
      Location:16 → 321
      PTZ00239; serine/threonine protein phosphatase 2A; Provisional
      cd07415
      Location:16 → 303
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XTT8.1

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