Serpina3c serine (or cysteine) proteinase inhibitor, clade A, member 3C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Serpina3cprovided by RGD
Official Full Name: serine (or cysteine) proteinase inhibitor, clade A, member 3Cprovided by RGD
Primary source: RGD:2972
See related: EnsemblRapid:ENSRNOG00000010410 AllianceGenome:RGD:2972
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kbp; SPI2; Klkbp; SPI-2; Spin2; CPi-21; Spin2b; GHR-P63; SPI-2.3; Serpina3k
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Involved in negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; and positive regulation of apoptotic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 23764.1) See more
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Genomic context

Location:: 6q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (129007578..129014988, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (123240251..123250219, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (127996162..128003433, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transient response of serpinA3 during cellular stress.
Title: Transient response of serpinA3 during cellular stress.
KBP suppressed lipopolysaccharide-induced TNF-alpha production via upregulating SOCS3 expression.
Title: Kallikrein-binding protein inhibits LPS-induced TNF-α by upregulating SOCS3 expression.
KBP competed with (125)I-VEGF for binding to endothelial cells and down-regulated VEGF production in endothelial cells and in the retina of the oxygen-induced retinopathy rat model
Title: Kallikrein-binding protein inhibits retinal neovascularization and decreases vascular leakage.
An inverse relationship exists between oxidative stress and kallistatin levels in the circulation and blood vessels. Kallistatin expression is negatively regulated by oxidative stress via JNK-dependent FOXO1 activation in cultured endothelial cells.
Title: Pivotal role of JNK-dependent FOXO1 activation in downregulation of kallistatin expression by oxidative stress.
in a rat model of chronic mycardial infarction (MI) kallistatin improves cardiac performance and prevents post-MI-induced cardiac hypertrophy and fibrosis through its antioxidant action.
Title: Role of kallistatin in prevention of cardiac remodeling after chronic myocardial infarction.
Pivotal role for alpha1-antichymotrypsin in skin repair
Title: Pivotal role for alpha1-antichymotrypsin in skin repair.
SERPINA3K is an antifibrogenic factor, and its antifibrogenic activity is through blocking the Wnt pathway. Decreased SERPINA3K levels may contribute to the fibrosis in diabetic retinopathy.
Title: Inhibition of connective tissue growth factor overexpression in diabetic retinopathy by SERPINA3K via blocking the WNT/beta-catenin pathway.
SERPINA3K is a high-affinity, endogenous antagonist of LRP6
Title: Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine protease inhibitor A3K

Names: contrapsin-like protease inhibitor 1; growth hormone-regulated proteinase inhibitor; kallikrein-binding protein; kallistatin; serine (or cysteine) peptidase inhibitor, clade A, member 3K; serine protease inhibitor 2; serine protease inhibitor 2b; serpin A3K; thyroid hormone-regulated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.