Gspt1 G1 to S phase transition 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gspt1provided by MGI
Official Full Name: G1 to S phase transition 1provided by MGI
Primary source: MGI:MGI:1316728
See related: Ensembl:ENSMUSG00000062203 AllianceGenome:MGI:1316728
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: G1st; Gst-1
Summary: Predicted to enable GTPase activity and translation release factor activity. Predicted to be involved in regulation of translational termination and translational termination. Predicted to act upstream of or within protein methylation. Predicted to be part of translation release factor complex. Predicted to be active in cytosolic ribosome. Orthologous to human GSPT1 (G1 to S phase transition 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 23.1), CNS E11.5 (RPKM 15.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 6.38 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (11034104..11072189, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (11216240..11254325, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Potential of GSPT1 as a novel target for glioblastoma therapy.
Title: Potential of GSPT1 as a novel target for glioblastoma therapy.
Rac1-GSPT1 represents a novel signaling axis in astrocytes that accelerates proliferation in response to inflammation, which is one important factor in the development of astrogliosis/glial scar following CNS injury
Title: A Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis Following Central Nervous System Injury.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI314175 (e-PCR)
- UniSTS:160525

RH126737 (e-PCR)
- UniSTS:209166

WI-19180 (e-PCR)
- UniSTS:79190

NoName (e-PCR)
- UniSTS:237429

NoName (e-PCR)
- UniSTS:237430

AI326449 (e-PCR)
- UniSTS:180864

AV307676 (e-PCR)
- UniSTS:180865

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables translation release factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation release factor activity	ISO Inferred from Sequence Orthology more info
enables translation release factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein methylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of translational termination	ISO Inferred from Sequence Orthology more info
involved_in regulation of translational termination	ISS Inferred from Sequence or Structural Similarity more info
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational termination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosolic ribosome	IEA Inferred from Electronic Annotation more info
is_active_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
part_of translation release factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of translation release factor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic peptide chain release factor GTP-binding subunit ERF3A

Names: G1 to S phase transition protein 1 homolog; G1 to phase transition 1; G1-to-S transition GTP binding protein; eRF3a; eukaryotic peptide chain release factor subunit 3a; eukaryotic polypeptide chain release factor 3; guanine nucleotide regulatory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130008.1 → NP_001123480.1 eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in an internal exon, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.

Source sequence(s)

AC087541, AK032059, AK148603, BB631229, CJ260597

Consensus CDS

CCDS49764.1

UniProtKB/Swiss-Prot

Q8R050

UniProtKB/TrEMBL

Q8CCV1

Related

ENSMUSP00000130583.2, ENSMUST00000167571.8

Conserved Domains (5) summary

cd01883
Location:212 → 428

EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family

COG5256
Location:208 → 632

TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]

pfam07145
Location:64 → 81

PAM2; Ataxin-2 C-terminal region

cd04089
Location:437 → 518

eRF3_II; Domain II of the eukaryotic class II release factor

cd03704
Location:524 → 630

eRF3_C_III; C-terminal domain of eRF3
NM_146066.2 → NP_666178.2 eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC087541, AK148603, BB631229, CJ260597

Consensus CDS

CCDS27961.2

UniProtKB/Swiss-Prot

E9QK49, G3UWC0, O88179, Q8K2E1, Q8R050

Related

ENSMUSP00000078940.8, ENSMUST00000080030.14

Conserved Domains (5) summary

cd01883
Location:213 → 429

EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family

COG5256
Location:209 → 633

TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]

pfam07145
Location:64 → 81

PAM2; Ataxin-2 C-terminal region

cd04089
Location:438 → 519

eRF3_II; Domain II of the eukaryotic class II release factor

cd03704
Location:525 → 631

eRF3_C_III; C-terminal domain of eRF3