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    Gsdmdl1 gasdermin D like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314959, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gsdmdl1provided by RGD
    Official Full Name
    gasdermin D like 1provided by RGD
    Primary source
    RGD:1359449
    See related
    EnsemblRapid:ENSRNOG00000059240 AllianceGenome:RGD:1359449
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1359449
    Summary
    Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Predicted to be involved in defense response to bacterium and pyroptotic inflammatory response. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 136.9), Spleen (RPKM 23.9) and 2 other tissues See more
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    Genomic context

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    See Gsdmdl1 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (97509288..97519788)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (95620052..95630546)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (104500564..104511236)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta, pseudogene 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene gasdermin C Neighboring gene CYFIP related Rac1 interactor B Neighboring gene uncharacterized LOC120093676 Neighboring gene uncharacterized LOC134479920

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyroptotic inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gasdermin D like 1
    Names
    gasdermin domain containing protein RGD1359449

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014084.1 → NP_001014106.1  gasdermin D like 1

      See identical proteins and their annotated locations for NP_001014106.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079239
      UniProtKB/TrEMBL
      Q6AY10
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 238
      Gasdermin; Gasdermin family
      pfam17708
      Location:258 → 380
      Gasdermin_C; Gasdermin PUB domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      97509288..97519788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263521.1 → XP_063119591.1  gasdermin D like 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7V2
      Related
      ENSRNOP00000074359.2, ENSRNOT00000090226.3

    2. XM_006241642.5 → XP_006241704.1  gasdermin D like 1 isoform X2

      See identical proteins and their annotated locations for XP_006241704.1

      UniProtKB/TrEMBL
      Q6AY10
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 238
      Gasdermin; Gasdermin family
      pfam17708
      Location:258 → 380
      Gasdermin_C; Gasdermin PUB domain

    3. XM_039079164.2 → XP_038935092.1  gasdermin D like 1 isoform X2

      UniProtKB/TrEMBL
      Q6AY10
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 238
      Gasdermin; Gasdermin family
      pfam17708
      Location:258 → 380
      Gasdermin_C; Gasdermin PUB domain

    4. XM_063263517.1 → XP_063119587.1  gasdermin D like 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7V2

    5. XM_063263525.1 → XP_063119595.1  gasdermin D like 1 isoform X2

      UniProtKB/TrEMBL
      Q6AY10

    6. XM_063263524.1 → XP_063119594.1  gasdermin D like 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7V2

    7. XM_039079168.2 → XP_038935096.1  gasdermin D like 1 isoform X3

      Conserved Domains (2) summary
      pfam04598
      Location:4 → 238
      Gasdermin; Gasdermin family
      pfam17708
      Location:258 → 380
      Gasdermin_C; Gasdermin PUB domain

    8. XM_063263518.1 → XP_063119588.1  gasdermin D like 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7V2

    9. XM_039079167.1 → XP_038935095.1  gasdermin D like 1 isoform X2

      UniProtKB/TrEMBL
      Q6AY10
      Conserved Domains (2) summary
      pfam04598
      Location:4 → 238
      Gasdermin; Gasdermin family
      pfam17708
      Location:258 → 380
      Gasdermin_C; Gasdermin PUB domain

    10. XM_063263526.1 → XP_063119596.1  gasdermin D like 1 isoform X2

      UniProtKB/TrEMBL
      Q6AY10

    11. XM_063263522.1 → XP_063119592.1  gasdermin D like 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7V2

    12. XM_063263528.1 → XP_063119598.1  gasdermin D like 1 isoform X2

      UniProtKB/TrEMBL
      Q6AY10

    13. XM_063263520.1 → XP_063119590.1  gasdermin D like 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7V2

    14. XM_063263523.1 → XP_063119593.1  gasdermin D like 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7V2

    RNA

    1. XR_010052973.1 RNA Sequence

    2. XR_010052972.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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