Myrf myelin regulatory factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myrfprovided by RGD
Official Full Name: myelin regulatory factorprovided by RGD
Primary source: RGD:1306622
See related: EnsemblRapid:ENSRNOG00000028274 AllianceGenome:RGD:1306622
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mrf; RGD1306622
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in positive regulation of oligodendrocyte differentiation; response to cocaine; and response to immobilization stress. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in endoplasmic reticulum membrane and nucleus. Human ortholog(s) of this gene implicated in cerebral infarction; congenital diaphragmatic hernia; hyperopia; nanophthalmos; and primary angle-closure glaucoma. Orthologous to human MYRF (myelin regulatory factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 49.8), Lung (RPKM 39.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (216279057..216311155, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (206854175..206886276, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (226260558..226292650, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D1M19Mit115 (e-PCR)
- UniSTS:128329

D19Mit115 (e-PCR), detects polymorphism
- UniSTS:128329

BF400268 (e-PCR)
- UniSTS:244906

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in central nervous system myelin maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system myelin maintenance	ISO Inferred from Sequence Orthology more info
involved_in central nervous system myelination	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte development	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oligodendrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autoprocessing	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoprocessing	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myelin regulatory factor

Names: myelin gene regulatory factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170487.1 → NP_001163958.1 myelin regulatory factor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6ACZ2, D4A352

Conserved Domains (5) summary

pfam05224
Location:392 → 539

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13884
Location:586 → 646

Peptidase_S74; Chaperone of endosialidase

pfam13887
Location:666 → 701

MRF_C1; Myelin gene regulatory factor -C-terminal domain 1

pfam13888
Location:1007 → 1138

MRF_C2; Myelin gene regulatory factor C-terminal domain 2

cl01455
Location:278 → 331

PhnH; Bacterial phosphonate metabolizm protein (PhnH)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

216279057..216311155 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231030.5 → XP_006231092.1 myelin regulatory factor isoform X1

UniProtKB/TrEMBL

A0A8I6ACZ2

Related

ENSRNOP00000035676.6, ENSRNOT00000039133.7

Conserved Domains (5) summary

pfam05224
Location:392 → 539

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13884
Location:586 → 646

Peptidase_S74; Chaperone of endosialidase

pfam13887
Location:666 → 701

MRF_C1; Myelin gene regulatory factor -C-terminal domain 1

pfam13888
Location:1006 → 1137

MRF_C2; Myelin gene regulatory factor C-terminal domain 2

cl01455
Location:278 → 331

PhnH; Bacterial phosphonate metabolizm protein (PhnH)
XM_063286961.1 → XP_063143031.1 myelin regulatory factor isoform X5
XM_008760221.3 → XP_008758443.1 myelin regulatory factor isoform X4

UniProtKB/TrEMBL

A0A8I6ARG5

Related

ENSRNOP00000092057.2, ENSRNOT00000114113.2

Conserved Domains (5) summary

pfam05224
Location:304 → 451

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13884
Location:498 → 558

Peptidase_S74; Chaperone of endosialidase

pfam13887
Location:578 → 613

MRF_C1; Myelin gene regulatory factor -C-terminal domain 1

pfam13888
Location:919 → 1050

MRF_C2; Myelin gene regulatory factor C-terminal domain 2

cl01455
Location:190 → 243

PhnH; Bacterial phosphonate metabolizm protein (PhnH)
XM_008760220.3 → XP_008758442.1 myelin regulatory factor isoform X3

UniProtKB/TrEMBL

A0A8I6ACZ2

Conserved Domains (6) summary

TIGR02600
Location:768 → 866

Verru_Chthon_A; Verru_Chthon cassette protein A

pfam05224
Location:392 → 539

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13884
Location:586 → 646

Peptidase_S74; Chaperone of endosialidase

pfam13887
Location:666 → 701

MRF_C1; Myelin gene regulatory factor -C-terminal domain 1

pfam13888
Location:979 → 1110

MRF_C2; Myelin gene regulatory factor C-terminal domain 2

cl01455
Location:278 → 331

PhnH; Bacterial phosphonate metabolizm protein (PhnH)
XM_006231031.4 → XP_006231093.1 myelin regulatory factor isoform X2

UniProtKB/TrEMBL

A0A8I6ACZ2, A0A8I6AIU7

Related

ENSRNOP00000095013.1, ENSRNOT00000094966.2

Conserved Domains (6) summary

TIGR02600
Location:768 → 867

Verru_Chthon_A; Verru_Chthon cassette protein A

pfam05224
Location:392 → 539

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13884
Location:586 → 646

Peptidase_S74; Chaperone of endosialidase

pfam13887
Location:666 → 701

MRF_C1; Myelin gene regulatory factor -C-terminal domain 1

pfam13888
Location:980 → 1111

MRF_C2; Myelin gene regulatory factor C-terminal domain 2

cl01455
Location:278 → 331

PhnH; Bacterial phosphonate metabolizm protein (PhnH)