Ghsr growth hormone secretagogue receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ghsrprovided by RGD
Official Full Name: growth hormone secretagogue receptorprovided by RGD
Primary source: RGD:621397
See related: EnsemblRapid:ENSRNOG00000024119 AllianceGenome:RGD:621397
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables growth hormone secretagogue receptor activity and peptide hormone binding activity. Involved in several processes, including cellular response to insulin-like growth factor stimulus; regulation of digestive system process; and regulation of secretion by cell. Acts upstream of or within negative regulation of insulin secretion. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic membrane. Used to study middle cerebral artery infarction. Biomarker of isolated growth hormone deficiency; multiple endocrine neoplasia; obstructive sleep apnea; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GHSR (growth hormone secretagogue receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 7.0) and Brain (RPKM 3.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (112196158..112201666)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (110268489..110271865)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (113065953..113071265)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ghrelin/GHSR Axis Induced M2 Macrophage and Alleviated Intestinal Barrier Dysfunction in a Sepsis Rat Model by Inactivating E2F1/NF-kappaB Signaling.
Title: Ghrelin/GHSR Axis Induced M2 Macrophage and Alleviated Intestinal Barrier Dysfunction in a Sepsis Rat Model by Inactivating E2F1/NF-κB Signaling.
Virus-mediated GHS-R1a expression in the basolateral amygdala blocks extinction of conditioned taste aversion memory in rats.
Title: Virus-mediated GHS-R1a expression in the basolateral amygdala blocks extinction of conditioned taste aversion memory in rats.
Energetic demands of lactation produce an increase in the expression of growth hormone secretagogue receptor in the hypothalamus and ventral tegmental area of the rat despite a reduction in circulating ghrelin.
Title: Energetic demands of lactation produce an increase in the expression of growth hormone secretagogue receptor in the hypothalamus and ventral tegmental area of the rat despite a reduction in circulating ghrelin.
Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers.
Title: Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers.
Brain and kidney GHS-R1a underexpression is associated with changes in renal function and hemodynamics during neurogenic hypertension.
Title: Brain and kidney GHS-R1a underexpression is associated with changes in renal function and hemodynamics during neurogenic hypertension.
Ghrelin receptor deletion reduces binge-like alcohol drinking in rats.
Title: Ghrelin receptor deletion reduces binge-like alcohol drinking in rats.
We found that acute and chronic caloric restriction produced similar anxiolytic and anti-despair responses in Ghsr(+/+) mice but opposite responses in Ghsr(-/-) mice.
Title: Acute But Not Chronic Calorie Restriction Defends against Stress-Related Anxiety and Despair in a GHS-R1a-Dependent Manner.
The aim of this study was to investigate the expression and the molecular and functional relationships between leptin, orexin/hypocretin and ghrelin receptors.
Title: Orexin A/Hypocretin Modulates Leptin Receptor-Mediated Signaling by Allosteric Modulations Mediated by the Ghrelin GHS-R1A Receptor in Hypothalamic Neurons.
Present findings along with previous results support the idea that ghrelin/growth hormone secretagogue receptor 1a signaling in the lateral amygdala circuit blocks conditioned taste aversion.
Title: Blocking constitutive activity of GHSR1a in the lateral amygdala facilitates acquisition of conditioned taste aversion.
GHS-R1a expression from rats with and without ligature-induced periodontitis was analyzed by real-time PCR, immunocytochemistry, and immunofluorescence.
Title: Regulation of Ghrelin Receptor by Periodontal Bacteria In Vitro and In Vivo.

Submit: New GeneRIF Correction See all GeneRIFs (79)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables growth hormone receptor binding	TAS Traceable Author Statement more info	PubMed
enables growth hormone secretagogue receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth hormone secretagogue receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables growth hormone secretagogue receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables growth hormone secretagogue receptor activity	ISO Inferred from Sequence Orthology more info
enables growth hormone secretagogue receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables growth hormone secretagogue receptor activity	TAS Traceable Author Statement more info	PubMed
enables growth hormone-releasing hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables growth hormone-releasing hormone receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables hormone binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin polymerization or depolymerization	ISO Inferred from Sequence Orthology more info
involved_in actin polymerization or depolymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in adult feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in adult feeding behavior	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin-like growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to thyroid hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in decidualization	ISO Inferred from Sequence Orthology more info
involved_in decidualization	ISS Inferred from Sequence or Structural Similarity more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in ghrelin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within growth hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in hormone-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of appetite	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macrophage apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of norepinephrine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of appetite	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of appetite	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of multicellular organism growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of small intestinal transit	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of small intestine smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gastric motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of growth hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of hindgut contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	EXP Inferred from Experiment more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of postsynapse organization	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to L-glutamate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to dexamethasone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to follicle-stimulating hormone	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to food	ISO Inferred from Sequence Orthology more info
involved_in response to growth hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	EXP Inferred from Experiment more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: growth hormone secretagogue receptor type 1

Names: GH-releasing peptide receptor; GHRP; GHS-R; ghrelin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032075.3 → NP_114464.1 growth hormone secretagogue receptor type 1

See identical proteins and their annotated locations for NP_114464.1

Status: PROVISIONAL

Source sequence(s)

AB001982

UniProtKB/Swiss-Prot

O08725

UniProtKB/TrEMBL

A6IHG7

Conserved Domains (1) summary

cd15131
Location:44 → 332

7tmA_GHSR; growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

112196158..112201666

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282642.1 → XP_063138712.1 growth hormone secretagogue receptor type 1 isoform X1

UniProtKB/Swiss-Prot

O08725

UniProtKB/TrEMBL

A6IHG7
XM_063282641.1 → XP_063138711.1 growth hormone secretagogue receptor type 1 isoform X1

UniProtKB/Swiss-Prot

O08725

UniProtKB/TrEMBL

A6IHG7

Related

ENSRNOP00000038418.1, ENSRNOT00000034960.3