Mfn2 mitofusin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mfn2provided by RGD
Full Name: mitofusin 2provided by RGD
Primary source: RGD:628843
See related: EnsemblRapid:ENSRNOG00000046424 AllianceGenome:RGD:628843
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: HSG
Summary: Enables several functions, including GTP binding activity; identical protein binding activity; and small GTPase binding activity. Involved in several processes, including negative regulation of organelle organization; positive regulation of steroid hormone secretion; and regulation of reactive oxygen species biosynthetic process. Located in cytosol and mitochondrial outer membrane. Used to study carotid stenosis. Biomarker of several diseases, including artery disease (multiple); obesity; prediabetes syndrome; steatotic liver disease (multiple); and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; Charcot-Marie-Tooth disease type 6; and multiple symmetric lipomatosis. Orthologous to human MFN2 (mitofusin 2). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Note: GeneIDs: 64476 and 100911485 are annotated independently on Rnor_6.0 but may be redundant loci. [09 Feb 2015]
Expression: Biased expression in Heart (RPKM 743.7), Muscle (RPKM 606.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (163587463..163617363, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (158304285..158335502, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (164684244..164715414, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MFN2-dependent mitochondrial dysfunction contributes to Relm-beta-induced pulmonary arterial hypertension via USP18/Twist1/miR-214 pathway.
Title: MFN2-dependent mitochondrial dysfunction contributes to Relm-β-induced pulmonary arterial hypertension via USP18/Twist1/miR-214 pathway.
Increased Ca2 + transport across the mitochondria-associated membranes by Mfn2 inhibiting endoplasmic reticulum stress in ischemia/reperfusion kidney injury.
Title: Increased Ca2 + transport across the mitochondria-associated membranes by Mfn2 inhibiting endoplasmic reticulum stress in ischemia/reperfusion kidney injury.
Moderate mechanical strain and exercise reduce inflammation and excessive autophagy in osteoarthritis by downregulating mitofusin 2.
Title: Moderate mechanical strain and exercise reduce inflammation and excessive autophagy in osteoarthritis by downregulating mitofusin 2.
DNA Methylation-Mediated Mfn2 Gene Regulation in the Brain: A Role in Brain Trauma-Induced Mitochondrial Dysfunction and Memory Deficits.
Title: DNA Methylation-Mediated Mfn2 Gene Regulation in the Brain: A Role in Brain Trauma-Induced Mitochondrial Dysfunction and Memory Deficits.
MFN2 deficiency promotes cardiac response to hypobaric hypoxia by reprogramming cardiomyocyte metabolism.
Title: MFN2 deficiency promotes cardiac response to hypobaric hypoxia by reprogramming cardiomyocyte metabolism.
Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function.
Title: Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function.
Mitofusin 2 Sustains the Axonal Mitochondrial Network to Support Presynaptic Ca[2+] Homeostasis and the Synaptic Vesicle Cycle in Rat Hippocampal Axons.
Title: Mitofusin 2 Sustains the Axonal Mitochondrial Network to Support Presynaptic Ca(2+) Homeostasis and the Synaptic Vesicle Cycle in Rat Hippocampal Axons.
Mitofusin 1 and 2 differentially regulate mitochondrial function underlying Ca[2+] signaling and proliferation in rat aortic smooth muscle cells.
Title: Mitofusin 1 and 2 differentially regulate mitochondrial function underlying Ca(2+) signaling and proliferation in rat aortic smooth muscle cells.
Mitofusin 2 Integrates Mitochondrial Network Remodelling, Mitophagy and Renewal of Respiratory Chain Proteins in Neurons after Oxygen and Glucose Deprivation.
Title: Mitofusin 2 Integrates Mitochondrial Network Remodelling, Mitophagy and Renewal of Respiratory Chain Proteins in Neurons after Oxygen and Glucose Deprivation.
Treatment of Pelvic Organ Prolapse by the Downregulation of the Expression of Mitofusin 2 in Uterosacral Ligament Tissue via Mesenchymal Stem Cells.
Title: Treatment of Pelvic Organ Prolapse by the Downregulation of the Expression of Mitofusin 2 in Uterosacral Ligament Tissue via Mesenchymal Stem Cells.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
enables proteoglycan binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	IEA Inferred from Electronic Annotation more info
involved_in aerobic respiration	ISO Inferred from Sequence Orthology more info
involved_in aerobic respiration	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in blastocyst formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blastocyst formation	ISO Inferred from Sequence Orthology more info
involved_in camera-type eye morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within camera-type eye morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to L-glutamate	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to ionizing radiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to low-density lipoprotein particle stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to manganese ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to mercaptoethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to testosterone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular distribution of mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mitochondrial calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fusion	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrial fusion	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fusion	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial membrane organization	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial membrane organization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial membrane organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion localization	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion localization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of reactive oxygen species biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of release of cytochrome c from mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of estradiol secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hydrogen peroxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of progesterone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of reactive oxygen species biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to phagophore assembly site	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to phagophore assembly site	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to D-galactose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to L-arginine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to flavonoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypobaric hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to unfolded protein	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in type 2 mitophagy	IEA Inferred from Electronic Annotation more info
involved_in type 2 mitophagy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitofusin-2

Names: hypertension-related protein; mitochondrial transmembrane GTPase FZO1A; mitofusin-2-like; transmembrane GTPase MFN2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429964.1 → NP_001416893.1 mitofusin-2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

O09013, Q8R500

UniProtKB/TrEMBL

D4A9N3, Q6IRL2
NM_001429965.1 → NP_001416894.1 mitofusin-2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

O09013, Q8R500

UniProtKB/TrEMBL

D4A9N3, Q6IRL2
NM_001429966.1 → NP_001416895.1 mitofusin-2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

O09013, Q8R500

UniProtKB/TrEMBL

D4A9N3, Q6IRL2
NM_001429967.1 → NP_001416896.1 mitofusin-2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

O09013, Q8R500

UniProtKB/TrEMBL

D4A9N3, Q6IRL2
NM_001429968.1 → NP_001416897.1 mitofusin-2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

O09013, Q8R500

UniProtKB/TrEMBL

D4A9N3, Q6IRL2
NM_001429969.1 → NP_001416898.1 mitofusin-2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

O09013, Q8R500

UniProtKB/TrEMBL

D4A9N3, Q6IRL2
NM_001429970.1 → NP_001416899.1 mitofusin-2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

O09013, Q8R500

UniProtKB/TrEMBL

D4A9N3, Q6IRL2
NM_130894.5 → NP_570964.4 mitofusin-2

See identical proteins and their annotated locations for NP_570964.4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

O09013, Q8R500

UniProtKB/TrEMBL

D4A9N3, Q6IRL2

Conserved Domains (2) summary

cd09912
Location:97 → 349

DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins

pfam04799
Location:595 → 754

Fzo_mitofusin; fzo-like conserved region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

163587463..163617363 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008764288.4 → XP_008762510.1 mitofusin-2 isoform X1

Related

ENSRNOP00000052539.3, ENSRNOT00000055680.5

Conserved Domains (2) summary

cd09912
Location:97 → 349

DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins

pfam04799
Location:595 → 754

Fzo_mitofusin; fzo-like conserved region
XM_063288356.1 → XP_063144426.1 mitofusin-2 isoform X1