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    Rbpjl recombination signal binding protein for immunoglobulin kappa J region-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362268, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbpjlprovided by RGD
    Official Full Name
    recombination signal binding protein for immunoglobulin kappa J region-likeprovided by RGD
    Primary source
    RGD:1304786
    See related
    EnsemblRapid:ENSRNOG00000026295 AllianceGenome:RGD:1304786
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rbpsuhl
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Orthologous to human RBPJL (recombination signal binding protein for immunoglobulin kappa J region like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 40.0), Spleen (RPKM 25.9) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rbpjl in Genome Data Viewer
    Location:
    3q42
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (173553389..173565869)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (153134044..153147421)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (160851836..160865125)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101783 Neighboring gene secretory leukocyte peptidase inhibitor Neighboring gene matrilin 4 Neighboring gene syndecan 4 Neighboring gene Sys1 golgi trafficking protein Neighboring gene TP53 target 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Studies on the cell-type specific expression of RBP-L, a RBP-J family member, by replacement insertion of beta-galactosidase. Minoguchi S, et al. J Biochem, 1999 Oct. PMID 10502683
    2. RBP-L, a transcription factor related to RBP-Jkappa. Minoguchi S, et al. Mol Cell Biol, 1997 May. PMID 9111338, Free PMC Article
    3. Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex. Masui T, et al. Genes Dev, 2007 Oct 15. PMID 17938243, Free PMC Article
    4. The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Hale MA, et al. Development, 2014 Aug. PMID 25063451, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    recombining binding protein suppressor of hairless-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108604.1 → NP_001102074.1  recombining binding protein suppressor of hairless-like protein

      See identical proteins and their annotated locations for NP_001102074.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474005
      UniProtKB/TrEMBL
      A6JX81, D4AEG0
      Related
      ENSRNOP00000019127.5, ENSRNOT00000019127.7
      Conserved Domains (3) summary
      cd01176
      Location:379 → 475
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:205 → 357
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:67 → 203
      LAG1-DNAbind; LAG1, DNA binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      173553389..173565869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235598.5 → XP_006235660.1  recombining binding protein suppressor of hairless-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZXV0
      Related
      ENSRNOP00000084735.1, ENSRNOT00000120074.2
      Conserved Domains (3) summary
      cd01176
      Location:333 → 429
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:202 → 311
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:67 → 203
      LAG1-DNAbind; LAG1, DNA binding

    2. XM_063284218.1 → XP_063140288.1  recombining binding protein suppressor of hairless-like protein isoform X2

    3. XM_063284220.1 → XP_063140290.1  recombining binding protein suppressor of hairless-like protein isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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