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    Dbf4 DBF4 zinc finger [ Mus musculus (house mouse) ]

    Gene ID: 27214, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dbf4provided by MGI
    Official Full Name
    DBF4 zinc fingerprovided by MGI
    Primary source
    MGI:MGI:1351328
    See related
    Ensembl:ENSMUSG00000002297 AllianceGenome:MGI:1351328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ask
    Summary
    Predicted to enable protein serine/threonine kinase activator activity and protein serine/threonine kinase activity. Predicted to be involved in positive regulation of nuclear cell cycle DNA replication and regulation of cell cycle phase transition. Predicted to act upstream of or within traversing start control point of mitotic cell cycle. Located in nucleus. Is expressed in several structures, including brain ventricular layer; early conceptus; genitourinary system; and gut. Orthologous to human DBF4 (DBF4-CDC7 kinase regulatory subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 20.9), liver E14 (RPKM 16.1) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dbf4 in Genome Data Viewer
    Location:
    5 A1; 5 3.43 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (8446969..8472789, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8396969..8422725, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 22 Neighboring gene STARR-seq mESC enhancer starr_12382 Neighboring gene predicted gene, 23993 Neighboring gene STARR-seq mESC enhancer starr_12383 Neighboring gene STARR-seq mESC enhancer starr_12384 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12387 Neighboring gene solute carrier family 25, member 40 Neighboring gene STARR-positive B cell enhancer mm9_chr5:8489752-8490052 Neighboring gene STARR-seq mESC enhancer starr_12390 Neighboring gene RUN domain containing 3B Neighboring gene ATP-binding cassette, sub-family B member 1A Neighboring gene predicted gene, 31157

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of Chinese hamster homologue of yeast DBF4 (ChDBF4). Guo B, et al. Gene, 2001 Feb 21. PMID 11250080
    2. Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes. Lepke M, et al. Mol Gen Genet, 1999 Sep. PMID 10517317
    3. Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. Kneissl M, et al. J Mol Biol, 2003 Mar 14. PMID 12614612
    4. Expression of genes involved in mammalian meiosis during the transition from egg to embryo. Hwang SY, et al. Mol Reprod Dev, 2001 Jun. PMID 11389549
    5. Mettl14-mediated m(6)A modification ensures the cell-cycle progression of late-born retinal progenitor cells. Li L, et al. Cell Rep, 2023 Jun 27. PMID 37269288, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of nuclear cell cycle DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within traversing start control point of mitotic cell cycle ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Dbf4-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein DBF4 homolog A
    Names
    DBF4 homolog
    activator of S phase kinase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190717.1 → NP_001177646.1  protein DBF4 homolog A isoform 2

      See identical proteins and their annotated locations for NP_001177646.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC152165, AK132403, BB611145
      Consensus CDS
      CCDS57324.1
      UniProtKB/Swiss-Prot
      Q9QZ41
      Related
      ENSMUSP00000002368.10, ENSMUST00000002368.16
      Conserved Domains (2) summary
      cd00027
      Location:48 → 92
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cl02684
      Location:287 → 334
      zf-DBF; DBF zinc finger

    2. NM_013726.3 → NP_038754.1  protein DBF4 homolog A isoform 1

      See identical proteins and their annotated locations for NP_038754.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC152165, AK132403, BB611145, BC138709
      Consensus CDS
      CCDS19081.1
      UniProtKB/Swiss-Prot
      B7ZNS0, Q3TQP4, Q3V1K2, Q6NSQ1, Q9CXF2, Q9QZ41
      UniProtKB/TrEMBL
      B2RS44
      Related
      ENSMUSP00000132906.2, ENSMUST00000171808.8
      Conserved Domains (2) summary
      cd00027
      Location:48 → 92
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cl02684
      Location:288 → 335
      zf-DBF; DBF zinc finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      8446969..8472789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003955657.2 RNA Sequence

    2. XR_003955658.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZ41.1 GenPept UniProtKB/Swiss-Prot:Q9QZ41

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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