RPPH1 ribonuclease P RNA component H1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RPPH1provided by HGNC
Official Full Name: ribonuclease P RNA component H1provided by HGNC
Primary source: HGNC:HGNC:19273
See related: Ensembl:ENSG00000277209 MIM:608513; AllianceGenome:HGNC:19273
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: H1RNA; RPPH1-1
Summary: H1RNA is the RNA component of the RNase P ribonucleoprotein, an endoribonuclease that cleaves tRNA precursor molecules to form the mature 5-prime termini of their tRNA sequences (Baer et al., 1989 [PubMed 2308839]).[supplied by OMIM, Mar 2008]
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Genomic context

Location:: 14q11.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (20343071..20343411, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (14539966..14540306, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (20811230..20811570, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circ_RPPH1 facilitates progression of breast cancer via miR-1296-5p/TRIM14 axis.
Title: Circ_RPPH1 facilitates progression of breast cancer via miR-1296-5p/TRIM14 axis.
The long non-coding RPPH1 is decreased in leukocytes and increased in plasma from women developing pre-eclampsiadagger.
Title: The long non-coding RPPH1 is decreased in leukocytes and increased in plasma from women developing pre-eclampsia†.
Diagnostic and prognostic value of deregulated long non-coding RNA RPPH1 in patients with severe community-acquired pneumonia: a retrospective cohort study.
Title: Diagnostic and prognostic value of deregulated long non-coding RNA RPPH1 in patients with severe community-acquired pneumonia: a retrospective cohort study.
C-Fos-activated circRPPH1 contributes to glioma stemness.
Title: C-Fos-activated circRPPH1 contributes to glioma stemness.
LncRNA RPPH1 acts as a molecular sponge for miR-122 to regulate Wnt1/beta-catenin signaling in hepatocellular carcinoma.
Title: LncRNA RPPH1 acts as a molecular sponge for miR-122 to regulate Wnt1/β-catenin signaling in hepatocellular carcinoma.
CircRPPH1 promotes the stemness of gastric cancer cells by targeting miR-375/SLC7A11 axis.
Title: CircRPPH1 promotes the stemness of gastric cancer cells by targeting miR-375/SLC7A11 axis.
Mediation of circ_RPPH1 on miR-146b-3p/E2F2 pathway to hinder the growth and metastasis of breast carcinoma cells.
Title: Mediation of circ_RPPH1 on miR-146b-3p/E2F2 pathway to hinder the growth and metastasis of breast carcinoma cells.
PUM1 and RNase P genes as potential cell-free DNA markers in breast cancer.
Title: PUM1 and RNase P genes as potential cell-free DNA markers in breast cancer.
LncRNA RPPH1 attenuates Abeta25-35-induced endoplasmic reticulum stress and apoptosis in SH-SY5Y cells via miR-326/PKM2.
Title: LncRNA RPPH1 attenuates Aβ(25-35)-induced endoplasmic reticulum stress and apoptosis in SH-SY5Y cells via miR-326/PKM2.
Accumulation of Mitochondrial RPPH1 RNA Is Associated with Cellular Senescence.
Title: Accumulation of Mitochondrial RPPH1 RNA Is Associated with Cellular Senescence.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ribonuclease P activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ribonuclease P complex	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.