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    Ctif cap binding complex dependent translation initiation factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364900, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ctifprovided by RGD
    Official Full Name
    cap binding complex dependent translation initiation factorprovided by RGD
    Primary source
    RGD:1311887
    See related
    EnsemblRapid:ENSRNOG00000018342 AllianceGenome:RGD:1311887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gm672
    Summary
    Predicted to enable translation activator activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and regulation of translational initiation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol. Orthologous to human CTIF (cap binding complex dependent translation initiation factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 102.8), Brain (RPKM 52.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ctif in Genome Data Viewer
    Location:
    18q12.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (71331222..71602493, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (69056151..69327454, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (71467381..71701423, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556053 Neighboring gene SMAD family member 7 Neighboring gene uncharacterized LOC120098120 Neighboring gene peroxisomal biogenesis factor 19-like Neighboring gene uncharacterized LOC102548225 Neighboring gene uncharacterized LOC120098205 Neighboring gene uncharacterized LOC134483052 Neighboring gene uncharacterized LOC102556385 Neighboring gene zinc finger and BTB domain containing 7C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation. Kim KM, et al. Genes Dev, 2009 Sep 1. PMID 19648179, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CBP80/20-dependent translation initiation factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108891.2 → NP_001102361.2  CBP80/20-dependent translation initiation factor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      D3ZD47
      Related
      ENSRNOP00000071241.2, ENSRNOT00000088662.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      71331222..71602493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097004.2 → XP_038952932.1  CBP80/20-dependent translation initiation factor isoform X3

      UniProtKB/TrEMBL
      D3ZD47
      Related
      ENSRNOP00000107893.1, ENSRNOT00000155127.1
      Conserved Domains (1) summary
      pfam02854
      Location:379 → 579
      MIF4G; MIF4G domain

    2. XM_063277493.1 → XP_063133563.1  CBP80/20-dependent translation initiation factor isoform X3

      UniProtKB/TrEMBL
      D3ZD47
      Related
      ENSRNOP00000094890.2, ENSRNOT00000098958.2

    3. XM_039097008.2 → XP_038952936.1  CBP80/20-dependent translation initiation factor isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQ79, D3ZD47
      Conserved Domains (1) summary
      pfam02854
      Location:402 → 602
      MIF4G; MIF4G domain

    4. XM_063277494.1 → XP_063133564.1  CBP80/20-dependent translation initiation factor isoform X4

      UniProtKB/TrEMBL
      D3ZD47

    5. XM_039097007.2 → XP_038952935.1  CBP80/20-dependent translation initiation factor isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQ79, D3ZD47
      Related
      ENSRNOP00000024716.8, ENSRNOT00000024716.8
      Conserved Domains (1) summary
      pfam02854
      Location:402 → 602
      MIF4G; MIF4G domain

    6. XM_039097006.2 → XP_038952934.1  CBP80/20-dependent translation initiation factor isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQ79, D3ZD47
      Conserved Domains (1) summary
      pfam02854
      Location:402 → 602
      MIF4G; MIF4G domain

    7. XM_039097010.2 → XP_038952938.1  CBP80/20-dependent translation initiation factor isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQ79, D3ZD47
      Conserved Domains (1) summary
      pfam02854
      Location:402 → 602
      MIF4G; MIF4G domain

    8. XM_039097003.1 → XP_038952931.1  CBP80/20-dependent translation initiation factor isoform X1

      UniProtKB/TrEMBL
      D3ZD47
      Conserved Domains (1) summary
      pfam02854
      Location:400 → 600
      MIF4G; MIF4G domain
    Nucleotide Protein Strain
    Heading Accession and Version

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