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    Cpb2 carboxypeptidase B2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113936, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cpb2provided by RGD
    Official Full Name
    carboxypeptidase B2provided by RGD
    Primary source
    RGD:71035
    See related
    EnsemblRapid:ENSRNOG00000010935 AllianceGenome:RGD:71035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables carboxypeptidase activity. Involved in several processes, including liver regeneration; negative regulation of hepatocyte proliferation; and regulation of blood coagulation. Located in extracellular space. Human ortholog(s) of this gene implicated in chronic kidney disease. Orthologous to human CPB2 (carboxypeptidase B2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 2523.9) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cpb2 in Genome Data Viewer
    Location:
    15q11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (56967128..57015964)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (50557722..50606569)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (57290849..57339762)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 63 Neighboring gene uncharacterized LOC120097039 Neighboring gene establishment of cohesion 1 homolog 2 (S. cerevisiae), pseudogene 2 Neighboring gene lymphocyte cytosolic protein 1 Neighboring gene tRNA methyltransferase 10A, pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene zinc finger CCCH type containing 13 Neighboring gene siah E3 ubiquitin protein ligase family member 3 Neighboring gene uncharacterized LOC120097040

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables carboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucose stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in fibrinolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fibrinolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in liver regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in negative regulation of fibrinolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of hepatocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of plasminogen activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of extracellular matrix constituent secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    carboxypeptidase B2
    Names
    CPR
    CPU
    TAFI
    carboxypeptidase B2 (plasma)
    carboxypeptidase R
    carboxypeptidase U
    thrombin-activable fibrinolysis inhibitor
    NP_446069.1
    XP_038948873.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053617.2NP_446069.1  carboxypeptidase B2 precursor

      See identical proteins and their annotated locations for NP_446069.1

      Status: VALIDATED

      Source sequence(s)
      BC107447, DY312674
      UniProtKB/Swiss-Prot
      Q3B7V3, Q5BKB8, Q9EQV9
      UniProtKB/TrEMBL
      A6HTS6
      Related
      ENSRNOP00000014909.4, ENSRNOT00000014909.9
      Conserved Domains (2) summary
      cd06246
      Location:118419
      M14_CPB2; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B2 subgroup
      pfam02244
      Location:32103
      Propep_M14; Carboxypeptidase activation peptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      56967128..57015964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092945.2XP_038948873.1  carboxypeptidase B2 isoform X1

      Conserved Domains (1) summary
      cd06246
      Location:25326
      M14_CPB2; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B2 subgroup