Mtarc2 mitochondrial amidoxime reducing component 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mtarc2provided by RGD
Official Full Name: mitochondrial amidoxime reducing component 2provided by RGD
Primary source: RGD:621257
See related: EnsemblRapid:ENSRNOG00000077900 AllianceGenome:RGD:621257
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mg87; Marc2; Mosc2; mARC1
Summary: Predicted to enable molybdenum ion binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on other nitrogenous compounds as donors. Predicted to be involved in cellular detoxification of nitrogen compound; nitrate metabolic process; and nitric oxide biosynthetic process. Predicted to be located in mitochondrion. Orthologous to human MTARC2 (mitochondrial amidoxime reducing component 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 888.5), Kidney (RPKM 596.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q26

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (98894347..98928754, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (96362810..96397284, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (102724266..102755511, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The presence of a novel reductive enzyme system of importance for lipid synthesis that is exclusively localized to the outer mitochondrial membrane and is composed of CYB5B, MOSC2, and a third unknown component (a CYB5B reductase).
Title: Amidoxime reductase system containing cytochrome b5 type B (CYB5B) and MOSC2 is of importance for lipid synthesis in adipocyte mitochondria.

Submit: New GeneRIF Correction

General gene information

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Markers

AU048082 (e-PCR)
- UniSTS:109890

AU024851 (e-PCR)
- UniSTS:115840

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables molybdenum ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables molybdenum ion binding	ISO Inferred from Sequence Orthology more info
enables molybdopterin cofactor binding	IBA Inferred from Biological aspect of Ancestor more info
enables molybdopterin cofactor binding	ISO Inferred from Sequence Orthology more info
enables nitrate reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nitrate reductase activity	ISO Inferred from Sequence Orthology more info
enables nitrite reductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on other nitrogenous compounds as donors	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular detoxification of nitrogen compound	ISO Inferred from Sequence Orthology more info
involved_in nitrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nitrate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitochondrial amidoxime reducing component 2

Names: MOCO sulphurase C-terminal domain containing 2; MOSC domain-containing protein 2, mitochondrial; moco sulfurase C-terminal domain-containing protein 2; molybdenum cofactor sulfurase C-terminal domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433851.1 → NP_001420780.1 mitochondrial amidoxime reducing component 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013
NM_134410.3 → NP_599237.2 mitochondrial amidoxime reducing component 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

Related

ENSRNOP00000104954.1, ENSRNOT00000149208.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

98894347..98928754 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017598658.3 → XP_017454147.1 mitochondrial amidoxime reducing component 2 isoform X1

UniProtKB/TrEMBL

A6JGP7

Conserved Domains (3) summary

COG3217
Location:56 → 333

YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]

pfam03473
Location:202 → 334

MOSC; MOSC domain

pfam03476
Location:54 → 175

MOSC_N; MOSC N-terminal beta barrel domain