Dtx2 deltex 2, E3 ubiquitin ligase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dtx2provided by MGI
Official Full Name: deltex 2, E3 ubiquitin ligaseprovided by MGI
Primary source: MGI:MGI:1921448
See related: Ensembl:ENSMUSG00000004947 AllianceGenome:MGI:1921448
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Deltex2; 2610524D08Rik
Summary: Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within Notch signaling pathway. Predicted to be located in nuclear membrane. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; brain; gonad; nasal cavity epithelium; and pharyngo-tympanic tube. Orthologous to human DTX2 (deltex E3 ubiquitin ligase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 19.1), thymus adult (RPKM 16.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 75.64 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (136023654..136061735)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (135994800..136032881)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deltex can act as a negative regulator of Notch signals in T cells but that endogenous levels of Deltex1 and Deltex2 are not important for regulating Notch signals during thymocyte development
Title: T cells develop normally in the absence of both Deltex1 and Deltex2.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU022494 (e-PCR)
- UniSTS:207893

Dtx2 (e-PCR), detects polymorphism
- UniSTS:465454

Dtx2 (e-PCR), detects polymorphism
- UniSTS:465455

RH124711 (e-PCR)
- UniSTS:161533

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within Notch signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: probable E3 ubiquitin-protein ligase DTX2

Names: RING-type E3 ubiquitin transferase DTX2; deltex 2 homolog; mDTX2; protein deltex-2

NP_001243025.1

EC 2.3.2.27

NP_001243026.1

EC 2.3.2.27

NP_001243027.1

EC 2.3.2.27

NP_076231.1

EC 2.3.2.27

XP_006504569.1

EC 2.3.2.27

XP_006504570.1

EC 2.3.2.27

XP_006504571.1

EC 2.3.2.27

XP_006504573.1

EC 2.3.2.27

XP_017176609.1

EC 2.3.2.27

XP_030110708.1

EC 2.3.2.27

XP_030110709.1

EC 2.3.2.27

XP_036021447.1

EC 2.3.2.27

XP_036021448.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256096.1 → NP_001243025.1 probable E3 ubiquitin-protein ligase DTX2 isoform 1

See identical proteins and their annotated locations for NP_001243025.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK012137, BB428288, CF913708

Consensus CDS

CCDS57389.1

UniProtKB/Swiss-Prot

Q8R3P2, Q9CZV3, Q9ER07, Q9ER08

Related

ENSMUSP00000106772.3, ENSMUST00000111142.9

Conserved Domains (4) summary

smart00678
Location:21 → 105

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

PHA03247
Location:204 → 392

PHA03247; large tegument protein UL36; Provisional

cd16672
Location:408 → 479

RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

pfam18102
Location:477 → 611

DTC; Deltex C-terminal domain
NM_001256097.1 → NP_001243026.1 probable E3 ubiquitin-protein ligase DTX2 isoform 3

See identical proteins and their annotated locations for NP_001243026.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an additional exon in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1. Variants 3 and 4 encode the same isoform 3.

Source sequence(s)

AK044105, BB428288, CF913708

Consensus CDS

CCDS57390.1

UniProtKB/Swiss-Prot

Q8R3P2

Related

ENSMUSP00000106774.2, ENSMUST00000111144.8

Conserved Domains (3) summary

smart00678
Location:21 → 105

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16672
Location:362 → 433

RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

pfam18102
Location:431 → 565

DTC; Deltex C-terminal domain
NM_001256098.1 → NP_001243027.1 probable E3 ubiquitin-protein ligase DTX2 isoform 3

See identical proteins and their annotated locations for NP_001243027.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1. Variants 3 and 4 encode the same isoform 3.

Source sequence(s)

AK054443, BB428288, CF913708

Consensus CDS

CCDS57390.1

UniProtKB/Swiss-Prot

Q8R3P2

Related

ENSMUSP00000106775.4, ENSMUST00000111145.10

Conserved Domains (3) summary

smart00678
Location:21 → 105

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16672
Location:362 → 433

RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

pfam18102
Location:431 → 565

DTC; Deltex C-terminal domain
NM_023742.2 → NP_076231.1 probable E3 ubiquitin-protein ligase DTX2 isoform 2

See identical proteins and their annotated locations for NP_076231.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (2) lacks an internal aa, compared to isoform 1.

Source sequence(s)

AB015423, BB443180, CF913708

Consensus CDS

CCDS39322.1

UniProtKB/TrEMBL

A0A0R4IZY1

Related

ENSMUSP00000005072.4, ENSMUST00000005072.10

Conserved Domains (3) summary

smart00678
Location:21 → 105

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd09633
Location:477 → 609

Deltex_C; Domain found at the C-terminus of deltex-like

cd00162
Location:407 → 470

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

136023654..136061735

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254848.2 → XP_030110708.1 probable E3 ubiquitin-protein ligase DTX2 isoform X1

UniProtKB/Swiss-Prot

Q8R3P2, Q9CZV3, Q9ER07, Q9ER08

Conserved Domains (4) summary

smart00678
Location:21 → 105

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

PHA03247
Location:204 → 392

PHA03247; large tegument protein UL36; Provisional

cd16672
Location:408 → 479

RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

pfam18102
Location:477 → 611

DTC; Deltex C-terminal domain
XM_036165555.1 → XP_036021448.1 probable E3 ubiquitin-protein ligase DTX2 isoform X2

Conserved Domains (3) summary

smart00678
Location:21 → 105

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16672
Location:362 → 433

RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

pfam18102
Location:431 → 565

DTC; Deltex C-terminal domain
XM_006504508.2 → XP_006504571.1 probable E3 ubiquitin-protein ligase DTX2 isoform X1

See identical proteins and their annotated locations for XP_006504571.1

UniProtKB/Swiss-Prot

Q8R3P2, Q9CZV3, Q9ER07, Q9ER08

Conserved Domains (4) summary

smart00678
Location:21 → 105

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

PHA03247
Location:204 → 392

PHA03247; large tegument protein UL36; Provisional

cd16672
Location:408 → 479

RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

pfam18102
Location:477 → 611

DTC; Deltex C-terminal domain
XM_030254849.2 → XP_030110709.1 probable E3 ubiquitin-protein ligase DTX2 isoform X2

Conserved Domains (3) summary

smart00678
Location:21 → 105

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16672
Location:362 → 433

RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

pfam18102
Location:431 → 565

DTC; Deltex C-terminal domain
XM_036165554.1 → XP_036021447.1 probable E3 ubiquitin-protein ligase DTX2 isoform X2

Conserved Domains (3) summary

smart00678
Location:21 → 105

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16672
Location:362 → 433

RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

pfam18102
Location:431 → 565

DTC; Deltex C-terminal domain
XM_006504507.3 → XP_006504570.1 probable E3 ubiquitin-protein ligase DTX2 isoform X1

See identical proteins and their annotated locations for XP_006504570.1

UniProtKB/Swiss-Prot

Q8R3P2, Q9CZV3, Q9ER07, Q9ER08

Conserved Domains (4) summary

smart00678
Location:21 → 105

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

PHA03247
Location:204 → 392

PHA03247; large tegument protein UL36; Provisional

cd16672
Location:408 → 479

RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

pfam18102
Location:477 → 611

DTC; Deltex C-terminal domain
XM_006504506.3 → XP_006504569.1 probable E3 ubiquitin-protein ligase DTX2 isoform X1

See identical proteins and their annotated locations for XP_006504569.1

UniProtKB/Swiss-Prot

Q8R3P2, Q9CZV3, Q9ER07, Q9ER08

Conserved Domains (4) summary

smart00678
Location:21 → 105

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

PHA03247
Location:204 → 392

PHA03247; large tegument protein UL36; Provisional

cd16672
Location:408 → 479

RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

pfam18102
Location:477 → 611

DTC; Deltex C-terminal domain
XM_017321120.1 → XP_017176609.1 probable E3 ubiquitin-protein ligase DTX2 isoform X2

UniProtKB/Swiss-Prot

Q8R3P2

Conserved Domains (3) summary

smart00678
Location:21 → 105

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16672
Location:362 → 433

RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

pfam18102
Location:431 → 565

DTC; Deltex C-terminal domain
XM_006504510.4 → XP_006504573.1 probable E3 ubiquitin-protein ligase DTX2 isoform X3

Conserved Domains (2) summary

cd16672
Location:114 → 185

RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

pfam18102
Location:183 → 317

DTC; Deltex C-terminal domain