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    MIR137HG MIR137 host gene [ Homo sapiens (human) ]

    Gene ID: 400765, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MIR137HGprovided by HGNC
    Official Full Name
    MIR137 host geneprovided by HGNC
    Primary source
    HGNC:HGNC:42871
    See related
    Ensembl:ENSG00000225206 AllianceGenome:HGNC:42871
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See MIR137HG in Genome Data Viewer
    Location:
    1p21.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (97988000..98049693, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (97835839..97897607, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (98453556..98515249, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1930 Neighboring gene uncharacterized LOC124904227 Neighboring gene uncharacterized LOC124904228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1110 Neighboring gene uncharacterized LOC124900404 Neighboring gene microRNA 2682 Neighboring gene microRNA 137 Neighboring gene NANOG hESC enhancer GRCh37_chr1:98552438-98552987 Neighboring gene NFU1 iron-sulfur cluster scaffold pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:98670662-98671305 Neighboring gene long intergenic non-protein coding RNA 1776

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Impact of MIR137HG rs7554283 on susceptibility to high-altitude pulmonary edema in the Chinese population. Xu S, et al. Per Med, 2024. PMID 39439230
    2. The effects of MIR137HG genetic polymorphisms on the susceptibility of alcohol-induced osteonecrosis of the femoral head in a Chinese male population. Guo Y, et al. Gene, 2021 Dec 15. PMID 34403773
    3. Polymorphism in schizophrenia risk gene MIR137 is associated with the posterior cingulate Cortex's activation and functional and structural connectivity in healthy controls. Zhang Z, et al. Neuroimage Clin, 2018. PMID 30035013, Free PMC Article
    4. MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia. Patel VS, et al. Neurosci Lett, 2015 Aug 18. PMID 26123324, Free PMC Article
    5. Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia. Wright C, et al. Transl Psychiatry, 2016 Feb 2. PMID 26836412, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Impact of MIR137HG rs7554283 on susceptibility to high-altitude pulmonary edema in the Chinese population.
      Title: Impact of MIR137HG rs7554283 on susceptibility to high-altitude pulmonary edema in the Chinese population.
    2. miR-2682-3p antagonizes its host lncRNA-MIR137HG by interacting with the same target FUS to regulate the progression of gastric cancer.
      Title: miR-2682-3p antagonizes its host lncRNA-MIR137HG by interacting with the same target FUS to regulate the progression of gastric cancer.
    3. Expression of BDNF-Associated lncRNAs in Treatment-Resistant Schizophrenia Patients.
      Title: Expression of BDNF-Associated lncRNAs in Treatment-Resistant Schizophrenia Patients.
    4. The effects of MIR137HG genetic polymorphisms on the susceptibility of alcohol-induced osteonecrosis of the femoral head in a Chinese male population.
      Title: The effects of MIR137HG genetic polymorphisms on the susceptibility of alcohol-induced osteonecrosis of the femoral head in a Chinese male population.
    5. Blood and tissue levels of lncRNAs in periodontitis.
      Title: Blood and tissue levels of lncRNAs in periodontitis.
    6. decreased white matter integrity of the posterior cingulum in risk allele homozygotes of MIR137
      Title: Polymorphism in schizophrenia risk gene MIR137 is associated with the posterior cingulate Cortex's activation and functional and structural connectivity in healthy controls.
    7. Single-nucleotide polymorphism (SNP), rs1625579, within the host gene (MIR137HG) was identified as the top new associated SNP in the first large schizophrenia genome-wide association study.
      Title: Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia.
    8. the mechanisms whereby MIR137HGrv works to increase schizophrenia risk are not those that generate the corpus callosum volume reductions commonly found in the disorder.
      Title: MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog
    Genome-wide association study identifies five new schizophrenia loci.
    EBI GWAS Catalog
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Other Names

    • MIR137 host gene (non-protein coding)

    Clone Names

    • FLJ35409

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in miRNA-mediated post-transcriptional gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RISC complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_046105.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK094607, BX005019, DA791600
      Related
      ENST00000424528.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      97988000..98049693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      97835839..97897607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001001688.1: Suppressed sequence

      Description
      NM_001001688.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials