WWP2 WW domain containing E3 ubiquitin protein ligase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: WWP2provided by HGNC
Official Full Name: WW domain containing E3 ubiquitin protein ligase 2provided by HGNC
Primary source: HGNC:HGNC:16804
See related: Ensembl:ENSG00000198373 MIM:602308; AllianceGenome:HGNC:16804
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AIP2; WWp2-like
Summary: This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]
Expression: Ubiquitous expression in lung (RPKM 8.8), spleen (RPKM 8.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16q22.1

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (69762332..69941739)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (75564847..75744318)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (69796235..69975642)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WWP2 binds to NKRF, enhances the NF-kappaB signaling, and promotes malignant phenotypes of acute myeloid leukemia cells.
Title: WWP2 binds to NKRF, enhances the NF-κB signaling, and promotes malignant phenotypes of acute myeloid leukemia cells.
Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1.
Title: Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1.
Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X.
Title: Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X.
WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein.
Title: WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein.
lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1.
Title: lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1.
WWP2 confers risk to osteoarthritis by affecting cartilage matrix deposition via hypoxia associated genes.
Title: WWP2 confers risk to osteoarthritis by affecting cartilage matrix deposition via hypoxia associated genes.
The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis.
Title: The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis.
miR-328-5p Induces Human Intervertebral Disc Degeneration by Targeting WWP2.
Title: miR-328-5p Induces Human Intervertebral Disc Degeneration by Targeting WWP2.
WWP2 ameliorates oxidative stress and inflammation in atherosclerotic mice through regulation of PDCD4/HO-1 pathway.
Title: WWP2 ameliorates oxidative stress and inflammation in atherosclerotic mice through regulation of PDCD4/HO-1 pathway.
WWP2 overexpression inhibits the antitumor effects of doxorubicin in hepatocellular carcinoma.
Title: WWP2 overexpression inhibits the antitumor effects of doxorubicin in hepatocellular carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D16S3095 (e-PCR), detects polymorphism
- UniSTS:65286

MARC_17527-17528:1016478546:1 (e-PCR)
- UniSTS:268331

RH69974 (e-PCR)
- UniSTS:71239

RH68624 (e-PCR)
- UniSTS:69989

G69462 (e-PCR)
- UniSTS:229536

SHGC-153661 (e-PCR)
- UniSTS:177868

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	TAS Traceable Author Statement more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in extracellular transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of Notch signaling pathway	TAS Traceable Author Statement more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of transporter activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein K63-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein modification process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of monoatomic ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of potassium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
involved_in symbiont entry into host cell	TAS Traceable Author Statement more info	PubMed
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of ubiquitin ligase complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: NEDD4-like E3 ubiquitin-protein ligase WWP2

Names: HECT-type E3 ubiquitin transferase WWP2; atrophin-1 interacting protein 2

NP_001257382.1

EC 2.3.2.26

NP_001257383.1

EC 2.3.2.26

NP_001257384.1

EC 2.3.2.26

NP_008945.2

EC 2.3.2.26

NP_955456.1

EC 2.3.2.26

XP_011521125.1

EC 2.3.2.26

XP_011521127.1

EC 2.3.2.26

XP_011521128.1

EC 2.3.2.26

XP_016878368.1

EC 2.3.2.26

XP_016878369.1

EC 2.3.2.26

XP_016878370.1

EC 2.3.2.26

XP_047289476.1

EC 2.3.2.26

XP_047289477.1

EC 2.3.2.26

XP_047289478.1

EC 2.3.2.26

XP_047289479.1

EC 2.3.2.26

XP_047289480.1

EC 2.3.2.26

XP_054235396.1

EC 2.3.2.26

XP_054235397.1

EC 2.3.2.26

XP_054235398.1

EC 2.3.2.26

XP_054235399.1

EC 2.3.2.26

XP_054235400.1

EC 2.3.2.26

XP_054235401.1

EC 2.3.2.26

XP_054235402.1

EC 2.3.2.26

XP_054235403.1

EC 2.3.2.26

XP_054235404.1

EC 2.3.2.26

XP_054235405.1

EC 2.3.2.26

XP_054235406.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270453.2 → NP_001257382.1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform 4

See identical proteins and their annotated locations for NP_001257382.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK300266, AK316097, JN712744

Consensus CDS

CCDS58476.1

UniProtKB/TrEMBL

B4DIN7

Related

ENSP00000348283.3, ENST00000356003.6

Conserved Domains (5) summary

smart00119
Location:423 → 751

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:400 → 752

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00201
Location:331 → 361

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:216 → 245

WW; WW domain

cl14603
Location:1 → 26

C2; C2 domain
NM_001270454.2 → NP_001257383.1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform WWP2-FL

See identical proteins and their annotated locations for NP_001257383.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1 and 5 encode the same isoform (WWP2-FL).

Source sequence(s)

JN712744

Consensus CDS

CCDS10885.1

UniProtKB/Swiss-Prot

A6NEP1, B2R706, B4DTL5, F5H213, H3BRF3, I3RSG8, O00308, Q6ZTQ5, Q96CZ2, Q9BWN6

UniProtKB/TrEMBL

B4DIN7

Related

ENSP00000352069.2, ENST00000359154.7

Conserved Domains (5) summary

cd04021
Location:17 → 142

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

cd00078
Location:516 → 868

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00201
Location:447 → 477

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:332 → 361

WW; WW domain

cl26464
Location:164 → 343

Atrophin-1; Atrophin-1 family
NM_001270455.2 → NP_001257384.1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform WWP2-N

See identical proteins and their annotated locations for NP_001257384.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 3' UTR, compared to variant 1. The encoded isoform (WWP2-N) has a shorter C-terminus, compared to isoform 1.

Source sequence(s)

AC026468, BC000108, DC402912

Consensus CDS

CCDS58475.1

UniProtKB/Swiss-Prot

O00308

Related

ENSP00000455311.1, ENST00000569174.5

Conserved Domains (3) summary

cd04021
Location:17 → 142

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

pfam00397
Location:302 → 331

WW; WW domain

cl27169
Location:189 → 308

ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...
NM_007014.5 → NP_008945.2 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform WWP2-FL

See identical proteins and their annotated locations for NP_008945.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (WWP2-FL). Variants 1 and 5 encode the same isoform.

Source sequence(s)

DC402912, JN712744, U96114

Consensus CDS

CCDS10885.1

UniProtKB/Swiss-Prot

A6NEP1, B2R706, B4DTL5, F5H213, H3BRF3, I3RSG8, O00308, Q6ZTQ5, Q96CZ2, Q9BWN6

UniProtKB/TrEMBL

B4DIN7

Conserved Domains (5) summary

cd04021
Location:17 → 142

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

cd00078
Location:516 → 868

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00201
Location:447 → 477

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:332 → 361

WW; WW domain

cl26464
Location:164 → 343

Atrophin-1; Atrophin-1 family
NM_199424.3 → NP_955456.1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform WWP2-C

See identical proteins and their annotated locations for NP_955456.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a large portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (WWP2-C) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK126332, AK316097, JN712744

Consensus CDS

CCDS58477.1

UniProtKB/TrEMBL

B4DHF6

Related

ENSP00000456216.1, ENST00000568684.1

Conserved Domains (3) summary

smart00119
Location:100 → 428

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:77 → 429

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00201
Location:8 → 38

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

69762332..69941739

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017022879.2 → XP_016878368.1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

UniProtKB/Swiss-Prot

A6NEP1, B2R706, B4DTL5, F5H213, H3BRF3, I3RSG8, O00308, Q6ZTQ5, Q96CZ2, Q9BWN6

UniProtKB/TrEMBL

B4DIN7

Conserved Domains (5) summary

cd04021
Location:17 → 142

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

cd00078
Location:516 → 868

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00201
Location:447 → 477

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:332 → 361

WW; WW domain

cl26464
Location:164 → 343

Atrophin-1; Atrophin-1 family
XM_017022881.2 → XP_016878370.1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

UniProtKB/Swiss-Prot

A6NEP1, B2R706, B4DTL5, F5H213, H3BRF3, I3RSG8, O00308, Q6ZTQ5, Q96CZ2, Q9BWN6

UniProtKB/TrEMBL

B4DIN7

Conserved Domains (5) summary

cd04021
Location:17 → 142

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

cd00078
Location:516 → 868

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00201
Location:447 → 477

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:332 → 361

WW; WW domain

cl26464
Location:164 → 343

Atrophin-1; Atrophin-1 family
XM_011522823.3 → XP_011521125.1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

See identical proteins and their annotated locations for XP_011521125.1

UniProtKB/Swiss-Prot

A6NEP1, B2R706, B4DTL5, F5H213, H3BRF3, I3RSG8, O00308, Q6ZTQ5, Q96CZ2, Q9BWN6

UniProtKB/TrEMBL

B4DIN7

Conserved Domains (5) summary

cd04021
Location:17 → 142

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

cd00078
Location:516 → 868

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00201
Location:447 → 477

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:332 → 361

WW; WW domain

cl26464
Location:164 → 343

Atrophin-1; Atrophin-1 family
XM_011522825.2 → XP_011521127.1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

See identical proteins and their annotated locations for XP_011521127.1

UniProtKB/Swiss-Prot

A6NEP1, B2R706, B4DTL5, F5H213, H3BRF3, I3RSG8, O00308, Q6ZTQ5, Q96CZ2, Q9BWN6

UniProtKB/TrEMBL

B4DIN7

Conserved Domains (5) summary

cd04021
Location:17 → 142

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

cd00078
Location:516 → 868

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00201
Location:447 → 477

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:332 → 361

WW; WW domain

cl26464
Location:164 → 343

Atrophin-1; Atrophin-1 family
XM_047433520.1 → XP_047289476.1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

UniProtKB/Swiss-Prot

A6NEP1, B2R706, B4DTL5, F5H213, H3BRF3, I3RSG8, O00308, Q6ZTQ5, Q96CZ2, Q9BWN6
XM_047433522.1 → XP_047289478.1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

UniProtKB/Swiss-Prot

A6NEP1, B2R706, B4DTL5, F5H213, H3BRF3, I3RSG8, O00308, Q6ZTQ5, Q96CZ2, Q9BWN6
XM_047433523.1 → XP_047289479.1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

UniProtKB/Swiss-Prot

A6NEP1, B2R706, B4DTL5, F5H213, H3BRF3, I3RSG8, O00308, Q6ZTQ5, Q96CZ2, Q9BWN6
XM_017022880.2 → XP_016878369.1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

UniProtKB/Swiss-Prot

A6NEP1, B2R706, B4DTL5, F5H213, H3BRF3, I3RSG8, O00308, Q6ZTQ5, Q96CZ2, Q9BWN6

UniProtKB/TrEMBL

B4DIN7

Conserved Domains (5) summary

cd04021
Location:17 → 142

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

cd00078
Location:516 → 868

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00201
Location:447 → 477

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:332 → 361

WW; WW domain

cl26464
Location:164 → 343

Atrophin-1; Atrophin-1 family
XM_047433521.1 → XP_047289477.1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

UniProtKB/Swiss-Prot

A6NEP1, B2R706, B4DTL5, F5H213, H3BRF3, I3RSG8, O00308, Q6ZTQ5, Q96CZ2, Q9BWN6
XM_047433524.1 → XP_047289480.1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X2
XM_011522826.4 → XP_011521128.1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X2

See identical proteins and their annotated locations for XP_011521128.1

UniProtKB/TrEMBL

B4DIN7

Conserved Domains (5) summary

smart00119
Location:423 → 751

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:400 → 752

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00201
Location:331 → 361

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:216 → 245

WW; WW domain

cl14603
Location:1 → 26

C2; C2 domain