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    Ccni cyclin I [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289500, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ccniprovided by RGD
    Official Full Name
    cyclin Iprovided by RGD
    Primary source
    RGD:1309209
    See related
    EnsemblRapid:ENSRNOG00000002125 AllianceGenome:RGD:1309209
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in G1/S transition of mitotic cell cycle. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human CCNI (cyclin I). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 661.1), Kidney (RPKM 601.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ccni in Genome Data Viewer
    Location:
    14p22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (15164047..15186885)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (14879698..14902510)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (16341510..16364326)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S3, pseudogene 2 Neighboring gene cyclin G2 Neighboring gene septin 11 Neighboring gene uncharacterized LOC134481828 Neighboring gene uncharacterized LOC134481721 Neighboring gene small nucleolar RNA SNORA70

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105998.1NP_001099468.1  cyclin-I

      See identical proteins and their annotated locations for NP_001099468.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474060
      UniProtKB/TrEMBL
      A6KK51, D4A5E4
      Related
      ENSRNOP00000002924.5, ENSRNOT00000002924.7
      Conserved Domains (1) summary
      cd20526
      Location:44142
      CYCLIN_CCNI-like; cyclin box found in cyclin-I (CCNI) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      15164047..15186885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250715.5XP_006250777.1  cyclin-I isoform X1

      See identical proteins and their annotated locations for XP_006250777.1

      UniProtKB/TrEMBL
      A6KK51, D4A5E4
      Conserved Domains (1) summary
      cd20526
      Location:44142
      CYCLIN_CCNI-like; cyclin box found in cyclin-I (CCNI) and similar proteins
    2. XM_063272900.1XP_063128970.1  cyclin-I isoform X2

      Related
      ENSRNOP00000105637.1, ENSRNOT00000137202.1