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    Sarnp SAP domain containing ribonucleoprotein [ Mus musculus (house mouse) ]

    Gene ID: 66118, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sarnpprovided by MGI
    Official Full Name
    SAP domain containing ribonucleoproteinprovided by MGI
    Primary source
    MGI:MGI:1913368
    See related
    Ensembl:ENSMUSG00000078427 AllianceGenome:MGI:1913368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cip29; 1110005A23Rik
    Summary
    Enables chromatin binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; limb; oocyte; and retina. Orthologous to human SARNP (SAP domain containing ribonucleoprotein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 21.8), liver E14 (RPKM 16.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sarnp in Genome Data Viewer
    Location:
    10 D3; 10 77.16 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128657633..128713507)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128821764..128877638)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 19 Neighboring gene transmembrane protein 198b Neighboring gene STARR-positive B cell enhancer ABC_E1817 Neighboring gene DnaJ heat shock protein family (Hsp40) member C14 Neighboring gene STARR-positive B cell enhancer ABC_E74 Neighboring gene ORM1-like 2 (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E10662 Neighboring gene growth differentiation factor 11 Neighboring gene STARR-positive B cell enhancer ABC_E2975 Neighboring gene CD63 antigen

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A proteomic comparison of immature and mature mouse gonadotrophs reveals novel differentially expressed nuclear proteins that regulate gonadotropin gene transcription and RNA splicing. Feng J, et al. Biol Reprod, 2008 Sep. PMID 18480465, Free PMC Article
    2. Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. Dietrich JE, et al. EMBO Rep, 2015 Aug. PMID 26142281, Free PMC Article
    3. Comprehensive interactome of Otx2 in the adult mouse neural retina. Fant B, et al. Genesis, 2015 Nov. PMID 26426291
    4. Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line. Shu H, et al. Mol Cell Proteomics, 2004 Mar. PMID 14729942
    5. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1)  1 citation
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription export complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    SAP domain-containing ribonucleoprotein
    Names
    nuclear protein Hcc-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359403.1 → NP_001346332.1  SAP domain-containing ribonucleoprotein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA790241, AA881913, AC122380, AC131081, BY391953, CF949496, CJ053601, DV045727
      UniProtKB/TrEMBL
      B7ZWI2
      Conserved Domains (2) summary
      pfam02037
      Location:8 → 42
      SAP; SAP domain
      cl27333
      Location:7 → 97
      PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain

    2. NM_001359404.1 → NP_001346333.1  SAP domain-containing ribonucleoprotein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AA790241, AA881913, AC122380, AC131081, BE847644, BY391953, CF949496, CJ053601, DV045727
      Conserved Domains (1) summary
      smart00513
      Location:8 → 42
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

    3. NM_001359405.1 → NP_001346334.1  SAP domain-containing ribonucleoprotein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AA790241, AA881913, AC122380, AC131081, AI182967, BY391953, CF949496, CJ053601, DV045727
      Conserved Domains (2) summary
      pfam02037
      Location:8 → 42
      SAP; SAP domain
      cl27333
      Location:7 → 97
      PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain

    4. NM_001359406.1 → NP_001346335.1  SAP domain-containing ribonucleoprotein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AA790241, AA881913, AC122380, AC131081, BY391953, CF949496, CJ053601, DV045727, W98278
      Consensus CDS
      CCDS88117.1
      UniProtKB/TrEMBL
      A0A1W2P7G2
      Conserved Domains (1) summary
      PTZ00347
      Location:10 → 74
      PTZ00347; phosphomethylpyrimidine kinase; Provisional

    5. NM_001359407.1 → NP_001346336.1  SAP domain-containing ribonucleoprotein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AA790241, AA881913, AC122380, AC131081, BF147077, BY391953, CF949496, CJ053601, DV045727
      Consensus CDS
      CCDS88117.1
      UniProtKB/TrEMBL
      A0A1W2P7G2
      Related
      ENSMUSP00000151656.2, ENSMUST00000219512.2
      Conserved Domains (1) summary
      PTZ00347
      Location:10 → 74
      PTZ00347; phosphomethylpyrimidine kinase; Provisional

    6. NM_025364.3 → NP_079640.1  SAP domain-containing ribonucleoprotein isoform 1

      See identical proteins and their annotated locations for NP_079640.1

      Status: VALIDATED

      Source sequence(s)
      AA790241, AA881913, AC122380, AC131081, AK003453
      Consensus CDS
      CCDS36092.1
      UniProtKB/Swiss-Prot
      Q3UJZ4, Q9CU18, Q9D1J3
      UniProtKB/TrEMBL
      B2RXM7
      Related
      ENSMUSP00000100863.3, ENSMUST00000105230.4
      Conserved Domains (1) summary
      pfam02037
      Location:8 → 42
      SAP; SAP domain

    RNA

    1. NR_153109.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA790241, AA881913, AC122380, AC131081, BC094393, BY391953, CF949496
      Related
      ENSMUST00000220381.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128657633..128713507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D1J3.3 GenPept UniProtKB/Swiss-Prot:Q9D1J3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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