Usp26 ubiquitin specific peptidase 26 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp26provided by MGI
Official Full Name: ubiquitin specific peptidase 26provided by MGI
Primary source: MGI:MGI:1933247
See related: Ensembl:ENSMUSG00000055780 AllianceGenome:MGI:1933247
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable K48-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm and sperm flagellum. Predicted to be active in cytosol and nucleus. Is expressed in testis. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 6. Orthologous to human USP26 (ubiquitin specific peptidase 26). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: X A5; X 28.31 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (50841544..50890110, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (51752667..51801233, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USP26 as a hepatitis B virus-induced deubiquitinase primes hepatocellular carcinogenesis by epigenetic remodeling.
Title: USP26 as a hepatitis B virus-induced deubiquitinase primes hepatocellular carcinogenesis by epigenetic remodeling.
An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations.
Title: An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations.
The osteoprotective role of USP26 in coordinating bone formation and resorption.
Title: The osteoprotective role of USP26 in coordinating bone formation and resorption.
Ubiquitin-Specific Protease 29 Exacerbates Cerebral Ischemia-Reperfusion Injury in Mice.
Title: Ubiquitin-Specific Protease 29 Exacerbates Cerebral Ischemia-Reperfusion Injury in Mice.
Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans.
Title: Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans.
Usp26 mutation in mice leads to defective spermatogenesis depending on genetic background.
Title: Usp26 mutation in mice leads to defective spermatogenesis depending on genetic background.
Germ-cell-specific sex-linked genes, like Usp26, are subject to meiotic sex-chromosome inactivation (MSCI) during spermatogenesis.
Title: Differential expression of sex-linked and autosomal germ-cell-specific genes during spermatogenesis in the mouse.
Usp26 is a testis-specific gene identified in a genome-wide cDNA subtraction screen.
Title: An abundance of X-linked genes expressed in spermatogonia.
The loss of Usp26 affects spermatogenesis and hormone secretion and causes male subfertility. This study also provides the evidence on the interactions between USP26 and androgen receptor in mouse testis, whereby pointing to a potential mechanism.
Title: Disruption of ubiquitin specific protease 26 gene causes male subfertility associated with spermatogenesis defects in mice†.
RT-PCR assays detected the expression of Usp26 in germ cells, but not in primary Sertoli cell lines
Title: Localization of ubiquitin specific protease 26 at blood-testis barrier and near Sertoli cell-germ cell interface in mouse testes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables K48-linked deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables K48-linked deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables deubiquitinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of androgen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 26

Names: deubiquitinating enzyme 26; ubiquitin specific protease 26; ubiquitin thioesterase 26; ubiquitin thiolesterase 26; ubiquitin-specific-processing protease 26

NP_113565.2

EC 3.4.19.12

XP_017174134.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031388.2 → NP_113565.2 ubiquitin carboxyl-terminal hydrolase 26

See identical proteins and their annotated locations for NP_113565.2

Status: VALIDATED

Source sequence(s)

AK133417, AL662931

Consensus CDS

CCDS30122.1

UniProtKB/Swiss-Prot

Q05A11, Q99MX1

Related

ENSMUSP00000110519.2, ENSMUST00000114869.8

Conserved Domains (3) summary

cd02257
Location:747 → 814

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:287 → 553

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 104

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

50841544..50890110 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318645.1 → XP_017174134.1 ubiquitin carboxyl-terminal hydrolase 26 isoform X1

UniProtKB/Swiss-Prot

Q05A11, Q99MX1

Related

ENSMUSP00000069140.4, ENSMUST00000069509.4

Conserved Domains (3) summary

cd02257
Location:747 → 814

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:287 → 553

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 104

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37