Myo18a myosin XVIIIA [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myo18aprovided by MGI
Official Full Name: myosin XVIIIAprovided by MGI
Primary source: MGI:MGI:2667185
See related: Ensembl:ENSMUSG00000000631 AllianceGenome:MGI:2667185
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MAJN; MyoPDZ; MysPDZ; SP-R210
Summary: Predicted to enable ADP binding activity; ATP binding activity; and actin filament binding activity. Involved in positive regulation of opsonization and regulation of macrophage activation. Acts upstream of or within cellular response to type II interferon. Located in brush border; cytoskeleton; and phagocytic vesicle. Is expressed in several structures, including gonad; lower leg rest of mesenchyme; molar; musculature; and nervous system. Orthologous to human MYO18A (myosin XVIIIA). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in colon adult (RPKM 16.8), duodenum adult (RPKM 14.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 46.74 cM

Exon count:: 52

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (77654066..77756806)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (77763240..77865988)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disruption of the SP-A/SP-R210L (MYO18Aalpha) pathway prolongs gestation and reduces fetal survival during lipopolysaccharide-induced parturition in late gestation.
Title: Disruption of the SP-A/SP-R210(L) (MYO18Aα) pathway prolongs gestation and reduces fetal survival during lipopolysaccharide-induced parturition in late gestation.
Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation.
Title: Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation.
Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages.
Title: Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages.
Cutting Edge: Myosin 18A Is a Novel Checkpoint Regulator in B Cell Differentiation and Antibody-Mediated Immunity.
Title: Cutting Edge: Myosin 18A Is a Novel Checkpoint Regulator in B Cell Differentiation and Antibody-Mediated Immunity.
Myosin 18Aalpha targets the guanine nucleotide exchange factor beta-Pix to the dendritic spines of cerebellar Purkinje neurons and promotes spine maturation.
Title: Myosin 18Aα targets the guanine nucleotide exchange factor β-Pix to the dendritic spines of cerebellar Purkinje neurons and promotes spine maturation.
we have identified a previously unrecognized sarcomere component, a large novel isoform (denoted Myo18Agamma) of Myo18A. Thus, both members of class XVIII myosins are critical components of cardiac sarcomeres
Title: A novel isoform of myosin 18A (Myo18Aγ) is an essential sarcomeric protein in mouse heart.
MYO18A has the potential to form a multiprotein complex that links the Golgi apparatus to F-actin, which regulates muscle integrity and function during early development
Title: Identification of novel MYO18A interaction partners required for myoblast adhesion and muscle integrity.
studies revealed a novel physical association between SP-R210S, CD14, and SR-A leading to an enhanced response to LPS, and found that SP-R210L and SP-R210S regulate internalization of CD14 via distinct macropinocytosis-like mechanisms
Title: SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation.
Data showed that M18A coassembles with NM2 into mixed bipolar filaments.
Title: Myosin 18A coassembles with nonmuscle myosin 2 to form mixed bipolar filaments.
Mammalian myosin-18A is a highly divergent myosin that does not operate as a traditional molecular motor in cells
Title: Mammalian myosin-18A, a highly divergent myosin.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Bhm40 (e-PCR), detects polymorphism
- UniSTS:141643

D20S837 (e-PCR)
- UniSTS:49002

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

AI790342 (e-PCR)
- UniSTS:165776

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ADP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Golgi organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in Golgi ribbon formation	ISO Inferred from Sequence Orthology more info
involved_in Golgi vesicle budding	ISO Inferred from Sequence Orthology more info
involved_in Golgi vesicle budding	ISS Inferred from Sequence or Structural Similarity more info
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin structure organization	ISO Inferred from Sequence Orthology more info
involved_in actomyosin structure organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in asymmetric Golgi ribbon formation	ISO Inferred from Sequence Orthology more info
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of opsonization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of opsonization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of macrophage activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in actomyosin	ISO Inferred from Sequence Orthology more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum-Golgi intermediate compartment	IEA Inferred from Electronic Annotation more info
located_in microtubule organizing center	IEA Inferred from Electronic Annotation more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: unconventional myosin-XVIIIa

Names: molecule associated with JAK3 N-terminus; myosin XVIIIb; myosin containing a PDZ domain; surfactant protein receptor SP-R210

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291212.2 → NP_001278141.1 unconventional myosin-XVIIIa isoform 3

See identical proteins and their annotated locations for NP_001278141.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.

Source sequence(s)

AL591065

Consensus CDS

CCDS70252.1

UniProtKB/TrEMBL

B2RRE2, K3W4L0

Related

ENSMUSP00000132149.2, ENSMUST00000169105.8

Conserved Domains (3) summary

COG5022
Location:393 → 1907

COG5022; Myosin heavy chain [General function prediction only]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:431 → 1181

MYSc_Myo18; class XVIII myosin, motor domain
NM_001291213.2 → NP_001278142.1 unconventional myosin-XVIIIa isoform 1

See identical proteins and their annotated locations for NP_001278142.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AL591065

Consensus CDS

CCDS70253.1

UniProtKB/TrEMBL

E9QAX2, K3W4L0

Related

ENSMUSP00000130696.2, ENSMUST00000168348.8

Conserved Domains (3) summary

COG5022
Location:429 → 1943

COG5022; Myosin heavy chain [General function prediction only]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:467 → 1217

MYSc_Myo18; class XVIII myosin, motor domain
NM_001291214.2 → NP_001278143.1 unconventional myosin-XVIIIa isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks a portion of the 5' coding region, contains an alternate 5'-terminal exon, uses an alternate start codon, and lacks an exon in the central coding region, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AL591065

Consensus CDS

CCDS78997.1

UniProtKB/TrEMBL

E9Q405, E9QA74

Related

ENSMUSP00000098358.4, ENSMUST00000100794.10

Conserved Domains (2) summary

COG5022
Location:50 → 1560

COG5022; Myosin heavy chain [General function prediction only]

cd01386
Location:88 → 834

MYSc_Myo18; class XVIII myosin, motor domain
NM_001291215.2 → NP_001278144.1 unconventional myosin-XVIIIa isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) contains an alternate 5'-terminal exon and has multiple coding region differences, compared to variant 1. The encoded isoform (5) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AL591065

Consensus CDS

CCDS83849.1

UniProtKB/TrEMBL

A0A1C7ZN10, E9QA74

Related

ENSMUSP00000129098.4, ENSMUST00000172303.10

Conserved Domains (2) summary

COG5022
Location:62 → 1582

COG5022; Myosin heavy chain [General function prediction only]

cd01386
Location:100 → 856

MYSc_Myo18; class XVIII myosin, motor domain
NM_011586.4 → NP_035716.1 unconventional myosin-XVIIIa isoform 2

See identical proteins and their annotated locations for NP_035716.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AL591065

Consensus CDS

CCDS25085.1

UniProtKB/TrEMBL

K3W4L0

Related

ENSMUSP00000090563.5, ENSMUST00000092887.11

Conserved Domains (3) summary

COG5022
Location:381 → 1895

COG5022; Myosin heavy chain [General function prediction only]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:419 → 1169

MYSc_Myo18; class XVIII myosin, motor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

77654066..77756806

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156791.1 → XP_036012684.1 unconventional myosin-XVIIIa isoform X1

Conserved Domains (4) summary

COG5022
Location:429 → 1950

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1782 → 2121

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:467 → 1224

MYSc_Myo18; class XVIII myosin, motor domain
XM_006533596.3 → XP_006533659.1 unconventional myosin-XVIIIa isoform X22

See identical proteins and their annotated locations for XP_006533659.1

UniProtKB/TrEMBL

K3W4L0

Conserved Domains (4) summary

COG5022
Location:429 → 1950

COG5022; Myosin heavy chain [General function prediction only]

PRK03918
Location:1875 → 2040

PRK03918; DNA double-strand break repair ATPase Rad50

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:467 → 1224

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156798.1 → XP_036012691.1 unconventional myosin-XVIIIa isoform X6

UniProtKB/TrEMBL

K3W4L0

Conserved Domains (3) summary

COG5022
Location:429 → 1950

COG5022; Myosin heavy chain [General function prediction only]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:467 → 1224

MYSc_Myo18; class XVIII myosin, motor domain
XM_017314624.2 → XP_017170113.1 unconventional myosin-XVIIIa isoform X24

UniProtKB/TrEMBL

K3W4L0

Conserved Domains (3) summary

COG5022
Location:429 → 1950

COG5022; Myosin heavy chain [General function prediction only]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:467 → 1224

MYSc_Myo18; class XVIII myosin, motor domain
XM_017314623.2 → XP_017170112.1 unconventional myosin-XVIIIa isoform X23

UniProtKB/TrEMBL

K3W4L0

Conserved Domains (4) summary

COG5022
Location:429 → 1939

COG5022; Myosin heavy chain [General function prediction only]

PRK03918
Location:1864 → 2029

PRK03918; DNA double-strand break repair ATPase Rad50

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:467 → 1213

MYSc_Myo18; class XVIII myosin, motor domain
XM_017314625.2 → XP_017170114.1 unconventional myosin-XVIIIa isoform X26

UniProtKB/TrEMBL

K3W4L0

Conserved Domains (3) summary

COG5022
Location:429 → 1939

COG5022; Myosin heavy chain [General function prediction only]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:467 → 1213

MYSc_Myo18; class XVIII myosin, motor domain
XM_030246096.1 → XP_030101956.1 unconventional myosin-XVIIIa isoform X27

UniProtKB/TrEMBL

K3W4L0

Conserved Domains (3) summary

COG5022
Location:393 → 1914

COG5022; Myosin heavy chain [General function prediction only]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:431 → 1188

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156795.1 → XP_036012688.1 unconventional myosin-XVIIIa isoform X3

Conserved Domains (4) summary

COG5022
Location:429 → 1943

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1775 → 2114

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:467 → 1217

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156796.1 → XP_036012689.1 unconventional myosin-XVIIIa isoform X4

Conserved Domains (4) summary

COG5022
Location:429 → 1939

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1771 → 2110

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:467 → 1213

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156800.1 → XP_036012693.1 unconventional myosin-XVIIIa isoform X8

UniProtKB/TrEMBL

K3W4L0

Conserved Domains (4) summary

COG5022
Location:393 → 1914

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1746 → 2085

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:431 → 1188

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156802.1 → XP_036012695.1 unconventional myosin-XVIIIa isoform X10

UniProtKB/TrEMBL

K3W4L0

Conserved Domains (4) summary

COG5022
Location:393 → 1903

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1735 → 2074

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:431 → 1177

MYSc_Myo18; class XVIII myosin, motor domain
XM_006533604.5 → XP_006533667.1 unconventional myosin-XVIIIa isoform X28

See identical proteins and their annotated locations for XP_006533667.1

UniProtKB/Swiss-Prot

Q3TBB2, Q3UH48, Q3UV60, Q5QD54, Q5QD55, Q5QD56, Q5SYN8, Q5SYN9, Q5SYP0, Q5SYP1, Q811D7, Q9JMH9

UniProtKB/TrEMBL

K3W4L0

Related

ENSMUSP00000104012.3, ENSMUST00000108375.9

Conserved Domains (4) summary

COG5022
Location:381 → 1895

COG5022; Myosin heavy chain [General function prediction only]

PRK03918
Location:1820 → 1985

PRK03918; DNA double-strand break repair ATPase Rad50

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:419 → 1169

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156803.1 → XP_036012696.1 unconventional myosin-XVIIIa isoform X11

UniProtKB/TrEMBL

K3W4L0

Conserved Domains (4) summary

COG5022
Location:381 → 1902

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1734 → 2073

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:419 → 1176

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156804.1 → XP_036012697.1 unconventional myosin-XVIIIa isoform X12

UniProtKB/TrEMBL

K3W4L0

Conserved Domains (4) summary

COG5022
Location:381 → 1895

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1727 → 2066

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:419 → 1169

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156805.1 → XP_036012698.1 unconventional myosin-XVIIIa isoform X13

UniProtKB/TrEMBL

K3W4L0

Conserved Domains (4) summary

COG5022
Location:381 → 1891

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1723 → 2062

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:419 → 1165

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156794.1 → XP_036012687.1 unconventional myosin-XVIIIa isoform X1

Conserved Domains (4) summary

COG5022
Location:429 → 1950

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1782 → 2121

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:467 → 1224

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156793.1 → XP_036012686.1 unconventional myosin-XVIIIa isoform X1

Conserved Domains (4) summary

COG5022
Location:429 → 1950

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1782 → 2121

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:467 → 1224

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156813.1 → XP_036012706.1 unconventional myosin-XVIIIa isoform X20

Conserved Domains (3) summary

COG5022
Location:50 → 1571

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1403 → 1742

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd01386
Location:88 → 845

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156814.1 → XP_036012707.1 unconventional myosin-XVIIIa isoform X21

Conserved Domains (3) summary

COG5022
Location:50 → 1564

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1396 → 1735

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd01386
Location:88 → 838

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156806.1 → XP_036012699.1 unconventional myosin-XVIIIa isoform X14

Conserved Domains (4) summary

PHA03307
Location:22 → 305

PHA03307; transcriptional regulator ICP4; Provisional

COG5022
Location:356 → 1877

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1709 → 2048

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd01386
Location:394 → 1151

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156807.1 → XP_036012700.1 unconventional myosin-XVIIIa isoform X15

UniProtKB/TrEMBL

A0A4Y5WWJ7

Conserved Domains (4) summary

PHA03307
Location:22 → 305

PHA03307; transcriptional regulator ICP4; Provisional

COG5022
Location:356 → 1866

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1698 → 2037

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd01386
Location:394 → 1140

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156792.1 → XP_036012685.1 unconventional myosin-XVIIIa isoform X2

Conserved Domains (4) summary

PHA03307
Location:11 → 294

PHA03307; transcriptional regulator ICP4; Provisional

COG5022
Location:345 → 1866

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1698 → 2037

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd01386
Location:383 → 1140

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156797.1 → XP_036012690.1 unconventional myosin-XVIIIa isoform X5

Conserved Domains (4) summary

PHA03307
Location:11 → 294

PHA03307; transcriptional regulator ICP4; Provisional

COG5022
Location:345 → 1855

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1687 → 2026

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd01386
Location:383 → 1129

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156799.1 → XP_036012692.1 unconventional myosin-XVIIIa isoform X7

Conserved Domains (5) summary

PTZ00449
Location:88 → 263

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

COG5022
Location:319 → 1840

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1672 → 2011

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd01386
Location:357 → 1114

MYSc_Myo18; class XVIII myosin, motor domain

cl41730
Location:9 → 119

KLF9_13_N-like; Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins
XM_036156801.1 → XP_036012694.1 unconventional myosin-XVIIIa isoform X9

Conserved Domains (5) summary

PTZ00449
Location:88 → 263

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

COG5022
Location:319 → 1829

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1661 → 2000

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd01386
Location:357 → 1103

MYSc_Myo18; class XVIII myosin, motor domain

cl41730
Location:9 → 119

KLF9_13_N-like; Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins
XM_036156812.1 → XP_036012705.1 unconventional myosin-XVIIIa isoform X19

Conserved Domains (3) summary

COG5022
Location:62 → 1583

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1415 → 1754

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd01386
Location:100 → 857

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156810.1 → XP_036012703.1 unconventional myosin-XVIIIa isoform X17

Conserved Domains (3) summary

COG5022
Location:82 → 1603

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1435 → 1774

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd01386
Location:120 → 877

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156811.1 → XP_036012704.1 unconventional myosin-XVIIIa isoform X18

Conserved Domains (3) summary

COG5022
Location:70 → 1591

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1423 → 1762

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd01386
Location:108 → 865

MYSc_Myo18; class XVIII myosin, motor domain
XM_036156809.1 → XP_036012702.1 unconventional myosin-XVIIIa isoform X16

Conserved Domains (4) summary

PTZ00449
Location:28 → 210

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

COG5022
Location:285 → 1795

COG5022; Myosin heavy chain [General function prediction only]

COG5271
Location:1627 → 1966

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd01386
Location:323 → 1069

MYSc_Myo18; class XVIII myosin, motor domain