Amd1 adenosylmethionine decarboxylase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Amd1provided by RGD
Official Full Name: adenosylmethionine decarboxylase 1provided by RGD
Primary source: RGD:2104
See related: EnsemblRapid:ENSRNOG00000000585 AllianceGenome:RGD:2104
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Amd1a; Amd1b
Summary: Enables adenosylmethionine decarboxylase activity and putrescine binding activity. Involved in S-adenosylmethionine metabolic process; spermidine biosynthetic process; and spermine biosynthetic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human AMD1 (adenosylmethionine decarboxylase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 374.7), Kidney (RPKM 362.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (45250289..45324939, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (43695783..43711476, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (45384000..45399694, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Amd1 (e-PCR), detects polymorphism
- UniSTS:531466

GDB:192496 (e-PCR)
- UniSTS:99316

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables adenosylmethionine decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenosylmethionine decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenosylmethionine decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables putrescine binding	IBA Inferred from Biological aspect of Ancestor more info
enables putrescine binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in S-adenosylmethionine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in polyamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in spermidine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermidine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in spermidine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in spermidine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in spermine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in spermine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: S-adenosylmethionine decarboxylase proenzyme

Names: S-Adenosylmethionine decarboxylase 1B; S-adenosylmethionine decarboxylase 1; S-adenosylmethionine decarboxylase 1A; SAMDC; adoMetDC

NP_112273.3

EC 4.1.1.50

XP_063135627.1

EC 4.1.1.50

XP_063135628.1

EC 4.1.1.50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031011.4 → NP_112273.3 S-adenosylmethionine decarboxylase proenzyme

See identical proteins and their annotated locations for NP_112273.3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

P17708

UniProtKB/TrEMBL

A6KII8

Related

ENSRNOP00000105391.1, ENSRNOT00000137078.1

Conserved Domains (1) summary

pfam01536
Location:4 → 325

SAM_decarbox; Adenosylmethionine decarboxylase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

45250289..45324939 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279557.1 → XP_063135627.1 S-adenosylmethionine decarboxylase proenzyme isoform X1

UniProtKB/Swiss-Prot

P17708

UniProtKB/TrEMBL

A6KII8
XM_063279558.1 → XP_063135628.1 S-adenosylmethionine decarboxylase proenzyme isoform X2