Grm1 glutamate receptor, metabotropic 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grm1provided by MGI
Official Full Name: glutamate receptor, metabotropic 1provided by MGI
Primary source: MGI:MGI:1351338
See related: Ensembl:ENSMUSG00000019828 AllianceGenome:MGI:1351338
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: rcw; wobl; Gprc1a; mGluR1; nmf373; Gm10828; 4930455H15Rik
Summary: Enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration and G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including positive regulation of MAPK cascade; regulation of sensory perception of pain; and synaptic signaling via neuropeptide. Acts upstream of or within L-glutamate import across plasma membrane and cellular response to electrical stimulus. Located in dendrite; nucleus; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including appendicular skeleton; eye; nervous system; testis; and tongue. Used to study autosomal recessive spinocerebellar ataxia 13; skin melanoma; and uveal melanoma. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cerebellum adult (RPKM 17.4), frontal lobe adult (RPKM 5.7) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A1; 10 3.44 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (10561803..10958126, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (10686059..11082382, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of mGluR1-mediated signaling underlying autistic-like core symptoms in Shank1 P1812L-knock-in mice.
Title: Downregulation of mGluR1-mediated signaling underlying autistic-like core symptoms in Shank1 P1812L-knock-in mice.
A vital role for PICK1 in the differential regulation of metabotropic glutamate receptor internalization and synaptic AMPA receptor endocytosis.
Title: A vital role for PICK1 in the differential regulation of metabotropic glutamate receptor internalization and synaptic AMPA receptor endocytosis.
Protein Networks Associated with Native Metabotropic Glutamate 1 Receptors (mGlu1) in the Mouse Cerebellum.
Title: Protein Networks Associated with Native Metabotropic Glutamate 1 Receptors (mGlu(1)) in the Mouse Cerebellum.
Stabilization of Spine Synaptopodin by mGluR1 Is Required for mGluR-LTD.
Title: Stabilization of Spine Synaptopodin by mGluR1 Is Required for mGluR-LTD.
circGrm1 promotes pulmonary artery smooth muscle cell proliferation and migration via suppression of GRM1 expression by FUS.
Title: circ‑Grm1 promotes pulmonary artery smooth muscle cell proliferation and migration via suppression of GRM1 expression by FUS.
Symmetric signal transduction and negative allosteric modulation of heterodimeric mGlu1/5 receptors.
Title: Symmetric signal transduction and negative allosteric modulation of heterodimeric mGlu1/5 receptors.
Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors.
Title: Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors.
Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.
Title: Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.
Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait.
Title: Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait.
Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulators.
Title: Activation of the mGlu(1) metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M(4) muscarinic receptor allosteric modulators.

Submit: New GeneRIF Correction See all GeneRIFs (118)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (4) 1 citation
Endonuclease-mediated (12) 1 citation
Spontaneous (5) 1 citation
Targeted (6) 1 citation
Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Arb40 (e-PCR)
- UniSTS:240137

Grm1 (e-PCR), detects polymorphism
- UniSTS:531470

Grm1 (e-PCR), detects polymorphism
- UniSTS:506953

GRM1 (e-PCR)
- UniSTS:240266

RH126026 (e-PCR)
- UniSTS:162738

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	EXP Inferred from Experiment more info	PubMed
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables PLC activating G protein-coupled glutamate receptor activity	TAS Traceable Author Statement more info	PubMed
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables glutamate receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within L-glutamate import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to electrical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of sensory perception of pain	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic signaling via neuropeptide	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of G protein-coupled receptor dimeric complex	ISO Inferred from Sequence Orthology more info
part_of G protein-coupled receptor homodimeric complex	IEA Inferred from Electronic Annotation more info
part_of G protein-coupled receptor homodimeric complex	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	EXP Inferred from Experiment more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	TAS Traceable Author Statement more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	TAS Traceable Author Statement more info	PubMed
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metabotropic glutamate receptor 1

Names: G protein-coupled receptor, family C, group 1, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114333.3 → NP_001107805.1 metabotropic glutamate receptor 1 isoform beta precursor

See identical proteins and their annotated locations for NP_001107805.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) encodes the shorter isoform (beta). Isoform beta has a different subcellular distribution than isoform alpha and may be functionally distinct due to differential G-protein coupling of its novel C-terminal sequence. Variants 2 and 4 both encode the same isoform (beta).

Source sequence(s)

AC100149, AC155834, AC158641, AC164170

Consensus CDS

CCDS48499.1

UniProtKB/Swiss-Prot

P97772

Related

ENSMUSP00000101190.3, ENSMUST00000105561.9

Conserved Domains (3) summary

cd15449
Location:591 → 840

7tmC_mGluR1; metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:36 → 510

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:521 → 571

NCD3G; Nine Cysteines Domain of family 3 GPCR
NM_001428508.1 → NP_001415437.1 metabotropic glutamate receptor 1 isoform alpha precursor

Status: VALIDATED

Source sequence(s)

AC100149, AC155834, AC158641, AC164170

UniProtKB/Swiss-Prot

P97772, Q6AXG4, Q9EPV6
NM_001428509.1 → NP_001415438.1 metabotropic glutamate receptor 1 isoform beta precursor

Status: VALIDATED

Source sequence(s)

AC100149, AC155834, AC158641, AC164170
NM_016976.4 → NP_058672.1 metabotropic glutamate receptor 1 isoform alpha precursor

See identical proteins and their annotated locations for NP_058672.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (alpha). Variants 1 and 3 both encode the same isoform (alpha).

Source sequence(s)

AC100149, AC155834, AC158641, AC164170

Consensus CDS

CCDS23696.1

UniProtKB/Swiss-Prot

P97772, Q6AXG4, Q9EPV6

Related

ENSMUSP00000037255.7, ENSMUST00000044306.13

Conserved Domains (4) summary

cd15449
Location:591 → 840

7tmC_mGluR1; metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:36 → 510

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:521 → 571

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1150 → 1199

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

10561803..10958126 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155623.1 → XP_036011516.1 metabotropic glutamate receptor 1 isoform X4

Related

ENSMUSP00000101189.2, ENSMUST00000105560.2

Conserved Domains (3) summary

cd15449
Location:591 → 840

7tmC_mGluR1; metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:36 → 510

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:521 → 571

NCD3G; Nine Cysteines Domain of family 3 GPCR
XM_006512549.5 → XP_006512612.1 metabotropic glutamate receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006512612.1

UniProtKB/Swiss-Prot

P97772, Q6AXG4, Q9EPV6

Conserved Domains (4) summary

cd15449
Location:591 → 840

7tmC_mGluR1; metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:36 → 510

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:521 → 571

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1150 → 1199

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
XM_036155622.1 → XP_036011515.1 metabotropic glutamate receptor 1 isoform X1

Conserved Domains (4) summary

cd15449
Location:591 → 840

7tmC_mGluR1; metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:36 → 510

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:521 → 571

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1150 → 1199

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
XM_006512550.4 → XP_006512613.1 metabotropic glutamate receptor 1 isoform X2

Conserved Domains (4) summary

cd15449
Location:351 → 600

7tmC_mGluR1; metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam07562
Location:281 → 331

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:909 → 959

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

cl10011
Location:1 → 270

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_006512554.5 → XP_006512617.1 metabotropic glutamate receptor 1 isoform X5

UniProtKB/TrEMBL

Q3V0U2

Conserved Domains (4) summary

cd15449
Location:182 → 431

7tmC_mGluR1; metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam07562
Location:112 → 162

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:740 → 790

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

cl10011
Location:1 → 101

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_006512551.5 → XP_006512614.1 metabotropic glutamate receptor 1 isoform X3

Conserved Domains (3) summary

cd15449
Location:591 → 840

7tmC_mGluR1; metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam07562
Location:521 → 571

NCD3G; Nine Cysteines Domain of family 3 GPCR

cd06374
Location:36 → 510

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor