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    FAM200B family with sequence similarity 200 member B [ Homo sapiens (human) ]

    Gene ID: 285550, updated on 27-Nov-2024

    Summary

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    Official Symbol
    FAM200Bprovided by HGNC
    Official Full Name
    family with sequence similarity 200 member Bprovided by HGNC
    Primary source
    HGNC:HGNC:27740
    See related
    Ensembl:ENSG00000237765 AllianceGenome:HGNC:27740
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C4orf53
    Expression
    Ubiquitous expression in brain (RPKM 6.0), thyroid (RPKM 5.5) and 25 other tissues See more
    Orthologs
    all
    NEW
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    Genomic context

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    See FAM200B in Genome Data Viewer
    Location:
    4p15.32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (15636791..15690447)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (15618958..15672602)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (15683450..15692070)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene coiled-coil and C2 domain containing 2A Neighboring gene uncharacterized LOC124900672 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:15545311-15545892 Neighboring gene uncharacterized LOC124900671 Neighboring gene F-box and leucine rich repeat protein 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:15637196-15637392 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:15648787-15649012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15297 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:15656873-15657050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21343 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:15696758-15697354 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15300 Neighboring gene bone marrow stromal cell antigen 1 Neighboring gene ribosomal protein L10a pseudogene 7 Neighboring gene PFDN1 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of host proteins required for HIV infection through a functional genomic screen. Brass AL, et al. Science, 2008 Feb 15. PMID 18187620
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, et al. Nature, 2005 Apr 7. PMID 15815621
    3. TNIP2 is a Hub Protein in the NF-ÎşB Network with Both Protein and RNA Mediated Interactions. Banks CA, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609421, Free PMC Article
    4. TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing. Demirdizen E, et al. Neuro Oncol, 2023 Jun 2. PMID 36215168, Free PMC Article
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of family with sequence similarity 200, member B (FAM200B; LOC285550) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    protein FAM200B
    Names
    Putative protein FAM200B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145191.2 → NP_001138663.1  protein FAM200B

      See identical proteins and their annotated locations for NP_001138663.1

      Status: VALIDATED

      Source sequence(s)
      AC114744, BC035074, BQ004196
      Consensus CDS
      CCDS47028.1
      UniProtKB/Swiss-Prot
      P0CF97
      Related
      ENSP00000393017.2, ENST00000422728.3
      Conserved Domains (1) summary
      pfam14291
      Location:184 → 304
      DUF4371; Domain of unknown function (DUF4371)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      15636791..15690447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047450112.1 → XP_047306068.1  protein FAM200B isoform X1

      UniProtKB/Swiss-Prot
      P0CF97

    2. XM_047450110.1 → XP_047306066.1  protein FAM200B isoform X1

      UniProtKB/Swiss-Prot
      P0CF97

    3. XM_047450107.1 → XP_047306063.1  protein FAM200B isoform X1

      UniProtKB/Swiss-Prot
      P0CF97

    4. XM_047450106.1 → XP_047306062.1  protein FAM200B isoform X1

      UniProtKB/Swiss-Prot
      P0CF97

    5. XM_047450117.1 → XP_047306073.1  protein FAM200B isoform X2

    6. XM_024454005.2 → XP_024309773.1  protein FAM200B isoform X1

      UniProtKB/Swiss-Prot
      P0CF97
      Conserved Domains (1) summary
      pfam14291
      Location:184 → 304
      DUF4371; Domain of unknown function (DUF4371)

    7. XM_024454006.2 → XP_024309774.1  protein FAM200B isoform X1

      UniProtKB/Swiss-Prot
      P0CF97
      Conserved Domains (1) summary
      pfam14291
      Location:184 → 304
      DUF4371; Domain of unknown function (DUF4371)

    8. XM_024454011.2 → XP_024309779.1  protein FAM200B isoform X2

    9. XM_047450104.1 → XP_047306060.1  protein FAM200B isoform X1

      UniProtKB/Swiss-Prot
      P0CF97

    10. XM_024454010.2 → XP_024309778.1  protein FAM200B isoform X2

    11. XM_024454001.2 → XP_024309769.1  protein FAM200B isoform X1

      UniProtKB/Swiss-Prot
      P0CF97
      Conserved Domains (1) summary
      pfam14291
      Location:184 → 304
      DUF4371; Domain of unknown function (DUF4371)

    12. XM_024454003.2 → XP_024309771.1  protein FAM200B isoform X1

      UniProtKB/Swiss-Prot
      P0CF97
      Conserved Domains (1) summary
      pfam14291
      Location:184 → 304
      DUF4371; Domain of unknown function (DUF4371)

    13. XM_024454009.2 → XP_024309777.1  protein FAM200B isoform X2

    14. XM_047450103.1 → XP_047306059.1  protein FAM200B isoform X1

      UniProtKB/Swiss-Prot
      P0CF97

    15. XM_047450114.1 → XP_047306070.1  protein FAM200B isoform X2

    16. XM_047450108.1 → XP_047306064.1  protein FAM200B isoform X1

      UniProtKB/Swiss-Prot
      P0CF97

    17. XM_047450109.1 → XP_047306065.1  protein FAM200B isoform X1

      UniProtKB/Swiss-Prot
      P0CF97

    18. XM_047450113.1 → XP_047306069.1  protein FAM200B isoform X2

    19. XM_017008048.2 → XP_016863537.1  protein FAM200B isoform X1

      UniProtKB/Swiss-Prot
      P0CF97
      Conserved Domains (1) summary
      pfam14291
      Location:184 → 304
      DUF4371; Domain of unknown function (DUF4371)

    20. XM_047450115.1 → XP_047306071.1  protein FAM200B isoform X2

    21. XM_024453999.2 → XP_024309767.1  protein FAM200B isoform X1

      UniProtKB/Swiss-Prot
      P0CF97
      Conserved Domains (1) summary
      pfam14291
      Location:184 → 304
      DUF4371; Domain of unknown function (DUF4371)

    22. XM_024454000.2 → XP_024309768.1  protein FAM200B isoform X1

      UniProtKB/Swiss-Prot
      P0CF97
      Conserved Domains (1) summary
      pfam14291
      Location:184 → 304
      DUF4371; Domain of unknown function (DUF4371)

    23. XM_024454008.2 → XP_024309776.1  protein FAM200B isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      15618958..15672602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349774.1 → XP_054205749.1  protein FAM200B isoform X1

    2. XM_054349773.1 → XP_054205748.1  protein FAM200B isoform X1

    3. XM_054349763.1 → XP_054205738.1  protein FAM200B isoform X1

    4. XM_054349780.1 → XP_054205755.1  protein FAM200B isoform X2

    5. XM_054349771.1 → XP_054205746.1  protein FAM200B isoform X1

    6. XM_054349772.1 → XP_054205747.1  protein FAM200B isoform X1

    7. XM_054349779.1 → XP_054205754.1  protein FAM200B isoform X2

    8. XM_054349762.1 → XP_054205737.1  protein FAM200B isoform X1

    9. XM_054349781.1 → XP_054205756.1  protein FAM200B isoform X2

    10. XM_054349769.1 → XP_054205744.1  protein FAM200B isoform X1

    11. XM_054349770.1 → XP_054205745.1  protein FAM200B isoform X1

    12. XM_054349778.1 → XP_054205753.1  protein FAM200B isoform X2

    13. XM_054349766.1 → XP_054205741.1  protein FAM200B isoform X1

    14. XM_054349765.1 → XP_054205740.1  protein FAM200B isoform X1

    15. XM_054349784.1 → XP_054205759.1  protein FAM200B isoform X2

    16. XM_054349775.1 → XP_054205750.1  protein FAM200B isoform X1

    17. XM_054349776.1 → XP_054205751.1  protein FAM200B isoform X1

    18. XM_054349783.1 → XP_054205758.1  protein FAM200B isoform X2

    19. XM_054349764.1 → XP_054205739.1  protein FAM200B isoform X1

    20. XM_054349782.1 → XP_054205757.1  protein FAM200B isoform X2

    21. XM_054349767.1 → XP_054205742.1  protein FAM200B isoform X1

    22. XM_054349768.1 → XP_054205743.1  protein FAM200B isoform X1

    23. XM_054349777.1 → XP_054205752.1  protein FAM200B isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CF97.1 GenPept UniProtKB/Swiss-Prot:P0CF97

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