Cisd2 CDGSH iron sulfur domain 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cisd2provided by RGD
Official Full Name: CDGSH iron sulfur domain 2provided by RGD
Primary source: RGD:1566242
See related: EnsemblRapid:ENSRNOG00000048258 AllianceGenome:RGD:1566242
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566242
Summary: Predicted to enable 2 iron, 2 sulfur cluster binding activity and protein homodimerization activity. Predicted to be involved in autophagy of mitochondrion and regulation of autophagy. Predicted to be located in endoplasmic reticulum membrane and perinuclear endoplasmic reticulum. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in Wolfram syndrome 2. Orthologous to human CISD2 (CDGSH iron sulfur domain 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 173.6), Brain (RPKM 165.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (226502517..226527325, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (223828937..223853768, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (240586754..240611560, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cisd2 plays an essential role in corneal epithelial regeneration.
Title: Cisd2 plays an essential role in corneal epithelial regeneration.

Submit: New GeneRIF Correction

General gene information

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Markers

RH133566 (e-PCR)
- UniSTS:216849

RH137154 (e-PCR)
- UniSTS:219242

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables 2 iron, 2 sulfur cluster binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy of mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CDGSH iron-sulfur domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191608.3 → NP_001178537.1 CDGSH iron-sulfur domain-containing protein 2

See identical proteins and their annotated locations for NP_001178537.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6HVX1

Related

ENSRNOP00000102562.1, ENSRNOT00000165513.1

Conserved Domains (2) summary

smart00704
Location:81 → 119

ZnF_CDGSH; CDGSH-type zinc finger. Function unknown

pfam10660
Location:3 → 66

MitoNEET_N; Iron-containing outer mitochondrial membrane protein N-terminus