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    Gkap1 G kinase anchoring protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361202, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gkap1provided by RGD
    Official Full Name
    G kinase anchoring protein 1provided by RGD
    Primary source
    RGD:1306955
    See related
    EnsemblRapid:ENSRNOG00000019272 AllianceGenome:RGD:1306955
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in positive regulation of insulin receptor signaling pathway and signal transduction. Predicted to be located in Golgi apparatus. Orthologous to human GKAP1 (G kinase anchoring protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 891.0), Muscle (RPKM 170.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gkap1 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (6389377..6429091)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (6383963..6423684)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (6785428..6825145)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene Q-nucleotide N-glycosylase 1 Neighboring gene kinesin family member 27 like 1 Neighboring gene kinesin family member 27 Neighboring gene uncharacterized LOC134482805 Neighboring gene small nucleolar RNA SNORD113/SNORD114 family Neighboring gene ubiquilin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tumor necrosis factor (TNF)-α-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Iα causes insulin resistance in 3T3-L1 adipocytes. Ando Y, et al. J Biol Chem, 2015 Feb 27. PMID 25586176, Free PMC Article
    2. Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha. Yuasa K, et al. J Biol Chem, 2000 Feb 18. PMID 10671526
    3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    G kinase-anchoring protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012160.1 → NP_001012160.1  G kinase-anchoring protein 1

      See identical proteins and their annotated locations for NP_001012160.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083717
      UniProtKB/Swiss-Prot
      Q5XIG5
      Related
      ENSRNOP00000111076.1, ENSRNOT00000167779.1
      Conserved Domains (1) summary
      COG1196
      Location:217 → 349
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      6389377..6429091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276552.1 → XP_063132622.1  G kinase-anchoring protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QDT6
      Related
      ENSRNOP00000026070.6, ENSRNOT00000026070.8

    2. XM_063276553.1 → XP_063132623.1  G kinase-anchoring protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8L2RA95
      Related
      ENSRNOP00000075132.2, ENSRNOT00000083408.3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIG5.1 GenPept UniProtKB/Swiss-Prot:Q5XIG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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