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    Btbd3 BTB domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311462, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Btbd3provided by RGD
    Official Full Name
    BTB domain containing 3provided by RGD
    Primary source
    RGD:1311623
    See related
    EnsemblRapid:ENSRNOG00000008088 AllianceGenome:RGD:1311623
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in cerebral cortex development and dendrite morphogenesis. Predicted to be located in nucleus. Predicted to be active in cytosol. Orthologous to human BTBD3 (BTB domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 376.5), Lung (RPKM 217.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Btbd3 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (146044053..146074189)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (125591427..125621660)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (131330338..131360554)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene calcineurin-like EF-hand protein 1, pseudogene 1 Neighboring gene uncharacterized LOC120101698 Neighboring gene uncharacterized LOC120101704 Neighboring gene uncharacterized LOC134486452

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. Matsui A, et al. Science, 2013 Nov 29. PMID 24179155
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cerebral cortex development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein 3
    Names
    BTB (POZ) domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107782.1 → NP_001101252.1  BTB/POZ domain-containing protein 3

      See identical proteins and their annotated locations for NP_001101252.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A6HQL4, D3ZJC0
      Related
      ENSRNOP00000010835.4, ENSRNOT00000010835.7
      Conserved Domains (4) summary
      smart00225
      Location:127 → 226
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:232 → 338
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:119 → 222
      BTB; BTB/POZ domain
      pfam08005
      Location:383 → 526
      PHR; PHR domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      146044053..146074189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235099.5 → XP_006235161.1  BTB/POZ domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIZ4
      Related
      ENSRNOP00000093542.1, ENSRNOT00000114685.2
      Conserved Domains (4) summary
      smart00225
      Location:60 → 159
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:165 → 271
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:52 → 155
      BTB; BTB/POZ domain
      pfam08005
      Location:316 → 459
      PHR; PHR domain
    Nucleotide Protein Strain
    Heading Accession and Version

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