Mst1 macrophage stimulating 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mst1provided by RGD
Official Full Name: macrophage stimulating 1provided by RGD
Primary source: RGD:3114
See related: EnsemblRapid:ENSRNOG00000019680 AllianceGenome:RGD:3114
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: E2F2
Summary: Enables enzyme binding activity and histone kinase activity. Involved in several processes, including cellular response to hypoxia; cellular response to type II interferon; and flagellated sperm motility. Predicted to be located in vacuole. Predicted to be active in extracellular space. Orthologous to several human genes including MST1 (macrophage stimulating 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 716.5), Adrenal (RPKM 80.4) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (117646485..117652016)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (108767886..108773425)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (116857716..116862286)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mammalian STE20-like kinase 1 inhibits synoviocytes activation in rheumatoid arthritis through mitochondrial dysfunction mediated by SIRT3/mTOR axis.
Title: Mammalian STE20-like kinase 1 inhibits synoviocytes activation in rheumatoid arthritis through mitochondrial dysfunction mediated by SIRT3/mTOR axis.
The results of this study showed that lovastatin attenuates hippocampal cell death in Pilocarpine-induced status epilepticus rat model through downregulation of the pro-apoptotic Mst1 gene.
Title: Neuroprotective effect of lovastatin through down-regulation of pro-apoptotic Mst1 gene expression in rat model pilocarpine epilepsy.
MSP and its receptor RON are involved in the smoke-induced airway inflammation in rats
Title: Roles of macrophage stimulating protein and tyrosine kinase receptor RON in smoke-induced airway inflammation of rats.
Mesenchymal stromal cells increased serum and tissue HGF levels, Met tubular expression and prevented the suppression of tubular MSP/RON expression.
Title: Mesenchymal stromal cells reset the scatter factor system and cytokine network in experimental kidney transplantation.
Interaction of Mst1 with GAPDH caused a robust phosphorylation of GAPDH and markedly increased the Mst1 activity in cardiomyocytes.
Title: Glyceraldehyde-3-phosphate dehydrogenase interacts with proapoptotic kinase mst1 to promote cardiomyocyte apoptosis.
MST1 and Fas death domain-associated protein (Daxx) mediate interferon (IFN)-gamma-induced apoptosis in microglia.
Title: Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling.
MST1-FOXO1 signaling is an important link survival factor deprivation-induced neuronal cell death
Title: Regulation of neuronal cell death by MST1-FOXO1 signaling.
A pathogenic role of the MSP/RON system in anti-Thy 1 nephritis.
Title: Neutralization of macrophage-stimulating protein ameliorates renal injury in anti-thy 1 glomerulonephritis.
Mst1 plays an important role in the induction of apoptosis of vascular smooth muscle cells, mediating the vascular remodeling process
Title: Critical role of Mst1 in vascular remodeling after injury.
E2F2, unlike E2F1, E2F3 and E2F5, does not induce apoptosis but even suppresses expression of several pro-apoptotic genes in primary cardiomyocytes; E2F1, E2F2, and E2F3 and E2F4 induce S-phase entry of primary cardiomyocytes
Title: Making omelets without breaking eggs: E2F-mediated induction of cardiomyoycte cell proliferation without stimulation of apoptosis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to type II interferon	IEP Inferred from Expression Pattern more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryo implantation	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within mammary duct terminal end bud growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mammary gland epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein modification process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cAMP-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in vacuole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hepatocyte growth factor-like protein

Names: D8h3f15s2; E2F transcription factor 2; Macrophage stimulating 1 (hepatocyte growth factor-like)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024352.1 → NP_077328.1 hepatocyte growth factor-like protein precursor

See identical proteins and their annotated locations for NP_077328.1

Status: PROVISIONAL

Source sequence(s)

X95096

UniProtKB/TrEMBL

F7FMS0, P70521, Q5EBC6

Related

ENSRNOP00000026711.5, ENSRNOT00000026711.9

Conserved Domains (4) summary

smart00020
Location:488 → 709

Tryp_SPc; Trypsin-like serine protease

smart00130
Location:377 → 459

KR; Kringle domain

cd00190
Location:489 → 712

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00024
Location:25 → 103

PAN_1; PAN domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

117646485..117652016

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080802.2 → XP_038936730.1 hepatocyte growth factor-like protein isoform X2

UniProtKB/TrEMBL

F7FMS0

Conserved Domains (2) summary

smart00130
Location:328 → 410

KR; Kringle domain

cd00190
Location:440 → 663

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_039080801.2 → XP_038936729.1 hepatocyte growth factor-like protein isoform X1

UniProtKB/TrEMBL

F7FMS0

Conserved Domains (3) summary

smart00130
Location:408 → 490

KR; Kringle domain

cd00190
Location:520 → 743

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00024
Location:32 → 111

PAN_1; PAN domain