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    GOLGA8S golgin A8 family member S [ Homo sapiens (human) ]

    Gene ID: 653061, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GOLGA8Sprovided by HGNC
    Official Full Name
    golgin A8 family member Sprovided by HGNC
    Primary source
    HGNC:HGNC:44409
    See related
    Ensembl:ENSG00000261739 AllianceGenome:HGNC:44409
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 16.5), thyroid (RPKM 6.9) and 14 other tissues See more
    Orthologs
    all
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    Genomic context

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    See GOLGA8S in Genome Data Viewer
    Location:
    15q11.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (23354748..23368489)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (21091026..21104791)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (23599895..23613636)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene golgin A6 family like 26 Neighboring gene uncharacterized LOC105376698 Neighboring gene uncharacterized LOC105370726 Neighboring gene RNA, 7SL, cytoplasmic 536, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:23618137-23618636 Neighboring gene uncharacterized LOC124903446 Neighboring gene uncharacterized LOC105370728

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Analysis of the DNA sequence and duplication history of human chromosome 15. Zody MC, et al. Nature, 2006 Mar 30. PMID 16572171
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi cis cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi cisterna membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cis-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    golgin subfamily A member 8S

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355465.2 → NP_001342394.1  golgin subfamily A member 8S isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC100756
      Conserved Domains (1) summary
      pfam15070
      Location:13 → 402
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

    2. NM_001395373.1 → NP_001382302.1  golgin subfamily A member 8S isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC100756
      Consensus CDS
      CCDS91964.1
      UniProtKB/Swiss-Prot
      H3BPF8
      Related
      ENSP00000455298.2, ENST00000562295.3
      Conserved Domains (1) summary
      COG1196
      Location:109 → 404
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      23354748..23368489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160017.1 Reference GRCh38.p14 PATCHES

      Range
      4303955..4317696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      21091026..21104791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378653.1 → XP_054234628.1  golgin subfamily A member 8S isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_038843.1: Suppressed sequence

      Description
      NR_038843.1: This RefSeq was removed because it is now thought that this locus encodes a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H3BPF8.2 GenPept UniProtKB/Swiss-Prot:H3BPF8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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