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    gbh-2 Trimethyllysine dioxygenase, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 174358, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gbh-2
    Official Full Name
    Trimethyllysine dioxygenase, mitochondrial
    Primary source
    WormBase:WBGene00001523
    Locus tag
    CELE_M05D6.7
    See related
    AllianceGenome:WB:WBGene00001523
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable iron ion binding activity and trimethyllysine dioxygenase activity. Predicted to be involved in carnitine biosynthetic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human TMLHE (trimethyllysine hydroxylase, epsilon). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gbh-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (8485879..8487571)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene HIG1 domain-containing protein Neighboring gene TAil-Anchored Protein Neighboring gene Receptor-type tyrosine-protein phosphatase kappa;Receptor-type tyrosine-protein phosphatase mu;Tyrosine-protein phosphatase domain-containing protein Neighboring gene ncRNA Neighboring gene DB domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans. Feng D, et al. PLoS One, 2024. PMID 38517909, Free PMC Article
    2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables trimethyllysine dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carnitine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carnitine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Trimethyllysine dioxygenase, mitochondrial
    NP_495793.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8485879..8487571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063392.3 → NP_495793.2  Trimethyllysine dioxygenase, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495793.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21526
      Conserved Domains (3) summary
      cd00250
      Location:129 → 391
      CAS_like; Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases ...
      TIGR02410
      Location:43 → 402
      carnitine_TMLD; trimethyllysine dioxygenase
      cl01414
      Location:22 → 104
      DUF971; Protein of unknown function (DUF971)
    Nucleotide Protein
    Heading Accession and Version

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