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    APLP2 amyloid beta precursor like protein 2 [ Homo sapiens (human) ]

    Gene ID: 334, updated on 10-Dec-2024

    Summary

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    Official Symbol
    APLP2provided by HGNC
    Official Full Name
    amyloid beta precursor like protein 2provided by HGNC
    Primary source
    HGNC:HGNC:598
    See related
    Ensembl:ENSG00000084234 MIM:104776; AllianceGenome:HGNC:598
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APPH; APPL2; CDEBP; APLP-2
    Summary
    This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 347.8), lung (RPKM 236.7) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See APLP2 in Genome Data Viewer
    Location:
    11q24.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (130069894..130144805)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (130106007..130180474)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (129939789..130014700)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13105 Neighboring gene NANOG hESC enhancer GRCh37_chr11:129907707-129908249 Neighboring gene MPRA-validated peak1512 silencer Neighboring gene elongin B pseudogene 2 Neighboring gene uncharacterized LOC107984432 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:129938480-129938980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:129938981-129939481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4076 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4077 Neighboring gene ribosomal protein L34 pseudogene 21 Neighboring gene MPRA-validated peak1513 silencer Neighboring gene uncharacterized LOC124902850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:129993119-129993620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:129993621-129994120 Neighboring gene Sharpr-MPRA regulatory region 10235 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:130015754-130016953 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4079 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:130030913-130031412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5752 Neighboring gene ST14 transmembrane serine protease matriptase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:130068001-130068502 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:130079505-130080004 Neighboring gene zinc finger and BTB domain containing 44 Neighboring gene NDUFAF2 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Post-translational processing and turnover kinetics of presynaptically targeted amyloid precursor superfamily proteins in the central nervous system. Lyckman AW, et al. J Biol Chem, 1998 May 1. PMID 9556595
    2. The APP family of proteins: similarities and differences. Walsh DM, et al. Biochem Soc Trans, 2007 Apr. PMID 17371289
    3. Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells. Peters HL, et al. Int J Oncol, 2012 Oct. PMID 22797723, Free PMC Article
    4. APLP2 gene polymorphisms are associated with high TC and LDL-C levels in Chinese population in Xinjiang, China. Abuzhalihan J, et al. Biosci Rep, 2020 Aug 28. PMID 32716039, Free PMC Article
    5. YWK-II protein as a novel G(o)-coupled receptor for Müllerian inhibiting substance in cell survival. Yin X, et al. J Cell Sci, 2007 May 1. PMID 17452623

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comprehensive intratumoral heterogeneity landscaping of liver hepatocellular carcinoma and discerning of APLP2 in cancer progression.
      Title: Comprehensive intratumoral heterogeneity landscaping of liver hepatocellular carcinoma and discerning of APLP2 in cancer progression.
    2. Implication of Amyloid Precursor-like Protein 2 Expression in Cutaneous Squamous Cell Carcinoma Pathogenesis.
      Title: Implication of Amyloid Precursor-like Protein 2 Expression in Cutaneous Squamous Cell Carcinoma Pathogenesis.
    3. Mycobacterium tuberculosis suppresses APLP2 expression to enhance its survival in macrophage.
      Title: Mycobacterium tuberculosis suppresses APLP2 expression to enhance its survival in macrophage.
    4. APLP2 is predominantly cleaved by beta-secretase and gamma-secretase in the human brain.
      Title: APLP2 is predominantly cleaved by β-secretase and γ-secretase in the human brain.
    5. APLP2 gene polymorphisms are associated with high TC and LDL-C levels in Chinese population in Xinjiang, China.
      Title: APLP2 gene polymorphisms are associated with high TC and LDL-C levels in Chinese population in Xinjiang, China.
    6. our findings indicate that beta2m regulates pancreatic cancer cell migration, and furthermore suggest that APLP2 is an intermediary in this process.
      Title: Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells.
    7. the expression of APLP2 might correlate with tumor development and be a prognostic factor for patients with glioblastoma
      Title: Expression of amyloid precursor-like protein 2 (APLP2) in glioblastoma is associated with patient prognosis.
    8. These findings suggest that the identified APLP2, RRM2, and PRC1 signature could be useful for distinguishing between benign (follicular adenoma) and malignant (follicular carcionma and follicular variant of papillary carcinoma) tumors of the thyroid follicular epithelium.
      Title: APLP2, RRM2, and PRC1: New Putative Markers for the Differential Diagnosis of Thyroid Follicular Lesions.
    9. This paper demonstrates an important role for APLP2 in refractive development in mice and humans, suggesting a high level of evolutionary conservation of the signaling pathways underlying refractive eye development.
      Title: APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans.
    10. Data show that amyloid precursor-like protein 2 (APLP2) expression is elevated in pancreatic cancer metastases.
      Title: Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: ST14

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in membrane HDA PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in platelet alpha granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    amyloid beta precursor like protein 2
    Names
    CDEI box-binding protein
    amyloid beta (A4) precursor-like protein 2
    amyloid precursor protein homolog HSD-2
    sperm membrane protein YWK-II
    testicular tissue protein Li 23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029770.1 RefSeqGene

      Range
      5074..79985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001142276.2 → NP_001135748.1  amyloid beta precursor like protein 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001135748.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2 which lacks an internal segment in the C-terminal region, compared to isoform 1.
      Source sequence(s)
      AK056883, BC000373, BM992563, DC336210
      Consensus CDS
      CCDS44773.1
      UniProtKB/TrEMBL
      A0A140VJE9, B4E3I5
      Related
      ENSP00000345444.5, ENST00000338167.10
      Conserved Domains (6) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:49 → 147
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:697 → 747
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:149 → 204
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:365 → 547
      APP_E2; E2 domain of amyloid precursor protein

    2. NM_001142277.2 → NP_001135749.1  amyloid beta precursor like protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001135749.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the coding region, compared to variant 1. It encodes isoform 3 which lacks two internal segments, compared to isoform 1.
      Source sequence(s)
      AK056883, AK304736, BM992563, DC336210
      Consensus CDS
      CCDS44774.1
      UniProtKB/TrEMBL
      B4E3I5
      Related
      ENSP00000435914.1, ENST00000528499.5
      Conserved Domains (5) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam02177
      Location:49 → 147
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:641 → 691
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:149 → 204
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:309 → 491
      APP_E2; E2 domain of amyloid precursor protein

    3. NM_001142278.2 → NP_001135750.1  amyloid beta precursor like protein 2 isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks multiple exons in the coding region, compared to variant 1. The reading frame is not affected, and this variant encodes isoform 4 which lacks two internal segments, compared to isoform 1.
      Source sequence(s)
      AK056883, BC004371, BM992563, DC336210
      Consensus CDS
      CCDS44775.1
      UniProtKB/Swiss-Prot
      Q06481
      Related
      ENSP00000263575.6, ENST00000345598.9
      Conserved Domains (3) summary
      pfam10515
      Location:468 → 518
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:136 → 318
      APP_E2; E2 domain of amyloid precursor protein
      cl26273
      Location:42 → 137
      APP_N; Amyloid A4 N-terminal heparin-binding

    4. NM_001243299.2 → NP_001230228.1  amyloid beta precursor like protein 2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' exon and also lacks an in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 5 which has a different N-terminus and lacks an internal segment in the C-terminal region, compared to isoform 1.
      Source sequence(s)
      AK056883, AK128162, BC000373, BM992563
      Consensus CDS
      CCDS58196.1
      UniProtKB/TrEMBL
      B4E3I5
      Related
      ENSP00000278756.7, ENST00000278756.7
      Conserved Domains (6) summary
      smart00006
      Location:52 → 214
      A4_EXTRA; amyloid A4
      pfam00014
      Location:319 → 371
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:59 → 157
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:707 → 757
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:159 → 214
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:375 → 557
      APP_E2; E2 domain of amyloid precursor protein

    5. NM_001328682.2 → NP_001315611.1  amyloid beta precursor like protein 2 isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041, BM992563
      UniProtKB/TrEMBL
      B4E3I5

    6. NM_001328684.2 → NP_001315613.1  amyloid beta precursor like protein 2 isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041, BM992563
      UniProtKB/TrEMBL
      B4E3I5

    7. NM_001328685.2 → NP_001315614.1  amyloid beta precursor like protein 2 isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041, BM992563
      UniProtKB/TrEMBL
      B4E3I5

    8. NM_001328686.2 → NP_001315615.1  amyloid beta precursor like protein 2 isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041, BM992563
      UniProtKB/TrEMBL
      B4E3I5

    9. NM_001382526.1 → NP_001369455.1  amyloid beta precursor like protein 2 isoform 10 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (4) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:365 → 545
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:678 → 758
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    10. NM_001382527.1 → NP_001369456.1  amyloid beta precursor like protein 2 isoform 11 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (4) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:365 → 547
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:680 → 758
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    11. NM_001382528.1 → NP_001369457.1  amyloid beta precursor like protein 2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5

    12. NM_001382529.1 → NP_001369458.1  amyloid beta precursor like protein 2 isoform 13 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (3) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      COG4942
      Location:407 → 579
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00109
      Location:308 → 361
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    13. NM_001382530.1 → NP_001369459.1  amyloid beta precursor like protein 2 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (4) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:365 → 547
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:643 → 723
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    14. NM_001382531.1 → NP_001369460.1  amyloid beta precursor like protein 2 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (4) summary
      smart00006
      Location:42 → 171
      A4_EXTRA; amyloid A4
      pfam00014
      Location:265 → 317
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:321 → 503
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:636 → 716
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    15. NM_001382532.1 → NP_001369461.1  amyloid beta precursor like protein 2 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (4) summary
      smart00006
      Location:42 → 173
      A4_EXTRA; amyloid A4
      pfam00014
      Location:276 → 328
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:332 → 514
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:635 → 715
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    16. NM_001382533.1 → NP_001369462.1  amyloid beta precursor like protein 2 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (4) summary
      smart00006
      Location:35 → 146
      A4_EXTRA; amyloid A4
      pfam00014
      Location:251 → 303
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:307 → 489
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:622 → 702
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    17. NM_001382534.1 → NP_001369463.1  amyloid beta precursor like protein 2 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (3) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam12925
      Location:309 → 485
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:618 → 698
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    18. NM_001382535.1 → NP_001369464.1  amyloid beta precursor like protein 2 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (3) summary
      smart00006
      Location:42 → 209
      A4_EXTRA; amyloid A4
      pfam12925
      Location:314 → 496
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:617 → 697
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    19. NM_001382536.1 → NP_001369465.1  amyloid beta precursor like protein 2 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (4) summary
      smart00006
      Location:35 → 146
      A4_EXTRA; amyloid A4
      pfam00014
      Location:251 → 303
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:307 → 489
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:610 → 690
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    20. NM_001382537.1 → NP_001369466.1  amyloid beta precursor like protein 2 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (3) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam12925
      Location:309 → 464
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:585 → 665
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    21. NM_001382538.1 → NP_001369467.1  amyloid beta precursor like protein 2 isoform 22 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (4) summary
      smart00006
      Location:42 → 112
      A4_EXTRA; amyloid A4
      pfam00014
      Location:213 → 265
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:269 → 451
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:572 → 652
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    22. NM_001382539.1 → NP_001369468.1  amyloid beta precursor like protein 2 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5

    23. NM_001382540.1 → NP_001369469.1  amyloid beta precursor like protein 2 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (3) summary
      smart00006
      Location:35 → 146
      A4_EXTRA; amyloid A4
      pfam12925
      Location:251 → 433
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:554 → 634
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    24. NM_001382541.1 → NP_001369470.1  amyloid beta precursor like protein 2 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (3) summary
      smart00006
      Location:42 → 112
      A4_EXTRA; amyloid A4
      pfam12925
      Location:213 → 395
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:528 → 608
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    25. NM_001382542.1 → NP_001369471.1  amyloid beta precursor like protein 2 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4DTV1
      Conserved Domains (4) summary
      pfam00014
      Location:153 → 205
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12924
      Location:1 → 48
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:209 → 391
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:524 → 604
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    26. NM_001382543.1 → NP_001369472.1  amyloid beta precursor like protein 2 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (3) summary
      smart00006
      Location:42 → 112
      A4_EXTRA; amyloid A4
      pfam12925
      Location:213 → 395
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:516 → 596
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    27. NM_001382544.1 → NP_001369473.1  amyloid beta precursor like protein 2 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (3) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam12925
      Location:270 → 362
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:483 → 563
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    28. NM_001382545.1 → NP_001369474.1  amyloid beta precursor like protein 2 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      Conserved Domains (3) summary
      smart00006
      Location:42 → 112
      A4_EXTRA; amyloid A4
      pfam12925
      Location:213 → 395
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:465 → 545
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    29. NM_001382546.1 → NP_001369475.1  amyloid beta precursor like protein 2 isoform 30 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      Conserved Domains (3) summary
      smart00006
      Location:42 → 137
      A4_EXTRA; amyloid A4
      pfam12925
      Location:136 → 318
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:451 → 531
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    30. NM_001642.3 → NP_001633.1  amyloid beta precursor like protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001633.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK056883, BM992563, DC336210, Z22572
      Consensus CDS
      CCDS8486.1
      UniProtKB/Swiss-Prot
      B3KXX9, H7BXI4, Q06481, Q13861, Q14594, Q14662, Q71U10, Q7M4L3, Q9BT36
      UniProtKB/TrEMBL
      B4E3I5
      Related
      ENSP00000263574.5, ENST00000263574.9
      Conserved Domains (6) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:49 → 147
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:709 → 759
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:149 → 204
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:365 → 547
      APP_E2; E2 domain of amyloid precursor protein

    RNA

    1. NR_024515.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in multiple regions, compared to variant 1. The transcript is a candidate for nonsense-mediated decay (NMD).
      Source sequence(s)
      AK056883, BM992563, Z22572

    2. NR_024516.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in multiple regions, compared to variant 1. The transcript is a candidate for nonsense-mediated decay (NMD).
      Source sequence(s)
      AK056883, AK300378, BM992563

    3. NR_168388.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041

    4. NR_168389.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041

    5. NR_168390.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041

    6. NR_168391.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041

    7. NR_168392.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041

    8. NR_168393.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041

    9. NR_168394.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      130069894..130144805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      130106007..130180474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06481.2 GenPept UniProtKB/Swiss-Prot:Q06481

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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