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    Plch2 phospholipase C, eta 2 [ Mus musculus (house mouse) ]

    Gene ID: 269615, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plch2provided by MGI
    Official Full Name
    phospholipase C, eta 2provided by MGI
    Primary source
    MGI:MGI:2443078
    See related
    Ensembl:ENSMUSG00000029055 AllianceGenome:MGI:2443078
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Plcl4; PLCeta2; Plc-eta2; A930027K05Rik
    Summary
    Enables phospholipase C activity. Acts upstream of or within phosphatidylinositol metabolic process. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; integumental system; lower urinary tract; and sensory organ. Orthologous to human PLCH2 (phospholipase C eta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 24.6), colon adult (RPKM 15.7) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plch2 in Genome Data Viewer
    Location:
    4 E2; 4 86.13 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155067572..155148548, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (154983115..155064091, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8040 Neighboring gene hes family bHLH transcription factor 5 Neighboring gene pantothenate kinase 4 Neighboring gene STARR-positive B cell enhancer ABC_E10295 Neighboring gene peroxisomal biogenesis factor 10 Neighboring gene STARR-positive B cell enhancer ABC_E1295 Neighboring gene retention in endoplasmic reticulum sorting receptor 1 Neighboring gene MORN repeat containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phospholipase C-η2 is required for retinoic acid-stimulated neurite growth. Popovics P, et al. J Neurochem, 2013 Mar. PMID 23237262
    2. Phospholipase C-eta2 is highly expressed in the habenula and retina. Kanemaru K, et al. Gene Expr Patterns, 2010 Feb-Mar. PMID 20060933
    3. Molecular cloning and characterization of PLC-eta2. Zhou Y, et al. Biochem J, 2005 Nov 1. PMID 16107206, Free PMC Article
    4. Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes. Stewart AJ, et al. Int J Mol Med, 2005 Jan. PMID 15583837
    5. A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme. Nakahara M, et al. J Biol Chem, 2005 Aug 12. PMID 15899900

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of PLCeta2 in neuritogenesis was assessed during retinoic acid (RA)-induced Neuro2A cell differentiation
      Title: Phospholipase C-η2 is required for retinoic acid-stimulated neurite growth.
    2. PLCeta2 exhibited a dynamic expression pattern during postnatal retinal development, strongly suggesting that this isozyme might be involved in the development and maturation of the retina.
      Title: Phospholipase C-eta2 is highly expressed in the habenula and retina.
    3. PLC(eta)2 is a neuron-specific isozyme that may be important for the formation and/or maintenance of the neuronal network in the postnatal brain
      Title: A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme.
    4. The molecular cloning and sequencing of phospholipase C eta2 are reported.
      Title: Molecular cloning and characterization of PLC-eta2.
    5. molecular cloning of PLC-eta1 and PLC-eta2.
      Title: Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol phospholipase C activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
    Names
    phosphoinositide phospholipase C-eta-2
    phosphoinositide phospholipase C-like 4
    phospholipase C-like protein 4
    NP_001106831.1
    NP_001343399.1
    NP_780765.2
    XP_006538999.1
    XP_006539003.1
    XP_011248570.1
    XP_011248571.1
    XP_011248572.1
    XP_011248573.1
    XP_011248574.1
    XP_011248575.1
    XP_011248576.1
    XP_011248577.1
    XP_011248578.1
    XP_017175736.1
    XP_036020059.1
    XP_036020060.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113360.3 → NP_001106831.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform b

      See identical proteins and their annotated locations for NP_001106831.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (b).
      Source sequence(s)
      AL831788, BX004788
      Consensus CDS
      CCDS71533.1
      UniProtKB/Swiss-Prot
      A2AP18, A6PWW5, Q3LUA7, Q4QSC7, Q80WP6, Q8BJV1, Q8BWU4, Q8BXN5, Q8CFR1
      UniProtKB/TrEMBL
      H3BK11
      Related
      ENSMUSP00000101256.3, ENSMUST00000105631.9
      Conserved Domains (8) summary
      cd00275
      Location:838 → 963
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08633
      Location:399 → 808
      PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
      PLN02952
      Location:316 → 948
      PLN02952; phosphoinositide phospholipase C
      cd00051
      Location:247 → 313
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd13364
      Location:123 → 229
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      pfam00169
      Location:141 → 229
      PH; PH domain
      pfam09279
      Location:317 → 399
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:248 → 309
      EF-hand_7; EF-hand domain pair

    2. NM_001356470.1 → NP_001343399.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AK044619, AL831788, BC052329, BC060083, BX004788, CJ113070, DQ176851
      UniProtKB/TrEMBL
      H3BIW6
      Related
      ENSMUSP00000134750.2, ENSMUST00000176194.8
      Conserved Domains (6) summary
      cd08633
      Location:318 → 727
      PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
      cd13364
      Location:22 → 128
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:146 → 175
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl26464
      Location:916 → 1092
      Atrophin-1; Atrophin-1 family
      cl27705
      Location:288 → 867
      PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
      cl28895
      Location:146 → 306
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

    3. NM_175556.5 → NP_780765.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform a

      See identical proteins and their annotated locations for NP_780765.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate splice site and contains an alternate exon in the 3' coding region, resulting in an early stop codon, compared to variant 1. It encodes isoform a, which is shorter and has a distinct C-terminus, compared to isoform b.
      Source sequence(s)
      AL831788, BX004788
      Consensus CDS
      CCDS38990.2
      UniProtKB/TrEMBL
      F7C3A0, F8VQ50, H3BIW6
      Related
      ENSMUSP00000122704.3, ENSMUST00000139976.9
      Conserved Domains (8) summary
      cd00275
      Location:838 → 963
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08633
      Location:399 → 808
      PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
      PLN02952
      Location:316 → 948
      PLN02952; phosphoinositide phospholipase C
      cd00051
      Location:247 → 313
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd13364
      Location:123 → 229
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      pfam00169
      Location:141 → 229
      PH; PH domain
      pfam09279
      Location:317 → 399
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:248 → 309
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155067572..155148548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250270.1 → XP_011248572.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X4

      See identical proteins and their annotated locations for XP_011248572.1

      Conserved Domains (6) summary
      cd08633
      Location:336 → 745
      PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
      PLN02228
      Location:306 → 885
      PLN02228; Phosphoinositide phospholipase C
      PHA03247
      Location:934 → 1426
      PHA03247; large tegument protein UL36; Provisional
      cd13364
      Location:40 → 146
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:164 → 193
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:164 → 324
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

    2. XM_011250271.4 → XP_011248573.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X4

      See identical proteins and their annotated locations for XP_011248573.1

      Conserved Domains (6) summary
      cd08633
      Location:336 → 745
      PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
      PLN02228
      Location:306 → 885
      PLN02228; Phosphoinositide phospholipase C
      PHA03247
      Location:934 → 1426
      PHA03247; large tegument protein UL36; Provisional
      cd13364
      Location:40 → 146
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:164 → 193
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:164 → 324
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

    3. XM_006538940.2 → XP_006539003.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X7

      Related
      ENSMUSP00000118292.3, ENSMUST00000135665.9
      Conserved Domains (5) summary
      cd08633
      Location:469 → 878
      PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
      PLN02228
      Location:391 → 1018
      PLN02228; Phosphoinositide phospholipase C
      PHA03247
      Location:1065 → 1391
      PHA03247; large tegument protein UL36; Provisional
      cd13364
      Location:193 → 299
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd16221
      Location:317 → 457
      EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)

    4. XM_036164167.1 → XP_036020060.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X12

      UniProtKB/TrEMBL
      H3BIW6
      Conserved Domains (4) summary
      cd08633
      Location:469 → 878
      PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
      PLN02228
      Location:391 → 1018
      PLN02228; Phosphoinositide phospholipase C
      cd13364
      Location:193 → 299
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd16221
      Location:317 → 457
      EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)

    5. XM_006538936.2 → XP_006538999.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X2

      Conserved Domains (5) summary
      cd08633
      Location:469 → 878
      PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
      PLN02228
      Location:391 → 1018
      PLN02228; Phosphoinositide phospholipase C
      PHA03247
      Location:1067 → 1559
      PHA03247; large tegument protein UL36; Provisional
      cd13364
      Location:193 → 299
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd16221
      Location:317 → 457
      EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)

    6. XM_017320247.1 → XP_017175736.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X9

      UniProtKB/TrEMBL
      H3BIW6
      Conserved Domains (5) summary
      cd08633
      Location:469 → 878
      PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
      PLN02228
      Location:391 → 1018
      PLN02228; Phosphoinositide phospholipase C
      PHA03247
      Location:1067 → 1243
      PHA03247; large tegument protein UL36; Provisional
      cd13364
      Location:193 → 299
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd16221
      Location:317 → 457
      EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)

    7. XM_011250272.1 → XP_011248574.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X5

      Conserved Domains (6) summary
      cd08633
      Location:489 → 898
      PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
      PLN02228
      Location:459 → 1038
      PLN02228; Phosphoinositide phospholipase C
      PHA03247
      Location:1085 → 1411
      PHA03247; large tegument protein UL36; Provisional
      cd13364
      Location:193 → 299
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:317 → 346
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:317 → 477
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

    8. XM_011250276.2 → XP_011248578.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X11

      UniProtKB/TrEMBL
      H3BIW6
      Conserved Domains (5) summary
      cd08633
      Location:489 → 898
      PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
      PLN02228
      Location:459 → 1038
      PLN02228; Phosphoinositide phospholipase C
      cd13364
      Location:193 → 299
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:317 → 346
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:317 → 477
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

    9. XM_036164166.1 → XP_036020059.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X11

      UniProtKB/TrEMBL
      H3BIW6
      Conserved Domains (5) summary
      cd08633
      Location:489 → 898
      PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
      PLN02228
      Location:459 → 1038
      PLN02228; Phosphoinositide phospholipase C
      cd13364
      Location:193 → 299
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:317 → 346
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:317 → 477
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

    10. XM_011250268.1 → XP_011248570.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X1

      Conserved Domains (6) summary
      cd08633
      Location:489 → 898
      PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
      PLN02228
      Location:459 → 1038
      PLN02228; Phosphoinositide phospholipase C
      PHA03247
      Location:1087 → 1579
      PHA03247; large tegument protein UL36; Provisional
      cd13364
      Location:193 → 299
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:317 → 346
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:317 → 477
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

    11. XM_011250274.2 → XP_011248576.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X8

      UniProtKB/TrEMBL
      H3BIW6
      Conserved Domains (6) summary
      cd08633
      Location:489 → 898
      PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
      PLN02228
      Location:459 → 1038
      PLN02228; Phosphoinositide phospholipase C
      PHA03247
      Location:1087 → 1263
      PHA03247; large tegument protein UL36; Provisional
      cd13364
      Location:193 → 299
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:317 → 346
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:317 → 477
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

    12. XM_011250269.2 → XP_011248571.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X3

      Conserved Domains (6) summary
      cd08633
      Location:341 → 750
      PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
      PLN02228
      Location:311 → 890
      PLN02228; Phosphoinositide phospholipase C
      PHA03247
      Location:939 → 1431
      PHA03247; large tegument protein UL36; Provisional
      cd13364
      Location:45 → 151
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:169 → 198
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:169 → 329
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

    13. XM_011250273.3 → XP_011248575.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X6

      Conserved Domains (6) summary
      cd08633
      Location:318 → 727
      PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
      PLN02228
      Location:288 → 867
      PLN02228; Phosphoinositide phospholipase C
      PHA03247
      Location:916 → 1408
      PHA03247; large tegument protein UL36; Provisional
      cd13364
      Location:22 → 128
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:146 → 175
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:146 → 306
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

    14. XM_011250275.2 → XP_011248577.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X10

      Conserved Domains (5) summary
      cd08633
      Location:489 → 898
      PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
      PLN02228
      Location:459 → 1038
      PLN02228; Phosphoinositide phospholipase C
      cd13364
      Location:193 → 299
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:317 → 346
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:317 → 477
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

    RNA

    1. XR_004941911.1 RNA Sequence

    2. XR_004941914.1 RNA Sequence

    3. XR_004941913.1 RNA Sequence

    4. XR_001784150.1 RNA Sequence

    5. XR_004941912.1 RNA Sequence

    6. XR_881430.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AP18.2 GenPept UniProtKB/Swiss-Prot:A2AP18

    Gene LinkOut

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