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    ZNF829 zinc finger protein 829 [ Homo sapiens (human) ]

    Gene ID: 374899, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF829provided by HGNC
    Official Full Name
    zinc finger protein 829provided by HGNC
    Primary source
    HGNC:HGNC:34032
    See related
    Ensembl:ENSG00000185869 AllianceGenome:HGNC:34032
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 3.5), ovary (RPKM 1.1) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF829 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36888124..36916291, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39563809..39592026, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37379026..37407193, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC728485 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:37282721-37283221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14534 Neighboring gene ZNF790 antisense RNA 1 Neighboring gene zinc finger protein 790 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14535 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:37368334-37369533 Neighboring gene zinc finger protein 345 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:37382329-37383528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14537 Neighboring gene ribosomal protein L31 pseudogene 61 Neighboring gene zinc finger protein 568 Neighboring gene zinc finger protein 420 Neighboring gene uncharacterized LOC105372390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10553

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
    2. A Y2H-seq approach defines the human protein methyltransferase interactome. Weimann M, et al. Nat Methods, 2013 Apr. PMID 23455924
    3. Phospho-tyrosine dependent protein-protein interaction network. Grossmann A, et al. Mol Syst Biol, 2015 Mar 26. PMID 25814554, Free PMC Article
    4. Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Rowbotham SP, et al. Mol Cell, 2011 May 6. PMID 21549307
    5. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect. Uren PJ, et al. RNA Biol, 2016. PMID 26760575, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ27459, MGC129866, MGC129867, DKFZp779O175, DKFZp686K21248

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 829

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037232.4 → NP_001032309.2  zinc finger protein 829 isoform 2

      See identical proteins and their annotated locations for NP_001032309.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC008733, BC107132, BX538288, DB031896
      Consensus CDS
      CCDS42557.1
      UniProtKB/Swiss-Prot
      A0A075B6T0, Q3KNS6, Q3KNS7, Q6ZNN0, Q7Z657
      Related
      ENSP00000429266.1, ENST00000391711.8
      Conserved Domains (3) summary
      smart00349
      Location:35 → 95
      KRAB; krueppel associated box
      COG5048
      Location:158 → 344
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:214 → 234
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001171979.2 → NP_001165450.1  zinc finger protein 829 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
      Source sequence(s)
      AC008733, BX538288
      Consensus CDS
      CCDS59380.1
      UniProtKB/Swiss-Prot
      Q3KNS6
      Related
      ENSP00000428679.2, ENST00000520965.5
      Conserved Domains (6) summary
      smart00349
      Location:116 → 176
      KRAB; krueppel associated box
      COG5048
      Location:149 → 425
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:295 → 315
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:238 → 259
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:116 → 155
      KRAB; KRAB box
      pfam13465
      Location:335 → 359
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      36888124..36916291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526933.3 → XP_011525235.1  zinc finger protein 829 isoform X1

      See identical proteins and their annotated locations for XP_011525235.1

      UniProtKB/Swiss-Prot
      A0A075B6T0, Q3KNS6, Q3KNS7, Q6ZNN0, Q7Z657
      Conserved Domains (3) summary
      smart00349
      Location:35 → 95
      KRAB; krueppel associated box
      COG5048
      Location:158 → 344
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:214 → 234
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_005258876.4 → XP_005258933.1  zinc finger protein 829 isoform X1

      See identical proteins and their annotated locations for XP_005258933.1

      UniProtKB/Swiss-Prot
      A0A075B6T0, Q3KNS6, Q3KNS7, Q6ZNN0, Q7Z657
      Conserved Domains (3) summary
      smart00349
      Location:35 → 95
      KRAB; krueppel associated box
      COG5048
      Location:158 → 344
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:214 → 234
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      39563809..39592026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320927.1 → XP_054176902.1  zinc finger protein 829 isoform X1

      UniProtKB/Swiss-Prot
      A0A075B6T0, Q3KNS6, Q3KNS7, Q6ZNN0, Q7Z657

    2. XM_054320926.1 → XP_054176901.1  zinc finger protein 829 isoform X1

      UniProtKB/Swiss-Prot
      A0A075B6T0, Q3KNS6, Q3KNS7, Q6ZNN0, Q7Z657
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3KNS6.1 GenPept UniProtKB/Swiss-Prot:Q3KNS6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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