U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Lrrc8e leucine rich repeat containing 8 VRAC subunit E [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304203, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Lrrc8eprovided by RGD
    Official Full Name
    leucine rich repeat containing 8 VRAC subunit Eprovided by RGD
    Primary source
    RGD:1311979
    See related
    EnsemblRapid:ENSRNOG00000028460 AllianceGenome:RGD:1311979
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311979
    Summary
    Predicted to enable volume-sensitive anion channel activity. Predicted to be involved in several processes, including aspartate transmembrane transport; cell volume homeostasis; and cyclic-GMP-AMP transmembrane import across plasma membrane. Predicted to be located in endoplasmic reticulum membrane and lysosomal membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human LRRC8E (leucine rich repeat containing 8 VRAC subunit E). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 51.3), Adrenal (RPKM 31.1) and 5 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Lrrc8e in Genome Data Viewer
    Location:
    12p12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (7376103..7387250)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (2578240..2589407)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (2557267..2568416, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene ecotropic viral integration site 5-like Neighboring gene proline rich 36 Neighboring gene mitogen activated protein kinase kinase 7 Neighboring gene transforming growth factor beta receptor 3 like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels. Lutter D, et al. J Cell Sci, 2017 Mar 15. PMID 28193731
    2. LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength. Syeda R, et al. Cell, 2016 Jan 28. PMID 26824658, Free PMC Article
    3. Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. Voss FK, et al. Science, 2014 May 9. PMID 24790029
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC124693

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables volume-sensitive anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to volume-sensitive anion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables volume-sensitive anion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to volume-sensitive anion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in aspartate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aspartate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in aspartate transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell volume homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell volume homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to osmotic stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cyclic-GMP-AMP transmembrane import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cyclic-GMP-AMP transmembrane import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cyclic-GMP-AMP transmembrane import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic anion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic anion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic anion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of monoatomic ion channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of monoatomic ion channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of monoatomic ion channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    volume-regulated anion channel subunit LRRC8E
    Names
    leucine rich repeat containing 8 family, member E
    leucine-rich repeat-containing protein 8E

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034139.2 → NP_001029311.1  volume-regulated anion channel subunit LRRC8E

      See identical proteins and their annotated locations for NP_001029311.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q3KRC6
      Conserved Domains (4) summary
      cd00116
      Location:526 → 790
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:559 → 582
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 330
      Pannexin_like; Pannexin-like TM region of LRRC8
      pfam13855
      Location:676 → 733
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      7376103..7387250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248763.5 → XP_006248825.1  volume-regulated anion channel subunit LRRC8E isoform X1

      See identical proteins and their annotated locations for XP_006248825.1

      UniProtKB/Swiss-Prot
      Q3KRC6
      Conserved Domains (4) summary
      cd00116
      Location:526 → 790
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:559 → 582
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 330
      Pannexin_like; Pannexin-like TM region of LRRC8
      pfam13855
      Location:676 → 733
      LRR_8; Leucine rich repeat

    2. XM_006248764.5 → XP_006248826.1  volume-regulated anion channel subunit LRRC8E isoform X1

      See identical proteins and their annotated locations for XP_006248826.1

      UniProtKB/Swiss-Prot
      Q3KRC6
      Conserved Domains (4) summary
      cd00116
      Location:526 → 790
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:559 → 582
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 330
      Pannexin_like; Pannexin-like TM region of LRRC8
      pfam13855
      Location:676 → 733
      LRR_8; Leucine rich repeat

    3. XM_063271246.1 → XP_063127316.1  volume-regulated anion channel subunit LRRC8E isoform X1

      UniProtKB/Swiss-Prot
      Q3KRC6
      Related
      ENSRNOP00000037487.3, ENSRNOT00000035142.6

    4. XM_063271247.1 → XP_063127317.1  volume-regulated anion channel subunit LRRC8E isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3KRC6.1 GenPept UniProtKB/Swiss-Prot:Q3KRC6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous