Slc18b1 solute carrier family 18 member B1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc18b1provided by RGD
Official Full Name: solute carrier family 18 member B1provided by RGD
Primary source: RGD:1306962
See related: EnsemblRapid:ENSRNOG00000016371 AllianceGenome:RGD:1306962
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: VPAT; RGD1306962
Summary: Predicted to enable monoamine:proton antiporter activity and polyamine:proton antiporter activity. Predicted to be involved in serotonin uptake; spermidine transport; and spermine transport. Located in synaptic vesicle membrane. Orthologous to human SLC18B1 (solute carrier family 18 member B1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 64.7), Brain (RPKM 50.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (23447462..23490043, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (21628235..21670807, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (22705980..22748571, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VPAT is expressed and is responsible for vesicular storage of spermine and spermidine in novel secretory granules that differ from histamine- and serotonin-containing granules and is involved in vesicular release of these polyamines from mast cells
Title: Vesicular Polyamine Transporter Mediates Vesicular Storage and Release of Polyamine from Mast Cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables monoamine:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables monoamine:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables polyamine:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables polyamine:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in polyamine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in serotonin uptake	ISO Inferred from Sequence Orthology more info
involved_in serotonin uptake	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermidine transport	ISO Inferred from Sequence Orthology more info
involved_in spermidine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermine transport	ISO Inferred from Sequence Orthology more info
involved_in spermine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in secretory granule membrane	ISO Inferred from Sequence Orthology more info
located_in secretory granule membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: MFS-type transporter SLC18B1

Names: solute carrier family 18, subfamily B, member 1; vesicular polyamine transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.