Hook1 hook microtubule-tethering protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hook1provided by RGD
Official Full Name: hook microtubule-tethering protein 1provided by RGD
Primary source: RGD:1309987
See related: EnsemblRapid:ENSRNOG00000026226 AllianceGenome:RGD:1309987
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytoskeletal protein binding activity; dynein light intermediate chain binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein localization to perinuclear region of cytoplasm. Predicted to act upstream of or within Golgi organization and manchette assembly. Predicted to be located in microtubule cytoskeleton. Predicted to be part of FHF complex and HOPS complex. Predicted to be active in centrosome and cytoplasm. Orthologous to human HOOK1 (hook microtubule tethering protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 221.1), Kidney (RPKM 202.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q33

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (115940199..116003482)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (110824501..110887791)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (114940053..115000691)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It has been found that the dynein effector Hook1 mediates transport of TrkB-BDNF-signaling endosomes in primary hippocampal neurons.
Title: Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytoplasmic microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton-dependent intracellular transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in endosome organization	ISO Inferred from Sequence Orthology more info
involved_in endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in lysosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within manchette assembly	ISO Inferred from Sequence Orthology more info
involved_in protein localization to perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatid development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of FHF complex	ISO Inferred from Sequence Orthology more info
part_of HOPS complex	ISO Inferred from Sequence Orthology more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein Hook homolog 1

Names: hook homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107946.1 → NP_001101416.1 protein Hook homolog 1

See identical proteins and their annotated locations for NP_001101416.1

Status: PROVISIONAL

Source sequence(s)

CH473998

UniProtKB/TrEMBL

A0A8I6AX65, A6JRI4, D3ZB48

Related

ENSRNOP00000012396.4, ENSRNOT00000012396.7

Conserved Domains (2) summary

pfam05622
Location:15 → 720

HOOK; HOOK protein

cl19219
Location:502 → 584

DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

115940199..116003482

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287638.1 → XP_063143708.1 protein Hook homolog 1 isoform X3

Related

ENSRNOP00000033736.2, ENSRNOT00000038196.3
XM_039109897.2 → XP_038965825.1 protein Hook homolog 1 isoform X1

UniProtKB/TrEMBL

A0A8I6AX65

Related

ENSRNOP00000102757.1, ENSRNOT00000162757.1

Conserved Domains (2) summary

pfam05622
Location:191 → 724

HOOK; HOOK protein

cd22225
Location:27 → 168

HkD_Hook1; Hook domain found in protein Hook 1 (Hook1) and similar proteins
XM_039109898.2 → XP_038965826.1 protein Hook homolog 1 isoform X2

UniProtKB/TrEMBL

A0A8I6AX65
XM_063287639.1 → XP_063143709.1 protein Hook homolog 1 isoform X4