Mrap melanocortin 2 receptor accessory protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mrapprovided by RGD
Official Full Name: melanocortin 2 receptor accessory proteinprovided by RGD
Primary source: RGD:1310648
See related: EnsemblRapid:ENSRNOG00000021524 AllianceGenome:RGD:1310648
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310648
Summary: Predicted to enable identical protein binding activity; melanocortin receptor binding activity; and signaling receptor regulator activity. Predicted to be involved in negative regulation of protein localization to plasma membrane; protein localization to plasma membrane; and regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within brown fat cell differentiation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in endoplasmic reticulum and plasma membrane. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human MRAP (melanocortin 2 receptor accessory protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 1005.2) and Kidney (RPKM 48.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (43477382..43489118)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (29991974..30003024)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (30904733..30915225)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables corticotropin hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 melanocortin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 melanocortin receptor binding	ISO Inferred from Sequence Orthology more info
enables type 3 melanocortin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 3 melanocortin receptor binding	ISO Inferred from Sequence Orthology more info
enables type 4 melanocortin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 4 melanocortin receptor binding	ISO Inferred from Sequence Orthology more info
enables type 5 melanocortin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 5 melanocortin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: melanocortin-2 receptor accessory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135834.1 → NP_001129306.1 melanocortin-2 receptor accessory protein

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

D4A897

Related

ENSRNOP00000102102.1, ENSRNOT00000127610.1

Conserved Domains (1) summary

pfam15183
Location:1 → 89

MRAP; Melanocortin-2 receptor accessory protein family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

43477382..43489118

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270431.1 → XP_063126501.1 melanocortin-2 receptor accessory protein isoform X1
XM_039088214.2 → XP_038944142.1 melanocortin-2 receptor accessory protein isoform X2

Conserved Domains (1) summary

pfam15183
Location:39 → 73

MRAP; Melanocortin-2 receptor accessory protein family
XM_039088215.2 → XP_038944143.1 melanocortin-2 receptor accessory protein isoform X3

Conserved Domains (1) summary

pfam15183
Location:39 → 105

MRAP; Melanocortin-2 receptor accessory protein family