U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    P2RX5 purinergic receptor P2X 5 [ Homo sapiens (human) ]

    Gene ID: 5026, updated on 10-Dec-2024

    Summary

    Official Symbol
    P2RX5provided by HGNC
    Official Full Name
    purinergic receptor P2X 5provided by HGNC
    Primary source
    HGNC:HGNC:8536
    See related
    Ensembl:ENSG00000083454 MIM:602836; AllianceGenome:HGNC:8536
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P2X5; LRH-1; P2X5R
    Summary
    The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). [provided by RefSeq, Mar 2011]
    Expression
    Biased expression in lymph node (RPKM 41.6), spleen (RPKM 36.1) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See P2RX5 in Genome Data Viewer
    Location:
    17p13.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (3673227..3723835, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (3562283..3612423, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3576521..3627129, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene P2RX5-TAX1BP3 readthrough (NMD candidate) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3570666-3571197 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:3571198-3571728 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8017 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3572261-3572791 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3572792-3573322 Neighboring gene ribosomal protein L21 pseudogene 125 Neighboring gene Tax1 binding protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3591902-3592810 Neighboring gene ER membrane protein complex subunit 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11513 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3598520-3599036 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8018 Neighboring gene MPRA-validated peak2690 silencer Neighboring gene MPRA-validated peak2691 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:3627127-3627882 Neighboring gene integrin subunit alpha E Neighboring gene Sharpr-MPRA regulatory region 669 Neighboring gene histone H3 associated protein kinase Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:3658435-3659138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11517 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3697478-3698200 Neighboring gene nonconserved acetylation island sequence 85 enhancer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3701060-3701958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3716184-3716689 Neighboring gene nuclear cap binding subunit 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:3735506-3735685 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8020

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of purinergic receptor P2X, ligand-gated ion channel, 5 (P2RX5) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough P2RX5-TAX1BP3

    Readthrough gene: P2RX5-TAX1BP3, Included gene: TAX1BP3

    Clone Names

    • MGC47755

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chloride transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in osteoclast maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of calcium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of calcium ion transport into cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of calcium-mediated signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of skeletal muscle tissue regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ATP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to pH IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to zinc ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    P2X purinoceptor 5
    Names
    ATP receptor subunit
    ionotropic ATP receptor P2X5
    lymphoid-restricted histocompatibility antigen-1
    purinergic receptor P2X, ligand gated ion channel, 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204519.2NP_001191448.1  P2X purinoceptor 5 isoform D

      See identical proteins and their annotated locations for NP_001191448.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (D) that is shorter than isoform A.
      Source sequence(s)
      AK290889, BC028084
      Consensus CDS
      CCDS56015.1
      UniProtKB/TrEMBL
      K7EQ78
      Related
      ENSP00000448355.1, ENST00000547178.5
      Conserved Domains (1) summary
      TIGR00863
      Location:1350
      P2X; cation transporter protein
    2. NM_001204520.2NP_001191449.1  P2X purinoceptor 5 isoform E

      See identical proteins and their annotated locations for NP_001191449.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (E) that is shorter than isoform A.
      Source sequence(s)
      AA805176, AK290889, DQ234349
      Consensus CDS
      CCDS56014.1
      UniProtKB/TrEMBL
      K7EQ78
      Related
      ENSP00000342161.3, ENST00000345901.7
      Conserved Domains (1) summary
      TIGR00863
      Location:1327
      P2X; cation transporter protein
    3. NM_001425082.1NP_001412011.1  P2X purinoceptor 5 isoform G

      Status: REVIEWED

      Source sequence(s)
      AC116914, AC132942
    4. NM_001425083.1NP_001412012.1  P2X purinoceptor 5 isoform G

      Status: REVIEWED

      Source sequence(s)
      AC116914, AC132942
    5. NM_001425084.1NP_001412013.1  P2X purinoceptor 5 isoform G

      Status: REVIEWED

      Source sequence(s)
      AC116914, AC132942
    6. NM_001425085.1NP_001412014.1  P2X purinoceptor 5 isoform G

      Status: REVIEWED

      Source sequence(s)
      AC116914, AC132942
    7. NM_002561.4NP_002552.2  P2X purinoceptor 5 isoform A

      See identical proteins and their annotated locations for NP_002552.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (A).
      Source sequence(s)
      AA805176, AK290889
      Consensus CDS
      CCDS11034.1
      UniProtKB/TrEMBL
      K7EQ78
      Related
      ENSP00000225328.5, ENST00000225328.10
      Conserved Domains (1) summary
      TIGR00863
      Location:1351
      P2X; cation transporter protein
    8. NM_175080.3NP_778255.1  P2X purinoceptor 5 isoform B

      See identical proteins and their annotated locations for NP_778255.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (B) that is shorter than isoform A.
      Source sequence(s)
      AA805176, AF070573, AK290889
      Consensus CDS
      CCDS11035.1
      UniProtKB/TrEMBL
      K7EQ78
      Related
      ENSP00000447545.1, ENST00000551178.5
      Conserved Domains (1) summary
      TIGR00863
      Location:1326
      P2X; cation transporter protein

    RNA

    1. NR_178078.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      CP068261
    2. NR_178079.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      CP068261

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      3673227..3723835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      3562283..3612423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175081.1: Suppressed sequence

      Description
      NM_175081.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.