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    Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64156, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Uba52provided by RGD
    Official Full Name
    ubiquitin A-52 residue ribosomal protein fusion product 1provided by RGD
    Primary source
    RGD:68344
    See related
    EnsemblRapid:ENSRNOG00000090524 AllianceGenome:RGD:68344
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ubb; Rps27a
    Summary
    Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Involved in response to insecticide. Part of cytosolic large ribosomal subunit. Orthologous to human UBA52 (ubiquitin A-52 residue ribosomal protein fusion product 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 2356.7), Heart (RPKM 2317.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uba52 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18952583..18954780)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18918614..18920807)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20668925..20671127)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene elongation factor for RNA polymerase II Neighboring gene FKBP prolyl isomerase 8 Neighboring gene KxDL motif containing 1 Neighboring gene required for excision 1-B domain containing Neighboring gene cytokine receptor-like factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin fusion proteins are overexpressed in colon cancer but not in gastric cancer. Barnard GF, et al. Biochim Biophys Acta, 1995 Dec 12. PMID 8541345
    2. The cDNA for the ubiquitin-52-amino-acid fusion protein from rat encodes a previously unidentified 60 S ribosomal subunit protein. Redman KL, et al. Biochem J, 1996 Apr 1. PMID 8670124, Free PMC Article
    3. Ubiquitin and ubiquitin-conjugated protein expression in the rat cerebral cortex and hippocampus following traumatic brain injury (TBI). Yao X, et al. Brain Res, 2007 Nov 28. PMID 17936732
    4. The carboxyl extensions of two rat ubiquitin fusion proteins are ribosomal proteins S27a and L40. Chan YL, et al. Biochem Biophys Res Commun, 1995 Oct 13. PMID 7488009
    5. Post-translational processing of rat ribosomal proteins. Ubiquitous methylation of Lys22 within the zinc-finger motif of RL40 (carboxy-terminal extension protein 52) and tissue-specific methylation of Lys4 in RL29. Williamson NA, et al. Eur J Biochem, 1997 Jun 15. PMID 9219540

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UBA52 Attunes VDAC1-Mediated Mitochondrial Dysfunction and Dopaminergic Neuronal Death.
      Title: UBA52 Attunes VDAC1-Mediated Mitochondrial Dysfunction and Dopaminergic Neuronal Death.
    2. Males and females differ in the regulation and engagement of, but not requirement for, protein degradation in the amygdala during fear memory formation.
      Title: Males and females differ in the regulation and engagement of, but not requirement for, protein degradation in the amygdala during fear memory formation.
    3. Uba52 protein was restrictedly localized within the surface of the marginal cells of the stria vascularis of cochlea.
      Title: The localization of proteins encoded by CRYM, KIAA1199, UBA52, COL9A3, and COL9A1, genes highly expressed in the cochlea.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to insecticide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of rough endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-ribosomal protein eL40 fusion protein
    Names
    60S ribosomal protein L40
    CEP52
    ubiquitin-60S ribosomal protein L40

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031687.3 → NP_113875.1  ubiquitin-ribosomal protein eL40 fusion protein

      See identical proteins and their annotated locations for NP_113875.1

      Status: VALIDATED

      Source sequence(s)
      BC061544, BP480615, BP492585
      UniProtKB/Swiss-Prot
      P62986, P62989, Q63446
      UniProtKB/TrEMBL
      Q6P7R7
      Conserved Domains (2) summary
      cd01803
      Location:1 → 76
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01020
      Location:79 → 126
      Ribosomal_L40e; Ribosomal L40e family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      18952583..18954780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275684.1 → XP_063131754.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X2

    2. XM_008771146.4 → XP_008769368.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X3

      See identical proteins and their annotated locations for XP_008769368.1

      UniProtKB/Swiss-Prot
      P62986, P62989, Q63446
      UniProtKB/TrEMBL
      Q6P7R7
      Conserved Domains (2) summary
      cd01803
      Location:1 → 76
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01020
      Location:79 → 126
      Ribosomal_L40e; Ribosomal L40e family

    3. XM_039094805.2 → XP_038950733.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X1

      Related
      ENSRNOP00000027073.4, ENSRNOT00000027073.8
      Conserved Domains (2) summary
      cd01803
      Location:42 → 117
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01020
      Location:120 → 167
      Ribosomal_L40e; Ribosomal L40e family

    4. XM_006252935.2 → XP_006252997.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X3

      See identical proteins and their annotated locations for XP_006252997.1

      UniProtKB/Swiss-Prot
      P62986, P62989, Q63446
      UniProtKB/TrEMBL
      Q6P7R7
      Conserved Domains (2) summary
      cd01803
      Location:1 → 76
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01020
      Location:79 → 126
      Ribosomal_L40e; Ribosomal L40e family

    5. XM_063275685.1 → XP_063131755.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X3

      UniProtKB/Swiss-Prot
      P62986, P62989, Q63446
      UniProtKB/TrEMBL
      Q6P7R7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62986.2 GenPept UniProtKB/Swiss-Prot:P62986

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