TSPAN13 tetraspanin 13 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TSPAN13provided by HGNC
Official Full Name: tetraspanin 13provided by HGNC
Primary source: HGNC:HGNC:21643
See related: Ensembl:ENSG00000106537 MIM:613139; AllianceGenome:HGNC:21643
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NET6; NET-6; TM4SF13
Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
Expression: Broad expression in lung (RPKM 128.5), colon (RPKM 60.3) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7p21.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (16753755..16784536)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (16883444..16914227)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (16793380..16824161)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results suggested that miR-4732-5p may serve as a tumor suppressor in the initiation of breast cancer, but as a tumor promoter in breast cancer progression by targeting TSPAN13.
Title: miR-4732-5p promotes breast cancer progression by targeting TSPAN13.
downregulation of miR-369-3p and consequent upregulation of its target TSPAN13 appear to be involved in pathophysiology of papillary thyroid cancer
Title: Downregulation of TSPAN13 by miR-369-3p inhibits cell proliferation in papillary thyroid cancer (PTC).
The expression of tetraspanins NET-6 and CD151 may indicate an alteration of their biological function during neoplastic transformation.
Title: Expression of tetraspanins NET-6 and CD151 in breast cancer as a potential tumor biomarker.
Knocking down of TSAPN13 in human TERT overexpressing osteosarcoma cells enhanced the apoptosis of the cells. TSPAN13 knockdown in these cells suppressed mesenchymal properties and enhanced epithelial character.
Title: hTERT promotes tumor progression by enhancing TSPAN13 expression in osteosarcoma cells.
The TSPAN13-to-S100A9 ratio was selected to determine the diagnostic value of urinary nucleic acids in prostate cancer (PCa) (P = 0.037) and shown to be significantly higher in PCa than in benign prostatic hyperplasia.
Title: Urinary Nucleic Acid TSPAN13-to-S100A9 Ratio as a Diagnostic Marker in Prostate Cancer.
The expression of PFKFB3, PFKFB4, NAMPT, and TSPAN13 is strongly up-regulated in pediatric glioma.
Title: [EXPRESSION OF PFKFB, HK2, NAMPT, TSPAN13 AND HSPB8 GENES IN PEDIATRIC GLIOMA].
TSPAN13 is overexpressed in prostate cancer and its expression correlates with factors of favourable outcome.
Title: Gene expression profiling reveals overexpression of TSPAN13 in prostate cancer.
tspan13 is overexpressed in prostate cancer and its expression correlates with factors of favourable outcome
Title: Gene expression profiling reveals overexpression of TSPAN13 in prostate cancer.
NET-6 is a potent new breast cancer suppressor gene.
Title: The tetraspanin superfamily member NET-6 is a new tumor suppressor gene.
NET-6 may represent a novel breast cancer suppressor gene.
Title: Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
capsid	gag	The interaction of HIV-1 CA with human cellular tetraspanin 13 protein (TSPAN13) is identified by yeast two-hybrid screen	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH122885 (e-PCR)
- UniSTS:135182

RH103030 (e-PCR)
- UniSTS:97364

D7S2019 (e-PCR)
- UniSTS:3695

RH75359 (e-PCR)
- UniSTS:86151

RH48946 (e-PCR)
- UniSTS:40662

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium channel regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tetraspanin-13

Names: tetraspan NET-6; transmembrane 4 superfamily member 13; transmembrane 4 superfamily member tetraspan NET-6; tspan-13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.