Rtf2 replication termination factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rtf2provided by MGI
Official Full Name: replication termination factor 2provided by MGI
Primary source: MGI:MGI:1913654
See related: Ensembl:ENSMUSG00000027502 AllianceGenome:MGI:1913654
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rtfdc1; 1700067C04Rik; 2410001C21Rik; 5730427M17Rik
Summary: Predicted to enable DNA binding activity. Predicted to be involved in cellular response to hydroxyurea and regulation of DNA stability. Predicted to be located in replication fork. Predicted to be active in nucleus. Is expressed in embryo. Orthologous to human RTF2 (replication termination factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 28.4), placenta adult (RPKM 26.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 94.86 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (172282498..172311819)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (172440578..172469899)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124348 (e-PCR)
- UniSTS:161170

RH124955 (e-PCR)
- UniSTS:161777

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to hydroxyurea	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydroxyurea	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic DNA replication termination	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA stability	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in replication fork	ISO Inferred from Sequence Orthology more info
located_in replication fork	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: replication termination factor 2

Names: UPF0549 protein C20orf43 homolog; likely orthologue of H. sapiens chromosome 20 open reading frame 43 (C20orf43); protein RTF2 homolog; replication termination factor 2 domain containing 1; replication termination factor 2 domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.