Ppp4r3b protein phosphatase 4, regulatory subunit 3B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp4r3bprovided by RGD
Official Full Name: protein phosphatase 4, regulatory subunit 3Bprovided by RGD
Primary source: RGD:1309450
See related: EnsemblRapid:ENSRNOG00000003712 AllianceGenome:RGD:1309450
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Smek2; RGD1309450
Summary: Predicted to enable protein phosphatase activator activity. Predicted to be involved in DNA damage response and regulation of double-strand break repair. Predicted to act upstream of or within positive regulation of gluconeogenesis and protein dephosphorylation. Predicted to be located in several cellular components, including centrosome; chromatin; and nuclear speck. Predicted to be part of protein phosphatase 4 complex. Predicted to be active in nucleoplasm. Orthologous to human PPP4R3B (protein phosphatase 4 regulatory subunit 3B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 307.7), Spleen (RPKM 283.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q22

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (107118116..107166121)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (102917043..102965210)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (113570150..113618138)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutation in Smek2 regulating hepatic glucose metabolism causes hypersarcosinemia and hyperhomocysteinemia in rats.
Title: Mutation in Smek2 regulating hepatic glucose metabolism causes hypersarcosinemia and hyperhomocysteinemia in rats.
SMEK2 is a candidate gene for regulation of responsiveness to dietary cholesterol in rats
Title: Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in rats.

Submit: New GeneRIF Correction

General gene information

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Markers

D3S4227 (e-PCR)
- UniSTS:78535

RH141724 (e-PCR)
- UniSTS:223717

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein phosphatase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of gluconeogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of double-strand break repair	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein phosphatase 4 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase 4 complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 4 regulatory subunit 3B

Names: SMEK homolog 2, suppressor of mek1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108367.1 → NP_001101837.1 serine/threonine-protein phosphatase 4 regulatory subunit 3B

See identical proteins and their annotated locations for NP_001101837.1

Status: PROVISIONAL

Source sequence(s)

CH473996

UniProtKB/TrEMBL

A6JQA6, A6JQA8, D3ZCR4

Related

ENSRNOP00000098685.1, ENSRNOT00000166473.1

Conserved Domains (2) summary

pfam04802
Location:168 → 359

SMK-1; Component of IIS longevity pathway SMK-1

cl17171
Location:7 → 65

PH-like; Pleckstrin homology-like domain