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    Ptpa protein phosphatase 2 phosphatase activator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362102, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ptpaprovided by RGD
    Official Full Name
    protein phosphatase 2 phosphatase activatorprovided by RGD
    Primary source
    RGD:1308354
    See related
    EnsemblRapid:ENSRNOG00000018457 AllianceGenome:RGD:1308354
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ppp2r4
    Summary
    Predicted to enable several functions, including ATP binding activity; protein homodimerization activity; and protein phosphatase 2A binding activity. Predicted to contribute to phosphoprotein phosphatase activity. Predicted to be involved in mitotic spindle organization and positive regulation of apoptotic process. Predicted to be located in nucleoplasm. Predicted to be part of ATPase complex; calcium channel complex; and protein phosphatase type 2A complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease 25. Orthologous to human PTPA (protein phosphatase 2 phosphatase activator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 422.8), Thymus (RPKM 400.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptpa in Genome Data Viewer
    Location:
    3p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (34087637..34118100)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13689742..13720287)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8982122..9012585)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene dolichyldiphosphatase 1 Neighboring gene carnitine O-acetyltransferase Neighboring gene uncharacterized LOC120101516 Neighboring gene immediate early response 5-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure and mechanism of the phosphotyrosyl phosphatase activator. Chao Y, et al. Mol Cell, 2006 Aug. PMID 16916641
    2. Overexpression of the cis/trans isomerase PTPA triggers caspase 3-dependent apoptosis. Azam S, et al. Apoptosis, 2007 Jul. PMID 17333320
    3. Compression alters kinase and phosphatase activity and tau and MAP2 phosphorylation transiently while inducing the fast adaptive dendritic remodeling of underlying cortical neurons. Chen LJ, et al. J Neurotrauma, 2010 Sep. PMID 20568963
    4. A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. Ogris E, et al. J Biol Chem, 1999 May 14. PMID 10318862, Free PMC Article
    5. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Marx SO, et al. Cell, 2000 May 12. PMID 10830164

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein phosphatase 2A, but not 2B, activity is downregulated following compressive injury of the cerebral cortex.
      Title: Compression alters kinase and phosphatase activity and tau and MAP2 phosphorylation transiently while inducing the fast adaptive dendritic remodeling of underlying cortical neurons.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A activator
    Names
    protein phosphatase 2 regulatory subunit 4
    protein phosphatase 2A activator, regulatory subunit 4
    protein phosphatase 2A regulatory subunit 4
    protein phosphatase 2A, regulatory subunit B (PR 53)
    NP_001102047.1
    XP_038961297.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108577.2 → NP_001102047.1  serine/threonine-protein phosphatase 2A activator

      See identical proteins and their annotated locations for NP_001102047.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166861
      UniProtKB/TrEMBL
      B2RYQ2, F7FF51
      Related
      ENSRNOP00000104822.1, ENSRNOT00000128095.1
      Conserved Domains (1) summary
      pfam03095
      Location:26 → 316
      PTPA; Phosphotyrosyl phosphate activator (PTPA) protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      34087637..34118100
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105369.2 → XP_038961297.1  serine/threonine-protein phosphatase 2A activator isoform X1

      Related
      ENSRNOP00000109918.1, ENSRNOT00000135308.1
      Conserved Domains (1) summary
      pfam03095
      Location:26 → 229
      PTPA; Phosphotyrosyl phosphate activator (PTPA) protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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