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    Kcng3 potassium voltage-gated channel, subfamily G, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 225030, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcng3provided by MGI
    Official Full Name
    potassium voltage-gated channel, subfamily G, member 3provided by MGI
    Primary source
    MGI:MGI:2663923
    See related
    Ensembl:ENSMUSG00000045053 AllianceGenome:MGI:2663923
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KV6.3; Kv10.1a; Kv10.1b
    Summary
    Predicted to enable delayed rectifier potassium channel activity and potassium channel regulator activity. Predicted to be involved in action potential; potassium ion transmembrane transport; and regulation of potassium ion transmembrane transport. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in diencephalon lateral wall mantle layer; hypothalamus mantle layer; lung; and midbrain mantle layer. Orthologous to human KCNG3 (potassium voltage-gated channel modifier subfamily G member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in ovary adult (RPKM 1.2), bladder adult (RPKM 1.1) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kcng3 in Genome Data Viewer
    Location:
    17 E4; 17 53.64 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (83881452..83939595, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (83574023..83631995, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2501 Neighboring gene predicted gene, 41635 Neighboring gene predicted gene, 34801 Neighboring gene STARR-positive B cell enhancer ABC_E9967 Neighboring gene STARR-seq mESC enhancer starr_43388 Neighboring gene STARR-seq mESC enhancer starr_43389 Neighboring gene STARR-seq mESC enhancer starr_43390 Neighboring gene STARR-seq mESC enhancer starr_43391 Neighboring gene STARR-seq mESC enhancer starr_43393 Neighboring gene metastasis associated 3 Neighboring gene predicted gene, 46597 Neighboring gene STARR-seq mESC enhancer starr_43408 Neighboring gene predicted gene, 41637

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. De novo expression of Kv6.3 contributes to changes in vascular smooth muscle cell excitability in a hypertensive mice strain. Moreno-Domínguez A, et al. J Physiol, 2009 Feb 1. PMID 19074965, Free PMC Article
    2. Modification of Kv2.1 K+ currents by the silent Kv10 subunits. Vega-Saenz de Miera EC. Brain Res Mol Brain Res, 2004 Apr 7. PMID 15046870
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables potassium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    voltage-gated potassium channel regulatory subunit KCNG3; potassium voltage-gated channel subfamily G member 3
    Names
    voltage-gated potassium channel subunit Kv10.1
    voltage-gated potassium channel subunit Kv6.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153512.1 → NP_705732.1  voltage-gated potassium channel regulatory subunit KCNG3

      See identical proteins and their annotated locations for NP_705732.1

      Status: PROVISIONAL

      Source sequence(s)
      AF454552
      Consensus CDS
      CCDS28996.1
      UniProtKB/Swiss-Prot
      P59053
      Related
      ENSMUSP00000054910.2, ENSMUST00000051482.2
      Conserved Domains (4) summary
      smart00225
      Location:11 → 119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:216 → 417
      Ion_trans; Ion transport protein
      pfam07885
      Location:360 → 405
      Ion_trans_2; Ion channel
      cl02518
      Location:11 → 111
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      83881452..83939595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524200.5 → XP_006524263.1  potassium voltage-gated channel subfamily G member 3 isoform X1

      See identical proteins and their annotated locations for XP_006524263.1

      UniProtKB/Swiss-Prot
      P59053
      Related
      ENSMUSP00000157121.2, ENSMUST00000234613.2
      Conserved Domains (2) summary
      cd18422
      Location:11 → 122
      BTB_POZ_KCNG3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 3 (KCNG3)
      pfam00520
      Location:202 → 406
      Ion_trans; Ion transport protein

    2. XM_036160577.1 → XP_036016470.1  potassium voltage-gated channel subfamily G member 3 isoform X2

      Conserved Domains (1) summary
      cl38908
      Location:11 → 122
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    RNA

    1. XR_004939523.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59053.1 GenPept UniProtKB/Swiss-Prot:P59053

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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