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    faah-4 Monoglyceride lipase faah-4 [ Caenorhabditis elegans ]

    Gene ID: 176620, updated on 9-Dec-2024

    Summary

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    Official Symbol
    faah-4
    Official Full Name
    Monoglyceride lipase faah-4
    Primary source
    WormBase:WBGene00013232
    Locus tag
    CELE_Y56A3A.12
    See related
    AllianceGenome:WB:WBGene00013232
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable amidase activity and fatty acid amide hydrolase activity. Predicted to be involved in fatty acid catabolic process. Human ortholog(s) of this gene implicated in obesity and substance-related disorder. Orthologous to human FAAH (fatty acid amide hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See faah-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (11899337..11906909, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene RRM domain-containing protein Neighboring gene tRNA-intron lyase Neighboring gene F-box associated domain-containing protein Neighboring gene F-box domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan. Chen AL, et al. Nat Chem Biol, 2019 May. PMID 30911178, Free PMC Article
    2. Cannabinoids activate the insulin pathway to modulate mobilization of cholesterol in C. elegans. Hernandez-Cravero B, et al. PLoS Genet, 2022 Nov. PMID 36346800, Free PMC Article
    3. Functional characterization of C. elegans Y-box-binding proteins reveals tissue-specific functions and a critical role in the formation of polysomes. Arnold A, et al. Nucleic Acids Res, 2014 Dec 1. PMID 25378320, Free PMC Article
    4. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    5. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables amidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid amide hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid amide hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoacylglycerol lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Monoglyceride lipase faah-4
    NP_001379259.1
    • Confirmed by transcript evidence
    NP_499545.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11899337..11906909 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392214.1 → NP_001379259.1  Monoglyceride lipase faah-4 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl18951
      Location:80 → 565
      Amidase

    2. NM_067144.7 → NP_499545.1  Monoglyceride lipase faah-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499545.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I4C5, Q9U216, Q9U217
      Conserved Domains (1) summary
      cl18951
      Location:112 → 597
      Amidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U217.1

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