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    Zfp950 zinc finger protein 950 [ Mus musculus (house mouse) ]

    Gene ID: 414758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp950provided by MGI
    Official Full Name
    zinc finger protein 950provided by MGI
    Primary source
    MGI:MGI:2652824
    See related
    Ensembl:ENSMUSG00000074733 AllianceGenome:MGI:2652824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp826; mszf84; Gm34518; 5830428H23Rik
    Summary
    Predicted to enable DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and protein-macromolecule adaptor activity. Acts upstream of or within several processes, including face morphogenesis; smooth muscle cell migration; and vasculogenesis. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in bladder; central nervous system; testis; and ureter. Orthologous to several human genes including ZNF234 (zinc finger protein 234); ZNF254 (zinc finger protein 254); and ZNF28 (zinc finger protein 28). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 3.3), limb E14.5 (RPKM 2.9) and 26 other tissues See more
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    Genomic context

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    See Zfp950 in Genome Data Viewer
    Location:
    19 D3; 19 56.67 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (61042692..61129297, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (61053840..61140844, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene predicted gene 9529 Neighboring gene predicted gene, 22520 Neighboring gene STARR-positive B cell enhancer ABC_E10001 Neighboring gene STARR-positive B cell enhancer ABC_E9458 Neighboring gene STARR-positive B cell enhancer ABC_E7681 Neighboring gene STARR-positive B cell enhancer ABC_E1214 Neighboring gene STARR-seq mESC enhancer starr_46603 Neighboring gene STARR-seq mESC enhancer starr_46604 Neighboring gene ribosomal protein S25 pseudogene Neighboring gene predicted gene 6020 Neighboring gene predicted gene, 22365 Neighboring gene mortality factor 4 like 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PDGF signaling specificity is mediated through multiple immediate early genes. Schmahl J, et al. Nat Genet, 2007 Jan. PMID 17143286
    2. Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Suzuki A, et al. Mech Dev, 2018 Apr. PMID 29475039, Free PMC Article
    3. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within excretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within face morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within roof of mouth development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within smooth muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 950
    Names
    zinc finger protein 826
    zinc finger prtoein 950

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001737.3 → NP_001001737.1  zinc finger protein 950 isoform c

      See identical proteins and their annotated locations for NP_001001737.1

      Status: VALIDATED

      Source sequence(s)
      AC165327
      Consensus CDS
      CCDS84461.1
      UniProtKB/TrEMBL
      A0A0U1RPH0, Q8BL88
      Related
      ENSMUSP00000145915.2, ENSMUST00000143264.8
      Conserved Domains (2) summary
      smart00349
      Location:4 → 45
      KRAB; krueppel associated box
      pfam01352
      Location:4 → 43
      KRAB; KRAB box

    2. NM_001309195.2 → NP_001296124.1  zinc finger protein 950 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC165327
      Consensus CDS
      CCDS84462.1
      UniProtKB/TrEMBL
      A0A0U1RP12, A0A0U1RPH0
      Related
      ENSMUSP00000145786.2, ENSMUST00000205854.2
      Conserved Domains (2) summary
      smart00349
      Location:4 → 45
      KRAB; krueppel associated box
      pfam01352
      Location:4 → 43
      KRAB; KRAB box

    3. NM_001309216.2 → NP_001296145.1  zinc finger protein 950 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC165327
      Consensus CDS
      CCDS84463.1
      UniProtKB/TrEMBL
      A0A0U1RQ46
      Related
      ENSMUSP00000146243.2, ENSMUST00000180544.3
      Conserved Domains (3) summary
      COG5048
      Location:101 → 514
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:133 → 153
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 44
      KRAB; KRAB box

    4. NM_001409028.1 → NP_001395957.1  zinc finger protein 950 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC161413, AC165327
      UniProtKB/TrEMBL
      A0A0U1RPH0

    RNA

    1. NR_131953.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC161413, AC165327

    2. NR_131954.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC165327
      Related
      ENSMUST00000127290.8

    3. NR_131955.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC165327

    4. NR_131956.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC165327

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      61042692..61129297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161622.1 → XP_036017515.1  zinc finger protein 950 isoform X3

      UniProtKB/TrEMBL
      A0A0U1RNP3
      Related
      ENSMUSP00000145648.2, ENSMUST00000205712.2
      Conserved Domains (2) summary
      sd00017
      Location:77 → 97
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 44
      KRAB; KRAB box

    2. XM_036161621.1 → XP_036017514.1  zinc finger protein 950 isoform X1

      UniProtKB/TrEMBL
      A0A0U1RQ46
      Conserved Domains (3) summary
      COG5048
      Location:101 → 514
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:133 → 153
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 44
      KRAB; KRAB box

    3. XM_017318246.3 → XP_017173735.1  zinc finger protein 950 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:57 → 470
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:89 → 109
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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